Recombinant Full Length Human BIRC7 Protein, C-Flag-tagged

Cat.No. : BIRC7-2176HFL
Product Overview : Recombinant Full Length Human BIRC7 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.
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Description : This gene encodes a member of the inhibitor of apoptosis protein (IAP) family, and contains a single copy of a baculovirus IAP repeat (BIR) as well as a RING-type zinc finger domain. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. Elevated levels of the encoded protein may be associated with cancer progression and play a role in chemotherapy sensitivity. Alternative splicing results in multiple transcript variants.
Source : Mammalian cells
Species : Human
Tag : Flag
Form : 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Molecular Mass : 32.6 kDa
AA Sequence : MGPKDSAKCLHRGPQPSHWAAGDGP TQERCGPRSLGSPVLGLDTCRAWDH VDGQILGQLRPLTEEEEEEG AGATLSRGPAFPGMGSEELRLASFY DWPLTAEVPPELLAAAGFFHTGHQD KVRCFFCYGGLQSWKRGDDP WTEHAKWFPSCQFLLRSKGRDFVHS VQETHSQLLGSWDPWEEPEDAAPVA PSVPASGYPELPTPRREVQS ESAQEPGGVSPAQAQRAWWVLEPPG ARDVEAQLRRLQEERTCKVCLDRAV SIVFVPCGHLVCAECAPGLQ LCPICRAPVRSRVRTFLS TRTRPLEQKLISEEDLAANDILDYK DDDDKV
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining.
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade.
Concentration : >50 ug/mL as determined by microplate BCA method.
Preparation : Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
Protein Families : Druggable Genome
SDS-PAGE: Coomassie blue staining of purified BIRC7 protein.
Gene Name : BIRC7 baculoviral IAP repeat containing 7 [ Homo sapiens (human) ]
Official Symbol : BIRC7
Synonyms : KIAP; LIVIN; MLIAP; RNF50; ML-IAP
Gene ID : 79444
mRNA Refseq : NM_139317.3
Protein Refseq : NP_647478.1
MIM : 605737
UniProt ID : Q96CA5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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How can BIRC7 be used to treat cancer? 09/22/2022

In response to the role of BIRC7 in cancer, some therapeutics can be developed, such as inhibitors or antibodies targeting BIRC7, which are used to inhibit the proliferation and survival of tumor cells and enhance the attack ability of the immune system.

How does BIRC7 correlate with other genes? 09/07/2022

It has complex associations with other genes and may interact with multiple genes to participate in biochemical processes such as apoptosis.

What are the mutation types in BIRC7? 06/22/2022

The types of mutations in BIRC7 include point mutations, insertions/deletions, duplications, etc., which may cause structural and functional abnormalities of the protein.

What is the role of BIRC7 in cancer? 09/04/2021

BIRC7 has a dual role in cancer, on the one hand, it can promote the proliferation and survival of tumor cells, and on the other hand, it can also suppress the immune response and help tumor cells evade the attack of the immune system.

How to study the regulatory mechanism of BIRC7? 12/07/2020

Studying the regulatory mechanism of BIRC7 requires a comprehensive use of various experimental methods and techniques, such as gene knockout, transcriptome analysis, and protein-protein interactions.

Can the expression pattern of BIRC7 be used for disease diagnosis? 09/26/2020

By detecting the expression pattern of BIRC7, it can assist in the diagnosis of certain diseases, such as cancer, neurodegenerative diseases, etc.

Customer Reviews (3)

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10/27/2022

    High solubility, fast dissolution, good adaptability to solvents.

    01/09/2022

      BIRC7 has performed well in various experiments and is a reliable choice.

      12/22/2021

        Very suitable for biological activity experiment, good activity.

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