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Recombinant Human CA4 Protein, GST-Tagged

Cat.No. : CA4-0240H
Product Overview : Human CA4 full-length ORF (AAH57792, 19 a.a. - 312 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. This gene encodes a glycosylphosphatidyl-inositol-anchored membrane isozyme expressed on the luminal surfaces of pulmonary (and certain other) capillaries and proximal renal tubules. Its exact function is not known; however, it may have a role in inherited renal abnormalities of bicarbonate transport. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 58.08 kDa
AA Sequence : AESHWCYEVQAESSNYPCLVPVKWG GNCQKDRQSPINIVTTKAKVDKKLG RFFFSGYDKKQTWTVQNNGHSVMML LENKASISGGGLPAPYQAKQLHLHW SDLPYKGSEHSLDGEHFAMEMHIVH EKEKGTSRNVKEAQDPEDEIAVLAF LVEAGTQVNEGFQPLVEALSNIPKP EMSTTMAESSLLDLLPKEEKLRHYF RYLGSLTTPTCDEKVVWTVFREPIQ LHREQILAFSQKLYYDKEQTVSMKD NVRPLQQLGQRTVIKSGAPGRPLPW ALPALLGPMLACLLAGFLR
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CA4 carbonic anhydrase IV [ Homo sapiens ]
Official Symbol : CA4
Synonyms : CA4; carbonic anhydrase IV; retinitis pigmentosa 17 (autosomal dominant), RP17; carbonic anhydrase 4; CAIV; Car4; CA-IV; carbonic dehydratase IV; carbonate dehydratase IV; RP17;
Gene ID : 762
mRNA Refseq : NM_000717
Protein Refseq : NP_000708
MIM : 114760
UniProt ID : P22748

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What role does CA4 play in the respiratory system? 03/15/2021

CA4 assists in CO2 and bicarbonate regulation, pivotal for efficient respiratory gas exchange.

Which tissues or cell types predominantly express CA4? 06/14/2020

CA4 is highly expressed in the kidney and red blood cells.

What is the primary physiological function of CA4? 01/05/2019

CA4 catalyzes the reversible hydration of carbon dioxide, helping regulate pH and CO2 transport.

What are the known post-translational modifications on CA4? 11/12/2017

Typical modifications like phosphorylation can be identified using techniques such as mass spectrometry.

Is CA4 implicated in any specific cellular signaling pathways? 11/11/2017

While primarily enzymatic, any signaling roles for CA4 would require deeper investigation.

Are there known diseases or conditions associated with CA4 mutations or dysregulation? 04/20/2017

CA4 dysregulation could relate to renal disorders or hematological abnormalities, though research is ongoing.

How does the enzymatic activity of CA4 compare to other carbonic anhydrase family members? 01/09/2017

CA4, like other isoforms, is involved in CO2 hydration, but its specific efficiency and affinity might vary.

Customer Reviews (3)

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Reviews
04/14/2022

    Reliable partner for protein expression and analysis.

    04/12/2022

      Cost-effective quantitation services, a great research investment.

      12/09/2020

        Invaluable for our protein analysis and quantification endeavors.

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