Active Recombinant Mouse Chemokine (C-C motif) Ligand 22, MIgG2a Fc-tagged, mutant

• Cat.No.: CCL22-3861M
• Product Overview: The extracellular domain of mouse CCL22 (NP_033163.1)(Gly25-Ser92) is fused to the N-terminus of the Fc portion of a mutant mouse IgG2a was expressed in CHO cell.

Specification

• Description: This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are afamily of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines areproteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activityfor monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It alsodisplays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils,eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokinemay play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects ofactivated T lymphocyte physiology.
• Source: CHO cell
• Species: Mouse
• Tag: MIgG2a Fc-tagged, mutant
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by a chemotaxis bioassay using human activated lymphocytes
• Molecular Mass: 34 KDa
• AA Sequence: Gly25-Ser92
• Endotoxin: <0.06 eu/μg as determined by lal test.>
• Purity: ≥98%, by SDS-PAGE under reducing conditions.
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: Ccl22 chemokine (C-C motif) ligand 22 [ Mus musculus ]
• Official Symbol: CCL22
• Synonyms: CCL22; chemokine (C-C motif) ligand 22; C-C motif chemokine 22; CC chemokine ABCD-1; small-inducible cytokine A22; activated B and dendritic cell-derived; small inducible cytokine subfamily A22; dendritic cell and B cell derived chemokine; small inducible cytokine subfamily A, member 22; SMALL INDUCIBLE CYTOKINE A22 PRECURSOR (CC CHEMOKINE ABCD-1) (ACTIVATED B AND DENDRITIC CELL-DERIVED); MDC; DCBCK; ABCD-1; Scya22
• Gene ID: 20299
• mRNA Refseq: NM_009137
• Protein Refseq: NP_033163
• Pathway: Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem
• Function: chemokine activity; cytokine activity