Recombinant Human BIRC7 Protein (M1-S298), His tagged
| Cat.No. : | BIRC7-0093H |
| Product Overview : | Recombinant Human 6His-TEV-(GG)-LIVIN(BIRC7) (M1-S298 end) Protein was expressed in E. coli. |
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- Gene Information
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| Description : | Apoptotic regulator capable of exerting proapoptotic and anti-apoptotic activities and plays crucial roles in apoptosis, cell proliferation, and cell cycle control. Its anti-apoptotic activity is mediated through the inhibition of CASP3, CASP7 and CASP9, as well as by its E3 ubiquitin-protein ligase activity. As it is a weak caspase inhibitor, its anti-apoptotic activity is thought to be due to its ability to ubiquitinate DIABLO/SMAC targeting it for degradation thereby promoting cell survival. May contribute to caspase inhibition, by blocking the ability of DIABLO/SMAC to disrupt XIAP/BIRC4-caspase interactions. Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and MAP3K7/TAK1. In vitro, inhibits CASP3 and proteolytic activation of pro-CASP9. |
| Source : | E. coli |
| Species : | Human |
| Tag : | His |
| Form : | Liquid |
| Protein Length : | M1-S298 |
| Endotoxin : | < 0.01 EU per μg of the protein |
| Purity : | 90% |
| Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
| Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
| Storage Buffer : | Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol |
| Shipping : | It is shipped out with blue ice. |
| Gene Name : | BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens (human) ] |
| Official Symbol : | BIRC7 |
| Synonyms : | BIRC7; baculoviral IAP repeat containing 7; baculoviral IAP repeat-containing protein 7; KIAP; kidney inhibitor of apoptosis protein; livin; livin inhibitor of apoptosis; melanoma inhibitor of apoptosis protein; ML IAP; mliap; RNF50; RING finger protein 50; LIVIN; MLIAP; ML-IAP; |
| Gene ID : | 79444 |
| mRNA Refseq : | NM_022161 |
| Protein Refseq : | NP_071444 |
| MIM : | 605737 |
| UniProt ID : | Q96CA5 |
Products Types
| ◆ Recombinant Protein | ||
| Birc7-1870M | Recombinant Mouse Birc7 Protein, Myc/DDK-tagged | +Inquiry |
| BIRC7-449H | Recombinant Human BIRC7 Protein, His (Fc)-Avi-tagged | +Inquiry |
| BIRC7-1036M | Recombinant Mouse BIRC7 Protein, His (Fc)-Avi-tagged | +Inquiry |
| BIRC7-0092H | Recombinant Human BIRC7 Protein (M1-S298), Tag Free | +Inquiry |
| BIRC7-231H | Recombinant Human BIRC7 Protein, GST-tagged | +Inquiry |
| ◆ Lysates | ||
| BIRC7-8447HCL | Recombinant Human BIRC7 293 Cell Lysate | +Inquiry |
| BIRC7-8448HCL | Recombinant Human BIRC7 293 Cell Lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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