Recombinant Human Baculoviral IAP Repeat-containing 7, His-tagged

• Cat.No.: BIRC7-375H
• Product Overview: Recombinant human Livin fused to His-tag at N-terminus was expressed in E.coli and purified by conventional chromatography techniques, 34 kDa (318 aa).

Specification

• Cat. No.: BIRC7-375H
• Description: Livin is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING zinc finger (RZF) domain. Livin has direct interaction with several caspases including caspase-3, -7, and –9. This protein inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 100 mM NaCl, 2 mM EDTA, 20% glycerol
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: BIRC7 baculoviral IAP repeat-containing 7 [ Homo sapiens ]
• Synonyms: BIRC7; baculoviral IAP repeat-containing 7; KIAP; LIVIN; MLIAP; RNF50; ML-IAP; livin inhibitor of apoptosis; OTTHUMP00000031536; OTTHUMP00000031537; livin inhibitor-of-apoptosis; kidney inhibitor of apoptosis protein; melanoma inhibitor of apoptosis protein; baculoviral IAP repeat-containing protein 7; mliap, RNF50; livin; RING finger protein 50
• Gene ID: 79444
• mRNA Refseq: NM_022161
• Protein Refseq: NP_071444
• MIM: 605737
• UniProt ID: Q96CA5
• Chromosome Location: 20q13.3
• Function: enzyme binding; metal ion binding; zinc ion binding

Reviews

10/27/2022

High solubility, fast dissolution, good adaptability to solvents.

01/09/2022

BIRC7 has performed well in various experiments and is a reliable choice.

12/22/2021

Very suitable for biological activity experiment, good activity.

Q&As

How can BIRC7 be used to treat cancer?

In response to the role of BIRC7 in cancer, some therapeutics can be developed, such as inhibitors or antibodies targeting BIRC7, which are used to inhibit the proliferation and survival of tumor cells and enhance the attack ability of the immune system.

How does BIRC7 correlate with other genes?

It has complex associations with other genes and may interact with multiple genes to participate in biochemical processes such as apoptosis.

What are the mutation types in BIRC7?

The types of mutations in BIRC7 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

What is the role of BIRC7 in cancer?

BIRC7 has a dual role in cancer, on the one hand, it can promote the proliferation and survival of tumor cells, and on the other hand, it can also suppress the immune response and help tumor cells evade the attack of the immune system.

How to study the regulatory mechanism of BIRC7?

Studying the regulatory mechanism of BIRC7 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Can the expression pattern of BIRC7 be used for disease diagnosis?

By detecting the expression pattern of BIRC7, it can assist in the diagnosis of certain diseases, such as cancer, neurodegenerative diseases, etc.