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Recombinant Human CA5A Protein, GST-Tagged

Cat.No. : CA5A-0242H
Product Overview : Human CA5A full-length ORF (NP_001730.1, 1 a.a. - 305 a.a.) recombinant protein with GST-tag at N-terminal.
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Description : Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA VA is localized in the mitochondria and expressed primarily in the liver. It may play an important role in ureagenesis and gluconeogenesis. CA5A gene maps to chromosome 16q24.3 and an unprocessed pseudogene has been assigned to 16p12-p11.2. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 61.2 kDa
AA Sequence : MLGRNTWKTSAFSFLVEQMWAPLWS RSMRPGRWCSQRSCAWQTSNNTLHP LWTVPVSVPGGTRQSPINIQWRDSV YDPQLKPLRVSYEAASCLYIWNTGY LFQVEFDDATEASGISGGPLENHYR LKQFHFHWGAVNEGGSEHTVDGHAY PAELHLVHWNSVKYQNYKEAVVGEN GLAVIGVFLKLGAHHQTLQRLVDIL PEIKHKDARAAMRPFDPSTLLPTCW DYWTYAGSLTTPPLTESVTWIIQKE PVEVAPSQLSAFRTLLFSALGEEEK MMVNNYRPLQPLMNRKVWASFQATN EGTRS
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : CA5A carbonic anhydrase VA, mitochondrial [ Homo sapiens ]
Official Symbol : CA5A
Synonyms : CA5A; carbonic anhydrase VA, mitochondrial; CA5; carbonic anhydrase 5A, mitochondrial; CAV; CAVA; CA-VA; carbonic dehydratase; carbonate dehydratase VA; carbonic anhydrase V, mitochondrial;
Gene ID : 763
mRNA Refseq : NM_001739
Protein Refseq : NP_001730
MIM : 114761
UniProt ID : P35218

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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What post-translational modifications are observed in CA5A? 12/05/2022

Post-translational modifications of CA5A can be identified using mass spectrometry, with potential phosphorylation or acetylation sites.

What diseases or conditions are associated with CA5A dysregulation? 06/30/2022

Dysregulation of CA5A might influence metabolic processes in the liver, potentially impacting conditions like fatty liver disease or other metabolic disorders.

Are there genetic mutations in the CA5A gene that impact its function? 11/15/2021

Specific mutations might affect CA5A's stability or activity, necessitating functional assays for validation.

Are there specific compounds known to inhibit or activate CA5A activity? 04/29/2021

While general carbonic anhydrase inhibitors might affect CA5A, specific modulators would need further research.

What is the primary function of CA5A in cellular processes? 04/24/2021

CA5A facilitates the reversible conversion of CO2 to bicarbonate and protons, playing a role in pH regulation and CO2 transport.

How does CA5A's enzymatic activity compare with other carbonic anhydrase isoforms? 10/26/2018

CA5A's activity is tailored to its mitochondrial environment, which might differ in kinetics from cytosolic isoforms.

How does the expression profile of CA5A differ among human tissues? 12/21/2017

CA5A is primarily expressed in the mitochondria of liver cells, with lesser amounts in other tissues.

Customer Reviews (3)

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Reviews
08/26/2022

    Efficient protein quantification, saves time and resources.

    01/15/2022

      Consistency in results, a symbol of their service quality.

      05/25/2021

        Top-tier protein sequencing, propels our research forward.

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