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Official Full Name carbonic anhydrase IV
Background Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport.
Synonyms CA4; carbonic anhydrase IV; retinitis pigmentosa 17 (autosomal dominant) , RP17; carbonic anhydrase 4; CAIV; Car4; CA IV; Carbonate dehydratase IV; Carbonic dehydratase; Carbonic dehydratase IV; EC; Retinitis pigmentosa 17 (autosomal dominant); RP17; CA-IV; AW456718
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CA4-001HCL Recombinant Human CA4 cell lysate CHO N/A
    Human CA4-0240H Recombinant Human CA4 Protein, GST-Tagged Wheat Germ GST
    Human CA4-10621H Recombinant Human CA4, GST-tagged E.coli GST
    Human CA4-2069HCL Recombinant Human CA4 cell lysate Human Cell N/A
    Human CA4-2271H Recombinant Human CA4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CA4-237H Recombinant Human CA4, His-tagged CHO His
    Human CA4-3839H Recombinant Human CA4, His tagged Human Cell His
    Human CA4-7835H Recombinant Human CA4 protein, His-tagged E.coli His
    Human CA4-812H Recombinant Human CA4 Protein E.coli N/A
    Mouse CA4-2501MCL Recombinant Mouse CA4 cell lysate Human Cell N/A
    Mouse Car4-263M Recombinant Mouse Carbonic Anhydrase 4, His-tagged HEK293 His
    Mouse Car4-662M Recombinant Mouse Car4, His tagged Human Cell His
    Rat CAR4-1133R Recombinant Rat CAR4 Protein Mammalian Cell His

    ca4 involved in several pathways and played different roles in them. We selected most pathways ca4 participated on our site, such as Nitrogen metabolism, Proximal tubule bicarbonate reclamation, which may be useful for your reference. Also, other proteins which involved in the same pathway with ca4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Nitrogen metabolism CAR7; GLULC; Car14; GLUD1; CA1; Car4; CA4B; CA9; CA6; CA7
    Proximal tubule bicarbonate reclamation ATP1B1; Car4; FXYD2; ATP1A1; CA2; PCK2; Car2; ATP1A2; CA4; SLC38A3

    ca4 has several biochemical functions, for example, carbonate dehydratase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ca4 itself. We selected most functions ca4 had, and list some proteins which have the same functions with ca4. You can find most of the proteins on our site.

    Function Related Protein
    carbonate dehydratase activity Car4; CA5B; CA5; CAHZ; CAR3; CA6; CA8; CA4; CA4A; CA15C
    protein binding EFNA3; CAND2; CNTNAP1; PEX26; RNF170; FAM46C; PTK7; YAP1; ING2; EMD
    zinc ion binding JADE1; MID2; MME; PHF19; USP16; XAF1; CA13; ZFPL1; QPCT; NR5A2

    ca4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ca4 here. Most of them are supplied by our site. Hope this information will be useful for your research of ca4.

    SLC4A4; PRDX2; PIH1D1; HTT

    Davidov, T; Nagar, M; et al. Carbonic anhydrase 4 and crystallin alpha-B immunoreactivity may distinguish benign from malignant thyroid nodules in patients with indeterminate thyroid cytology. JOURNAL OF SURGICAL RESEARCH 190:565-574(2014).
    Cheal, SM; Yoo, B; et al. Evaluation of Glycodendron and Synthetically Modified Dextran Clearing Agents for Multistep Targeting of Radioisotopes for Molecular Imaging and Radioimmunotherapy. MOLECULAR PHARMACEUTICS 11:400-416(2014).

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