|Official Full Name||B lymphoid tyrosine kinase|
|Background||This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors.|
|Synonyms||BLK; B lymphoid tyrosine kinase; tyrosine-protein kinase Blk; MGC10442; p55-Blk; b lymphocyte kinase; BLK nonreceptor tyrosine kinase; MODY11|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
blk involved in several pathways and played different roles in them. We selected most pathways blk participated on our site, such as Adaptive Immune System, Alpha-synuclein signaling, Antigen activates B Cell Receptor (BCR) leading to generation of second messengers, which may be useful for your reference. Also, other proteins which involved in the same pathway with blk were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Adaptive Immune System||AP1G1; SPSB4; ASB4; UBE2J2; LILRA2; MGC174155; CD96; NPEPPS; DCTN2; ASB2|
|Alpha-synuclein signaling||BLK; STUB1; PARK7; FKBP1A; TOR1A; CSNK2A1; KLK6|
|Antigen activates B Cell Receptor (BCR) leading to generation of second messengers||IGKC; ITPR2; AKR1C1; STIM1B; IGLC2; IGKV1-5; BLK; PIK3AP1; IGHM; AHCYL1|
|Apoptosis Modulation and Signaling||PTRH2; PTPN13; CDKN2A; CAPNS1; SEPT4; BLK; DIABLO; CRADD; DAXX; DFFA|
|B Cell Receptor Signaling Pathway||GSK3AB; CD81; ARPC2; CDK6; cgr2b; LILRB3; LAT2; NFATC2; DUSP4; CD79B|
|CXCR4-mediated signaling events||CSK; PAG1; ADRBK1; MAPKAP1; JAK2; GNA13; CFL1; CRK; GNB2L1; ARR3|
|Class I PI3K signaling events||BLK; ITK; PLEKHA1; ADAP1; ARF1|
|EPHA forward signaling||BLK; EPHA2; EFNA3; EFNA1; EFNA2; ARHGEF15; CRKL; EFNA5|
blk has several biochemical functions, for example, ATP binding, non-membrane spanning protein tyrosine kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by blk itself. We selected most functions blk had, and list some proteins which have the same functions with blk. You can find most of the proteins on our site.
|ATP binding||AACS; GRK7; ASCC3; SLC22A5; KHK; CCT6A; SMC1B; MAP3K3; AXL; PRKACB|
|non-membrane spanning protein tyrosine kinase activity||FES; JAK2A; JAK1; BLK; PTK6B; JAK2; ABL1; SYK; FYNA; PRKCD|
|protein binding||NOS3; CDKN3; EXOC7; LATS1; LHX9; EIF4H; SLC39A7; SEPT7; IRS2; POP1|
|protein tyrosine kinase activity||PTK6B; FYNB; TESK2; IGF1R; JAK2; INSR; DYRK1A; DYRK4; ZNF143B; PTK2B|
|receptor binding||FGF6A; CROT; HLA-A; ABCA1; IFNL3; HLA-E; INSL4; FLT3LG; LRRC4B; CSK|
blk has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with blk here. Most of them are supplied by our site. Hope this information will be useful for your research of blk.
EGFR; 80125; STAT3; EFS; saicar; ERBB2; MET; AR; KIT