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  • Official Full Name

    carbonic anhydrase IV

  • Overview

    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.
  • Synonyms

    CA4; carbonic anhydrase IV; retinitis pigmentosa 17 (autosomal dominant) , RP17; carbonic anhydrase 4; CAIV; Car4; CA IV; Carbonate dehydratase IV; Carbonic dehydratase; Carbonic dehydratase IV; EC; Retinitis pigmentosa 17 (autosomal dominant); RP17; CA-IV; AW456718;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • MYC
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA4-10621H Recombinant Human CA4, GST-tagged E.coli GST 16-281a.a.
Human CA4-237H Recombinant Human CA4 Protein(Met1-Lys283), His-tagged CHO C-His Met1-Lys283
Human CA4-0240H Recombinant Human CA4 Protein, GST-Tagged Wheat Germ GST
Human CA4-7835H Recombinant Human CA4 protein, His-tagged E.coli His Ala19~Lys283 (Accession # P22748)
Human CA4-3839H Recombinant Human CA4, His tagged Human Cell His
Human CA4-812H Recombinant Human CA4 Protein E.coli N/A
Human CA4-001HCL Recombinant Human CA4 cell lysate CHO N/A
Human CA4-2069HCL Recombinant Human CA4 cell lysate Human Cell N/A
Human CA4-115H Recombinant Human CA4 Protein, His-tagged HEK293 His 312
Human CA4-2271H Recombinant Human CA4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CA4-2739HF Recombinant Full Length Human CA4 Protein, GST-tagged In Vitro Cell Free System GST 312 amino acids
Human CA4-0843H Recombinant Human CA4 Protein (Ala19-Lys283), C-His tagged E.coli C-His Ala19-Lys283
Human CA4-237HB Recombinant Human CA4 Protein(Met1-Lys283), His-tagged, Amine-Labeled Biotinylated CHO C-His Met1-Lys283
Mouse Car4-263M Recombinant Mouse Carbonic Anhydrase 4, His-tagged HEK293 His
Mouse Car4-7836M Recombinant Mouse Car4 protein, His-tagged E.coli His Gly21~Ser216 (Accession # Q64444)
Mouse CA4-2501MCL Recombinant Mouse CA4 cell lysate Human Cell N/A
Mouse Car4-767M Recombinant Mouse Car4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat CAR4-1133R Recombinant Rat CAR4 Protein Mammalian Cell His
Rat CA4-718R Recombinant Rat CA4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Car4-364R Recombinant Rat Car4 Protein, His-tagged E.coli N-His Ser20-Ser220
Rat CA4-718R-B Recombinant Rat CA4 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CA4 involved in several pathways and played different roles in them. We selected most pathways CA4 participated on our site, such as Nitrogen metabolism, Proximal tubule bicarbonate reclamation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismGLUL;CAR15;CA3;GLULA;GLUD1B;CAR1;CA4;GLULB;CA5A
Proximal tubule bicarbonate reclamationPCK2;GLS2;Car4;GLS;SLC4A4;FXYD2;CA4;ATP1B1;AQP1

CA4 has several biochemical functions, for example, carbonate dehydratase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA4 itself. We selected most functions CA4 had, and list some proteins which have the same functions with CA4. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCAR3;CA7;CA5A;CA15A;CA9;CAR13;Car8;CA4A;CA14
protein bindingSOX14;C1QL1;HSP90B1;BCL6;CRHR2;TP73;BLCAP;C12orf5;TIMELESS

CA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA4.


Research Area

Related articles

Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
Cheal, SM; Yoo, B; et al. Evaluation of Glycodendron and Synthetically Modified Dextran Clearing Agents for Multistep Targeting of Radioisotopes for Molecular Imaging and Radioimmunotherapy. MOLECULAR PHARMACEUTICS 11:400-416(2014).
  • Q&As
  • Reviews

Q&As (7)

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What role does CA4 play in the respiratory system? 03/15/2021

CA4 assists in CO2 and bicarbonate regulation, pivotal for efficient respiratory gas exchange.

Which tissues or cell types predominantly express CA4? 06/14/2020

CA4 is highly expressed in the kidney and red blood cells.

What is the primary physiological function of CA4? 01/05/2019

CA4 catalyzes the reversible hydration of carbon dioxide, helping regulate pH and CO2 transport.

What are the known post-translational modifications on CA4? 11/12/2017

Typical modifications like phosphorylation can be identified using techniques such as mass spectrometry.

Is CA4 implicated in any specific cellular signaling pathways? 11/11/2017

While primarily enzymatic, any signaling roles for CA4 would require deeper investigation.

Are there known diseases or conditions associated with CA4 mutations or dysregulation? 04/20/2017

CA4 dysregulation could relate to renal disorders or hematological abnormalities, though research is ongoing.

How does the enzymatic activity of CA4 compare to other carbonic anhydrase family members? 01/09/2017

CA4, like other isoforms, is involved in CO2 hydration, but its specific efficiency and affinity might vary.

Customer Reviews (3)

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      Cost-effective quantitation services, a great research investment.


        Invaluable for our protein analysis and quantification endeavors.

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