Recombinant Full Length Human BIRC7 Protein, GST-tagged

Cat.No. : BIRC7-1640HF
Product Overview : Human BIRC7 full-length ORF ( NP_647478.1, 1 a.a. - 298 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : The protein encoded by this gene is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Two transcript variants encoding different isoforms have been found for this gene. The two isoforms have different antiapoptotic properties, with isoform alpha protecting cells from apoptosis induced by staurosporine and isoform b protecting cells from apoptosis induced by etoposide.
Source : In Vitro Cell Free System
Species : Human
Tag : GST
Form : 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Molecular Mass : 59.2 kDa
Protein Length : 298 amino acids
AA Sequence : MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCl, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens ]
Official Symbol : BIRC7
Synonyms : BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 50; LIVIN; MLIAP; ML-IAP
Gene ID : 79444
mRNA Refseq : NM_022161
Protein Refseq : NP_071444
MIM : 605737
UniProt ID : Q96CA5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How can BIRC7 be used to treat cancer? 09/22/2022

In response to the role of BIRC7 in cancer, some therapeutics can be developed, such as inhibitors or antibodies targeting BIRC7, which are used to inhibit the proliferation and survival of tumor cells and enhance the attack ability of the immune system.

How does BIRC7 correlate with other genes? 09/07/2022

It has complex associations with other genes and may interact with multiple genes to participate in biochemical processes such as apoptosis.

What are the mutation types in BIRC7? 06/22/2022

The types of mutations in BIRC7 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

What is the role of BIRC7 in cancer? 09/04/2021

BIRC7 has a dual role in cancer, on the one hand, it can promote the proliferation and survival of tumor cells, and on the other hand, it can also suppress the immune response and help tumor cells evade the attack of the immune system.

How to study the regulatory mechanism of BIRC7? 12/07/2020

Studying the regulatory mechanism of BIRC7 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Can the expression pattern of BIRC7 be used for disease diagnosis? 09/26/2020

By detecting the expression pattern of BIRC7, it can assist in the diagnosis of certain diseases, such as cancer, neurodegenerative diseases, etc.

Customer Reviews (3)

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10/27/2022

    High solubility, fast dissolution, good adaptability to solvents.

    01/09/2022

      BIRC7 has performed well in various experiments and is a reliable choice.

      12/22/2021

        Very suitable for biological activity experiment, good activity.

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