Recombinant Human Baculoviral IAP Repeat-containing 7, His-tagged

• Cat.No.: BIRC7-375H
• Product Overview: Recombinant human Livin fused to His-tag at N-terminus was expressed in E.coli and purified by conventional chromatography techniques, 34 kDa (318 aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Livin is a member of the family of inhibitor of apoptosis proteins (IAP) and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING zinc finger (RZF) domain. Livin has direct interaction with several caspases including caspase-3, -7, and –9. This protein inhibits the activation of caspase-9 induced by Apaf-1, cytochrome c, and dATP.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGPKDSAKCL HRGPQPSHWA AGDGPTQERC GPRSLGSPVL GLDTCRAWDH VDGQILGQLR PLTEEEEEEG AGATLSRGPA FPGMGSEELR LASFYDWPLT AEVPPELLAA AGFFHTGHQD KVRCFFCYGG LQSWKRGDDP WTEHAKWFPS CQFLLRSKGR DFVHSVQETH SQLLGSWDPW EEPEDAAPVA PSVPASGYPE LPTPRREVQS ESAQEPGGVS PAEAQRAWWV LEPPGARDVE AQLRRLQEER TCKVCLDRAV SIVFVPCGHL VCAECAPGLQ LCPICRAPVR SRVRTFLS
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 1 mM DTT, 100 mM NaCl, 2 mM EDTA, 20% glycerol
• Purity: > 90% by SDS - PAGE
• Concentration: 1 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: BIRC7 baculoviral IAP repeat-containing 7 [ Homo sapiens ]
• Synonyms: BIRC7; baculoviral IAP repeat-containing 7; KIAP; LIVIN; MLIAP; RNF50; ML-IAP; livin inhibitor of apoptosis; OTTHUMP00000031536; OTTHUMP00000031537; livin inhibitor-of-apoptosis; kidney inhibitor of apoptosis protein; melanoma inhibitor of apoptosis protein; baculoviral IAP repeat-containing protein 7; mliap, RNF50; livin; RING finger protein 50
• Gene ID: 79444
• mRNA Refseq: NM_022161
• Protein Refseq: NP_071444
• MIM: 605737
• UniProt ID: Q96CA5
• Chromosome Location: 20q13.3
• Function: enzyme binding; metal ion binding; zinc ion binding