Recombinant Mouse BECN1 Protein (1-448 aa), His-SUMO-tagged

• Cat.No.: BECN1-2059M
• Product Overview: Recombinant Mouse BECN1 Protein (1-448 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Epigenetics and Nuclear Signaling. Protein Description: Full Length.

Specification

• Description: Plays a central role in autophagy (PubMed:10604474, PubMed:12372286, PubMed:19270693). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis (PubMed:19270693, PubMed:25275521). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex forms (PubMed:25275521). Involved in endocytosis including endosome formation in neuronal cells (PubMed:25275521). May play a role in antiviral host defense (By similarity).
• Source: E. coli
• Species: Mouse
• Tag: His-SUMO
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 67.6 kDa
• Protein length: 1-448 aa
• AA Sequence: MEGSKASSSTMQVSFVCQRCSQPLK LDTSFKILDRVTIQELTAPLLTTAQ AKPGETQEEEANSGEEPFIETRQDG VSRRFIPPARMMSTESANSFTLIGE ASDGGTMENLSRRLKVTGDLFDIMS GQTDVDHPLCEECTDTLLDQLDTQL NVTENECQNYKRCLEILEQMNEDDS EQLQRELKELALEEERLIQELEDVE KNRKVVAENLEKVQAEAERLDQEEA QYQREYSEFKRQQLELDDELKSVEN QVRYAQIQLDKLKKTNVFNATFHIW HSGQFGTINNFRLGRLPSVPVEWNE INAAWGQTVLLLHALANKMGLKFQR YRLVPYGNHSYLESLTDKSKELPLY CSGGLRFFWDNKFDHAMVAFLDCVQ QFKEEVEKGETRFCLPYRMDVEKGK IEDTGGSGGSYSIKTQFNSEEQWTK ALKFMLTNLKWGLAWVSSQFYNK
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Becn1 beclin 1, autophagy related [ Mus musculus ]
• Official Symbol: BECN1
• Synonyms: BECN1; Atg6; MGC6843; 4921513J16Rik; 5430417M23Rik
• Gene ID: 56208
• mRNA Refseq: NM_019584
• Protein Refseq: NP_062530
• UniProt ID: O88597

Reviews

09/15/2022

Top-notch analysis, enhances research outcomes.

02/11/2022

Reliable data source, trusted for data accuracy.

04/08/2018

Expertise shines, a critical research resource.

Q&As

What role does BECN1 play in cancer biology?

BECN1 is involved in cancer, influencing both tumor suppression and survival.

How does BECN1 contribute to cellular homeostasis?

It helps maintain cellular health by regulating the degradation and recycling of cellular components.

What is the primary role of BECN1 in autophagy?

BECN1, a key autophagy protein, initiates the autophagic process, crucial for cellular waste disposal.

How does BECN1 interact with other autophagy-related proteins?

BECN1 interacts with a network of autophagy proteins, coordinating the autophagic response.

What is the impact of altered BECN1 activity on neurodegenerative diseases?

Altered BECN1 activity is linked to neurodegeneration, as autophagy is essential for neuronal health.

What potential therapeutic applications arise from targeting BECN1 in disease treatment?

Targeting BECN1 could provide new treatments for cancer and neurodegenerative diseases by modulating autophagy.

How do genetic variations in BECN1 affect autophagy?

Genetic mutations in BECN1 can lead to dysfunctional autophagy, affecting cell survival and health.