CA4
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Official Full Name
carbonic anhydrase IV
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Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. -
Synonyms
CA4; carbonic anhydrase IV; retinitis pigmentosa 17 (autosomal dominant) , RP17; carbonic anhydrase 4; CAIV; Car4; CA IV; Carbonate dehydratase IV; Carbonic dehydratase; Carbonic dehydratase IV; EC 4.2.1.1; Retinitis pigmentosa 17 (autosomal dominant); RP17; CA-IV; AW456718;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CA4 involved in several pathways and played different roles in them. We selected most pathways CA4 participated on our site, such as Nitrogen metabolism, Proximal tubule bicarbonate reclamation, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | CAR1;CA14;Car2;CAR3;Car8;Car14;CA1;CA5;CA8 |
| Proximal tubule bicarbonate reclamation | ATP1B4;SLC9A3;ATP1B2;GLUD1;Car2;ATP1A4;GLUD2;GLS2;SLC38A3 |
CA4 has several biochemical functions, for example, carbonate dehydratase activity, protein binding, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA4 itself. We selected most functions CA4 had, and list some proteins which have the same functions with CA4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CA4;CAR13;Car8;CA5A;Car14;CAR1;CAR7;Car4;CA5B |
| protein binding | LEO1;KRT38;VLDLR;GDI2;DDC;REXO1L1;GOLPH3;EIF4E;IKBIP |
| zinc ion binding | RNF144AA;PNMA3;RNF123;EHMT1B;RNFT2;ZNRD1;TRIM35-34;KDM4A;APOBEC3H |
CA4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA4 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA4.
SLC4A4; PRDX2; PIH1D1; HTT
Research Area
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Q&As (7)
Ask a questionCA4 assists in CO2 and bicarbonate regulation, pivotal for efficient respiratory gas exchange.
CA4 is highly expressed in the kidney and red blood cells.
CA4 catalyzes the reversible hydration of carbon dioxide, helping regulate pH and CO2 transport.
Typical modifications like phosphorylation can be identified using techniques such as mass spectrometry.
While primarily enzymatic, any signaling roles for CA4 would require deeper investigation.
CA4 dysregulation could relate to renal disorders or hematological abnormalities, though research is ongoing.
CA4, like other isoforms, is involved in CO2 hydration, but its specific efficiency and affinity might vary.
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