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  • Official Full Name

    carbonic anhydrase VA, mitochondrial

  • Overview

    Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization.CA VA is localized in the mitochondria and expressed primarily in the liver.It may play an important role in ureagenesis and gluconeogenesis.CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2.
  • Synonyms

    CA5A; carbonic anhydrase VA, mitochondrial; CA5; carbonic anhydrase 5A, mitochondrial; CAV; CAVA; CA VA; Carbonate dehydratase VA; carbonic anhydrase 5A mitochondrial; carbonic anhydrase V mitochondrial; Carbonic anhydrase VA; Carbonic anhydrase VA mitochondrial; carbonic anhydrase VA mitochondrial1; carbonic dehydratase; CA-VA; carbonic anhydrase V, mitochondrial; Car5;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CA5A-719H Active Recombinant Human CA5A protein, His-tagged E.coli His Ala40-Ser305
Human CA5A-1142H Recombinant Human CA5A, His tagged E.coli His
Human CA5A-0242H Recombinant Human CA5A Protein, GST-Tagged Wheat Germ GST
Human CA5A-2269H Recombinant Human CA5A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CA5A-5924H Recombinant Human CA5A protein, His-tagged HEK293 His 39-305aa
Human CA5A-2562H Recombinant Human CA5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CA5A-2740HF Recombinant Full Length Human CA5A Protein, GST-tagged In Vitro Cell Free System GST 305 amino acids
Mouse CAR5A-2721M Recombinant Mouse CAR5A Protein Mammalian Cell His
Mouse Car5a-7850M Recombinant Mouse Car5a protein, His-tagged E.coli His Arg7~Lys179 (Accession # P23589)
Mouse Car5a-768M Recombinant Mouse Car5a Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CA5a-1160M Recombinant Mouse CA5a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CA5a-1160M-B Recombinant Mouse CA5a Protein Pre-coupled Magnetic Beads HEK293
Rat CAR5A-1134R Recombinant Rat CAR5A Protein Mammalian Cell His
Rat Ca5a-7851R Recombinant Rat Ca5a protein, His-tagged E.coli His Tyr12~Leu219 (Accession # P43165)
Rat CA5a-719R-B Recombinant Rat CA5a Protein Pre-coupled Magnetic Beads HEK293
Rat CA5a-719R Recombinant Rat CA5a Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CA5A Related Articles

CA5A involved in several pathways and played different roles in them. We selected most pathways CA5A participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Nitrogen metabolismCAR7;GLUD1B;GLULA;CA12;CAR5A;CAR13;CAR1;CA8;CA13

CA5A has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA5A itself. We selected most functions CA5A had, and list some proteins which have the same functions with CA5A. You can find most of the proteins on our site.

Function Related Protein
carbonate dehydratase activityCar9;Car8;CA5;CA6;Car14;CA3;Car12;CA7;CAR6

CA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of CA5A.

Tanc, M; Carta, F; et al. 6-Substituted 1,2-benzoxathiine-2,2-dioxides are isoform-selective inhibitors of human carbonic anhydrases IX, XII and VA. ORGANIC & BIOMOLECULAR CHEMISTRY 13:77-80(2015).
Durdagi, S; Scozzafava, G; et al. Inhibition of mammalian carbonic anhydrases I-XIV with grayanotoxin III: solution and in silico studies. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 29:469-475(2014).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What post-translational modifications are observed in CA5A? 12/05/2022

Post-translational modifications of CA5A can be identified using mass spectrometry, with potential phosphorylation or acetylation sites.

What diseases or conditions are associated with CA5A dysregulation? 06/30/2022

Dysregulation of CA5A might influence metabolic processes in the liver, potentially impacting conditions like fatty liver disease or other metabolic disorders.

Are there genetic mutations in the CA5A gene that impact its function? 11/15/2021

Specific mutations might affect CA5A's stability or activity, necessitating functional assays for validation.

Are there specific compounds known to inhibit or activate CA5A activity? 04/29/2021

While general carbonic anhydrase inhibitors might affect CA5A, specific modulators would need further research.

What is the primary function of CA5A in cellular processes? 04/24/2021

CA5A facilitates the reversible conversion of CO2 to bicarbonate and protons, playing a role in pH regulation and CO2 transport.

How does CA5A's enzymatic activity compare with other carbonic anhydrase isoforms? 10/26/2018

CA5A's activity is tailored to its mitochondrial environment, which might differ in kinetics from cytosolic isoforms.

How does the expression profile of CA5A differ among human tissues? 12/21/2017

CA5A is primarily expressed in the mitochondria of liver cells, with lesser amounts in other tissues.

Customer Reviews (3)

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