Recombinant Human CCL22 Protein, His-tagged
Cat.No. : | CCL22-311H |
Product Overview : | Recombinant Human CCL22 (O00626) (Gly 25-Gln 93) was expressed, with a polyhistidine tag at the N-terminus. |
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Description : | Chemokine (C-C motif) ligand 22(ABCD-1 / CCL22)is a kind of CC chemokine which is a family of secreted proteins involved in immunoregulatory and inflammatory pr centigradeesses. The cytokine displays chemotactic activity for mon centigradeytes, dendritic cells, natural killer cells and for chronically activated T lymph centigradeytes. It also displays a mild activity for primary activated T lymph centigradeytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymph centigradeytes. This ABCD-1 / CCL22 chemokine binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated / effector T lymph centigradeytes to inflammatory sites and other aspects of activated T-lymph centigradeyte physiology. ABCD-1 / CCL22 is highly expressed in macrophage and in mon centigradeyte-derived dendritic cells, and thymus, and in Langerhans' cell histi centigradeytosis and atopic dermatitis but not in dermatopathic lymphadenopathy. This chemokine is also found in lymph node, appendix, activated mon centigradeytes, resting and activated macrophages. This protein is lower expressed in lung and spleen and very weekly expressed in small intestine. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Predicted N Terminal : | Met |
Form : | Lyophilized from sterile 30% Acetonitrile, 0.1% TFA. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. |
Molecular Mass : | The recombinant human CCL22 consisting of 84 amino acids and has a calculated molecular mass of 9.7 KDa. It migrates as an 10 kDa band in SDS-PAGE under reducing conditions. |
Protein length : | Gly 25-Gln 93 |
Endotoxin : | < 1.0 EU per μg protein as determined by the LAL method. |
Purity : | > 90 % as determined by SDS-PAGE. |
Storage : | Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | CCL22 chemokine (C-C motif) ligand 22 [ Homo sapiens ] |
Official Symbol : | CCL22 |
Synonyms : | CCL22; chemokine (C-C motif) ligand 22; SCYA22, small inducible cytokine subfamily A (Cys Cys), member 22; C-C motif chemokine 22; A 152E5.1; ABCD 1; DC/B CK; MDC; MGC34554; STCP 1; MDC(1-69); CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1; |
Gene ID : | 6367 |
mRNA Refseq : | NM_002990 |
Protein Refseq : | NP_002981 |
MIM : | 602957 |
UniProt ID : | O00626 |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe catalytic activity of CCL22 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value.
This repeatability of CCL22 is very good, which can ensure the safety of the experiment and avoid unnecessary risks.
CCL22 were well suited for our research needs due to their simple storage conditions and long-term preservation.
Q&As (6)
Ask a questionThe expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.
Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.
A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.
The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.
There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.
Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.
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