BIRC7
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Official Full Name
baculoviral IAP repeat containing 7
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Background
PUMA (p53 up-regulated modulator of apoptosis) is one of the pro-apoptotic Bcl-2 family members that are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-alpha and PUMA-beta. PUMA proteins bind Bcl- -
Synonyms
BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 5;
- Involved Pathway
- Protein Function
- Interacting Protein
- BIRC7 Related Articles
- BIRC7 Related Research Area
BIRC7 involved in several pathways and played different roles in them. We selected most pathways BIRC7 participated on our site, such as Ubiquitin mediated proteolysis, Apoptosis, Toxoplasmosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with BIRC7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Ubiquitin mediated proteolysis | CDC23;SIAH1;UBE4A;UBE3B;HUWE1;UBE2S;UBOX5;NHLRC1;TRIM37 |
| Apoptosis | MAP3K14;CSF2RB;BIRC8;PRKACBA;DSG1;BCL2L11;CAPN2B;IRF2A;BOK |
| Toxoplasmosis | TGFB1;HSPA1B;PPIF;IL12B;SOCS1;MAP3K7;BIRC3;IKBKG;NFKB1 |
| Pathways in cancer | GNB4;Ar;NKX3-1;GNB1;PTGER1;PML;FZD10;IKBKG;VEGFB |
| Small cell lung cancer | LAMA1;MAX;PTGS2;IKBKG;RXRA;BCL2;LAMA2;PIK3R1;TP53 |
BIRC7 has several biochemical functions, for example, cysteine-type endopeptidase inhibitor activity, cysteine-type endopeptidase inhibitor activity involved in apoptotic process, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by BIRC7 itself. We selected most functions BIRC7 had, and list some proteins which have the same functions with BIRC7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cysteine-type endopeptidase inhibitor activity | CST2;CST8;CST4;AHSG1;SERPINB13;AHSG2;AHSG;CST6;SERPINB3 |
| cysteine-type endopeptidase inhibitor activity involved in apoptotic process | NAIP1;SNCA;VIL1;RPS6KA1;MT3;NOL3;TFAP2B;XIAP;IGF1RA |
| enzyme binding | ATF7;UGT1A4;ATXN10;MAP2K7;SCNM1;HAND2;AXIN2;PHB;NOTCH3 |
| ligase activity | ZSWIM2;CBX4;PCXA;RNF5;PIAS4;RNF133;ADSSL;RNF139;MARCH5 |
| protein binding | RNF135;TUBA1B;RRM2B;EN1;ATP6AP2;MED19;IRF4;SOST;KIAA0146 |
| ubiquitin-protein transferase activity | MKRN1;RAG1;FBXO30A;TRIM5;RNF187;TRAF4B;ANAPC4;UBE2O;FBXO7 |
| zinc ion binding | DPP3;TRIM7;CNOT4B;FHL3B;OTUD7B;RNF26;TRIM42;TRAF2;BTR22 |
BIRC7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with BIRC7 here. Most of them are supplied by our site. Hope this information will be useful for your research of BIRC7.
CASP9; DIABLO; POLR1C; PHF1
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