Active Recombinant Mouse BMP-4

• Cat.No.: Bmp4-583M
• Product Overview: BMP-4 Mouse Recombinant produced in E.coli is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor.

Specification

• Species: Mouse
• Source: E.coli
• Tag: Non
• Protein Length: 303-408 a.a.
• Description: Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva
• Bio-activity: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-15 ng/ml.
• AA Sequence: KKNKNCRRHS LYVDFSDVGW NDWIVAPPGY QAFYCHGDCP FPLADHLNST NHAIVQTLVN SVNSSIPKAC CVPTELSAIS MLYLDEYDKV VLKNYQEMVV EGCGCRKKNK NCRRHSLYVD FSDVGWNDWI VAPPGYQAFY CHGDCPFPLA DHLNSTNHAI VQTLVNSVNS SIPKACCVPT ELSAISMLYL DEYDKVVLKN YQEMVVEGCG CR
• Purity: Greater than 98% by SDS-PAGE gel and HPLC analyses.
• Full Length: Full L.

Gene Information

• Gene Name: Bmp4 bone morphogenetic protein 4 [ Mus musculus ]
• Official Symbol: Bmp4
• Synonyms: BMP4; bone morphogenetic protein 4; BMP-2B; bone morphogenetic protein 2B; Bmp-4; Bmp2b; Bmp2b1; Bmp2b-1
• Gene ID: 12159
• mRNA Refseq: NM_007554
• Protein Refseq: NP_031580
• Pathway: Adipogenesis, organism-specific biosystem; Basal cell carcinoma, organism-specific biosystem; Basal cell carcinoma, conserved biosystem; ESC Pluripotency Pathways, organism-specific biosystem; Hedgehog signaling pathway, organism-specific biosystem; Hedgehog signaling pathway, conserved biosystem; Pathways in cancer, organism-specific biosystem
• Function: BMP receptor binding; chemoattractant activity; cytokine activity; growth factor activity; heparin binding; protein binding; protein homodimerization activity