CA14
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Official Full Name
carbonic anhydrase XIV
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Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization.CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. -
Synonyms
CA14; carbonic anhydrase XIV; carbonic anhydrase 14; CA 14; CA XIV; Carbonate dehydratase XIV; CAXIV; UNQ690/PRO1335; CA-XIV; carbonic dehydratase; CAR14; AW536446;
- Recombinant Proteins
- Cell & Tissue Lysates
- Antibody
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Rabbit
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
CA14 involved in several pathways and played different roles in them. We selected most pathways CA14 participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA14 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | CA9;CA14;CA4B;GLUD1B;GLUL;CAR3;CA5A;GLUD1;Car14 |
CA14 has several biochemical functions, for example, carbonate dehydratase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA14 itself. We selected most functions CA14 had, and list some proteins which have the same functions with CA14. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CA5;CA5A;CA3;CA7;CAR6;CAR1;CA12;CA8;Car9 |
| metal ion binding | ENPP4;PRKCHA;RNF11A;ATP13A3;CALM4;ZFP526;APLF;RACGAP1;TRIM71 |
CA14 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA14 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA14.
ZNF273
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Q&As (7)
Ask a questionSpecific modulators can be identified through high-throughput screening assays targeting CA14 and validated using in vitro and in vivo models.
CA14's unique functional attributes can be discerned using comparative enzymatic assays and structural analyses against other isoforms.
Influence of pH or ions on CA14 can be analyzed using enzymatic assays under varying conditions and ion-sensitive probes.
Disease associations can be determined through genetic studies, patient tissue analyses, and literature reviews focusing on CA14's relevance in pathological conditions.
Predominant tissue or cell-type expression can be determined using tissue microarrays, qPCR, or proteomic databases, correlating findings with potential physiological implications.
Consequences of overexpression or knockdown can be assessed using phenotypic analyses, cellular viability assays, and in vivo studies in organisms with altered CA14 expression.
CA14's role in cellular pathways can be explored using pathway enrichment analyses, proteomic studies, and pathway-specific assays in CA14-modified cells.
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