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Official Full Name B lymphoid tyrosine kinase
Background This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.
Synonyms BLK; B lymphoid tyrosine kinase; tyrosine-protein kinase Blk; MGC10442; p55-Blk; b lymphocyte kinase; BLK nonreceptor tyrosine kinase; MODY11
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Hi-5 Inscet Cell
    • Hi-5 Insect Cell
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human BLK-10238H Recombinant Human BLK, GST-tagged E.coli GST
    Human BLK-1345H Recombinant Human B Lymphoid Tyrosine Kinase, His-tagged Hi-5 Insect Cell His
    Human BLK-1366H Recombinant Human BLK (Active), GST-tagged Sf9 Insect Cell GST
    Human BLK-238H Recombinant Human BLK Protein, GST-His-tagged Sf9 Insect Cell GST/His
    Human BLK-239H Recombinant Human BLK Protein, GST-His-tagged Wheat Germ GST
    Human BLK-240H Recombinant Human BLK Protein, GST-His-tagged Wheat Germ GST
    Human BLK-250H Recombinant Human B lymphoid Tyrosine Kinase, GST-tagged, Active Sf9 Insect Cell GST
    Human BLK-26112TH Recombinant Human BLK, His-tagged Hi-5 Inscet Cell His
    Human BLK-461H Recombinant Human BLK, GST-tagged Sf9 Insect Cell GST
    Human BLK-5368H Recombinant Human B Lymphoid Tyrosine Kinase, His-tagged Insect Cell His
    Human BLK-614HCL Recombinant Human BLK cell lysate Insect Cell N/A
    Human BLK-642H Recombinant Human B Lymphoid Tyrosine Kinase E.coli N/A
    Human BLK-770H Recombinant Human BLK Protein, His-tagged E.coli His
    Human BLK-953H Recombinant Human BLK, GST tagged Insect Cell GST
    Mouse BLK-2414M Recombinant Mouse BLK Protein Mammalian Cell His
    Zebrafish BLK-3316Z Recombinant Zebrafish BLK Mammalian Cell His
    Kit-1565 BLK Kinase Binding Assay Kit N/A
    Kit-1566 BLK Activity Assay Kit N/A

    blk involved in several pathways and played different roles in them. We selected most pathways blk participated on our site, such as Adaptive Immune System, Alpha-synuclein signaling, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, which may be useful for your reference. Also, other proteins which involved in the same pathway with blk were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System AP1G1; SPSB4; ASB4; UBE2J2; LILRA2; MGC174155; CD96; NPEPPS; DCTN2; ASB2
    Alpha-synuclein signaling BLK; STUB1; PARK7; FKBP1A; TOR1A; CSNK2A1; KLK6
    Antigen activates B Cell Receptor (BCR) leading to generation of second messengers IGKC; ITPR2; AKR1C1; STIM1B; IGLC2; IGKV1-5; BLK; PIK3AP1; IGHM; AHCYL1
    Apoptosis Modulation and Signaling PTRH2; PTPN13; CDKN2A; CAPNS1; SEPT4; BLK; DIABLO; CRADD; DAXX; DFFA
    B Cell Receptor Signaling Pathway GSK3AB; CD81; ARPC2; CDK6; cgr2b; LILRB3; LAT2; NFATC2; DUSP4; CD79B
    CXCR4-mediated signaling events CSK; PAG1; ADRBK1; MAPKAP1; JAK2; GNA13; CFL1; CRK; GNB2L1; ARR3
    Class I PI3K signaling events BLK; ITK; PLEKHA1; ADAP1; ARF1
    EPHA forward signaling BLK; EPHA2; EFNA3; EFNA1; EFNA2; ARHGEF15; CRKL; EFNA5

    blk has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by blk itself. We selected most functions blk had, and list some proteins which have the same functions with blk. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding AACS; GRK7; ASCC3; SLC22A5; KHK; CCT6A; SMC1B; MAP3K3; AXL; PRKACB
    non-membrane spanning protein tyrosine kinase activity FES; JAK2A; JAK1; BLK; PTK6B; JAK2; ABL1; SYK; FYNA; PRKCD
    protein binding NOS3; CDKN3; EXOC7; LATS1; LHX9; EIF4H; SLC39A7; SEPT7; IRS2; POP1
    protein tyrosine kinase activity PTK6B; FYNB; TESK2; IGF1R; JAK2; INSR; DYRK1A; DYRK4; ZNF143B; PTK2B
    receptor binding FGF6A; CROT; HLA-A; ABCA1; IFNL3; HLA-E; INSL4; FLT3LG; LRRC4B; CSK

    blk has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with blk here. Most of them are supplied by our site. Hope this information will be useful for your research of blk.

    EGFR; 80125; STAT3; EFS; saicar; ERBB2; MET; AR; KIT

    Carmona, FD; Martin, J; et al. Genetics of vasculitis. CURRENT OPINION IN RHEUMATOLOGY 27:10-17(2015).
    Sugiura, T; Kawaguchi, Y; et al. Association between a C8orf13-BLK Polymorphism and Polymyositis/Dermatomyositis in the Japanese Population: An Additive Effect with STAT4 on Disease Susceptibility. PLOS ONE 9:-(2014).

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