Recombinant Human B Lymphoid Tyrosine Kinase, His-tagged

• Cat.No.: BLK-5368H
• Product Overview: Recombinant HumanBLK with His Tag. BLK is a non-receptor tyrosine kinase that belongs to theSrc family of kinases. BLK plays an important role in B-cell activation.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Description: Tyrosine-proteinkinase BLK also known as B lymphocyte kinase is an enzyme that in humans isencoded by the BLK gene. This gene encodes a nonreceptor tyrosine-kinase ofthe src family of proto-oncogenes that are typically involved in cellproliferation and differentiation. The protein has a role in B-cell receptorsignaling and B-cell development.
• Form: Liquid in 50 mMTris, pH 7.5 + 100 mM NaCl + 0.1 mM EDTA + 0.05% NP-40 + 5 mM DTT + 50%glycerol.
• MolecularWeight: 62.3 kDa
• Concentration: 0.39 mg/ml
• Storage: Stable for 6 monthsat -80°C. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: BLK
• Pathways: Alpha-synucleinsignaling; B Cell Receptor Signaling Pathway; CXCR4-mediated signalingevents; Class I PI3K signaling events; EPHA forward signaling; Ephrin Breverse signaling; Focal Adhesion; Glypican 1 network; IL-7 SignalingPathway; PDGFR-beta signaling pathway; Regulation of p38-alpha and p38-beta;Signaling events mediated by PTP1B; Thromboxane A2 receptor signaling;Thromboxane A2 receptor signaling

Gene Information

• Gene Name: BLK B lymphoid tyrosine kinase [ Homosapiens ]
• Synonyms: BLK; Blymphoid tyrosine kinase; MODY11; MGC10442; tyrosine-proteinkinase Blk; p55-Blk; OTTHUMP00000115909; OTTHUMP00000229490; b lymphocytekinase; BLK nonreceptor tyrosine kinase; EC 2.7.10.2; Tyrosine-protein kinase Blk
• Gene ID: 640
• mRNA Refseq: NM_001715
• Protein Refseq: NP_001706
• MIM: 191305
• UniProt ID: P51451
• Chromosome Location: 8p23-p22
• Function: ATP binding;non-membrane spanning protein tyrosine kinase activity; nucleotide binding;protein tyrosine kinase activity