This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
CCL17; A-152E5.3; ABCD-2; MGC138271; MGC138273; SCYA17; TARC; CC chemokine TARC; C-C motif chemokine; chemokine (C-C motif) ligand 17; small inducible cytokine subfamily A (Cys-Cys), member 17; Small-inducible cytokine A17; Thymus and activation-regulated chemokine;
CCL17 involved in several pathways and played different roles in them. We selected most pathways CCL17 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CCL17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CCL17 has several biochemical functions, for example, CCR chemokine receptor binding, chemokine activity, receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CCL17 itself. We selected most functions CCL17 had, and list some proteins which have the same functions with CCL17. You can find most of the proteins on our site.
CCL17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCL17 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCL17.
Ma, T; Xu, JC; et al. Combination of C-X-C motif chemokine 9 and C-X-C motif chemokine 10 antibodies with FTY720 prolongs the survival of cardiac retransplantation allografts in a mouse model. EXPERIMENTAL AND THERAPEUTIC MEDICINE 9:1006-1012(2015).
Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).