Creative BioMart to Present at
                        BIO-Europe Spring Creative BioMart to Present at IMMUNOLOGY2024™|May 3-7, 2024|Booth #512

Recombinant Human CA14, GST-tagged

Cat.No. : CA14-10617H
Product Overview : Recombinant Human CA14 protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.
Unit
Price
Qty
  • Specification
  • Gene Information
  • Related Products
  • Download
Description : Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles.
Source : E.coli
Species : Human
Tag : GST
Protein length : 19-293a.a.
Storage : The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
Storage Buffer : 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.
Gene Name : CA14 carbonic anhydrase XIV [ Homo sapiens ]
Official Symbol : CA14
Synonyms : CA14; carbonic anhydrase XIV; carbonic anhydrase 14; CA-XIV; carbonic dehydratase; carbonate dehydratase XIV; CAXiV;
Gene ID : 23632
mRNA Refseq : NM_012113
Protein Refseq : NP_036245
MIM : 604832
UniProt ID : Q9ULX7
Chromosome Location : 1q21
Function : carbonate dehydratase activity; lyase activity; metal ion binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

Inquiry

  • Q&As
  • Reviews

Q&As (7)

Ask a question
Are there any known small molecule modulators specific to CA14's activity? 10/16/2022

Specific modulators can be identified through high-throughput screening assays targeting CA14 and validated using in vitro and in vivo models.

What unique functional attributes differentiate CA14 from other carbonic anhydrase isoforms? 02/14/2022

CA14's unique functional attributes can be discerned using comparative enzymatic assays and structural analyses against other isoforms.

How do changes in cellular pH or ion concentrations influence CA14 activity? 09/26/2020

Influence of pH or ions on CA14 can be analyzed using enzymatic assays under varying conditions and ion-sensitive probes.

Are there any known disease associations where CA14 mutations or dysregulation play a pivotal role? 05/02/2020

Disease associations can be determined through genetic studies, patient tissue analyses, and literature reviews focusing on CA14's relevance in pathological conditions.

In what tissues or cell types is CA14 predominantly expressed, and how does this correlate with its physiological role? 09/17/2019

Predominant tissue or cell-type expression can be determined using tissue microarrays, qPCR, or proteomic databases, correlating findings with potential physiological implications.

What are the consequences of CA14 overexpression or knockdown in cellular and organismal models? 02/16/2018

Consequences of overexpression or knockdown can be assessed using phenotypic analyses, cellular viability assays, and in vivo studies in organisms with altered CA14 expression.

Are there specific cellular pathways where CA14 plays a crucial modulatory role? 07/15/2017

CA14's role in cellular pathways can be explored using pathway enrichment analyses, proteomic studies, and pathway-specific assays in CA14-modified cells.

Customer Reviews (3)

Write a review
Reviews
08/19/2022

    Reliable source, ensures reproducibility in our research.

    11/10/2020

      Efficient services, optimize our protein-related studies.

      10/01/2020

        Responsive customer support, aids in problem-solving effectively.

        Ask a Question for All CA14 Products

        Required fields are marked with *

        My Review for All CA14 Products

        Required fields are marked with *

        0

        Inquiry Basket

        cartIcon
        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /

        Stay Updated on the Latest Bioscience Trends