CA5A
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Official Full Name
carbonic anhydrase VA, mitochondrial
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Overview
Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide.They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid.They show extensive diversity in tissue distribution and in their subcellular localization.CA VA is localized in the mitochondria and expressed primarily in the liver.It may play an important role in ureagenesis and gluconeogenesis.CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. -
Synonyms
CA5A; carbonic anhydrase VA, mitochondrial; CA5; carbonic anhydrase 5A, mitochondrial; CAV; CAVA; CA VA; Carbonate dehydratase VA; carbonic anhydrase 5A mitochondrial; carbonic anhydrase V mitochondrial; Carbonic anhydrase VA; Carbonic anhydrase VA mitochondrial; carbonic anhydrase VA mitochondrial1; carbonic dehydratase; CA-VA; carbonic anhydrase V, mitochondrial; Car5;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E. coli
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- C
- His
- GST
- Fc
- Avi
- Myc
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
CA5A involved in several pathways and played different roles in them. We selected most pathways CA5A participated on our site, such as Nitrogen metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Nitrogen metabolism | GLUL;CA6;CAR5A;GLULB;CA4B;CA2;CA5B;GLULA;CAR1 |
CA5A has several biochemical functions, for example, carbonate dehydratase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA5A itself. We selected most functions CA5A had, and list some proteins which have the same functions with CA5A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| carbonate dehydratase activity | CA5B;Car2;CAR7;CAR3;CAR5A;CA1;CA4;Car8;CA5A |
| zinc ion binding | GATA4;PEG10;MSRB3;EHMT2;ALPI;ZFAND3;ADAMTS3;ZDHHC15;THRB |
CA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of CA5A.
Research Area
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Q&As (7)
Ask a questionPost-translational modifications of CA5A can be identified using mass spectrometry, with potential phosphorylation or acetylation sites.
Dysregulation of CA5A might influence metabolic processes in the liver, potentially impacting conditions like fatty liver disease or other metabolic disorders.
Specific mutations might affect CA5A's stability or activity, necessitating functional assays for validation.
While general carbonic anhydrase inhibitors might affect CA5A, specific modulators would need further research.
CA5A facilitates the reversible conversion of CO2 to bicarbonate and protons, playing a role in pH regulation and CO2 transport.
CA5A's activity is tailored to its mitochondrial environment, which might differ in kinetics from cytosolic isoforms.
CA5A is primarily expressed in the mitochondria of liver cells, with lesser amounts in other tissues.
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