Recombinant Human BECN1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: BECN1-3340H
• Product Overview: BECN1 MS Standard C13 and N15-labeled recombinant protein (NP_003757) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 51.7 kDa
• AA Sequence: MEGSKTSNNSTMQVSFVCQRCSQPL KLDTSFKILDRVTIQELTAPLLTTA QAKPGETQEEETNSGEEPFIETPRQ DGVSRRFIPPARMMSTESANSFTLI GEASDGGTMENLSRRLKVTGDLFDI MSGQTDVDHPLCEECTDTLLDQLDT QLNVTENECQNYKRCLEILEQMNED DSEQLQMELKELALEEERLIQELED VEKNRKIVAENLEKVQAEAERLDQE EAQYQREYSEFKRQQLELDDELKSV ENQMRYAQTQLDKLKKTNVFNATFH IWHSGQFGTINNFRLGRLPSVPVEW NEINAAWGQTVLLLHALANKMGLKF QRYRLVPYGNHSYLESLTDKSKELP LYCSGGLRFFWDNKFDHAMVAFLDC VQQFKEEVEKGETRFCLPYRMDVEK GKIEDTGGSGGSYSIKTQFNSEEQW TKALKFMLTNLKWGLAWVSSQFYNK TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: BECN1 beclin 1 [ Homo sapiens (human) ]
• Official Symbol: BECN1
• Synonyms: BECN1; beclin 1, autophagy related; beclin 1 (coiled coil, moesin like BCL2 interacting protein); beclin-1; ATG6; ATG6 autophagy related 6 homolog (S. cerevisiae); VPS30; ATG6 autophagy related 6 homolog; coiled-coil myosin-like BCL2-interacting protein; beclin 1 (coiled-coil, moesin-like BCL2 interacting protein); beclin 1 (coiled-coil, moesin-like BCL2-interacting protein); beclin1
• Gene ID: 8678
• mRNA Refseq: NM_003766
• Protein Refseq: NP_003757
• MIM: 604378
• UniProt ID: Q14457