Recombinant Human CCL22 Protein, His-tagged

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Recombinant Human CCL22 Protein, His-tagged

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Cat.No. : CCL22-311H
Product Overview : Recombinant Human CCL22 (O00626) (Gly 25-Gln 93) was expressed, with a polyhistidine tag at the N-terminus.
Description : Chemokine (C-C motif) ligand 22(ABCD-1 / CCL22)is a kind of CC chemokine which is a family of secreted proteins involved in immunoregulatory and inflammatory pr centigradeesses. The cytokine displays chemotactic activity for mon centigradeytes, dendritic cells, natural killer cells and for chronically activated T lymph centigradeytes. It also displays a mild activity for primary activated T lymph centigradeytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymph centigradeytes. This ABCD-1 / CCL22 chemokine binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated / effector T lymph centigradeytes to inflammatory sites and other aspects of activated T-lymph centigradeyte physiology. ABCD-1 / CCL22 is highly expressed in macrophage and in mon centigradeyte-derived dendritic cells, and thymus, and in Langerhans' cell histi centigradeytosis and atopic dermatitis but not in dermatopathic lymphadenopathy. This chemokine is also found in lymph node, appendix, activated mon centigradeytes, resting and activated macrophages. This protein is lower expressed in lung and spleen and very weekly expressed in small intestine.
Source : E. coli
Species : Human
Tag : His
Predicted N Terminal : Met
Form : Lyophilized from sterile 30% Acetonitrile, 0.1% TFA. Normally 5 %- 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.
Molecular Mass : The recombinant human CCL22 consisting of 84 amino acids and has a calculated molecular mass of 9.7 KDa. It migrates as an 10 kDa band in SDS-PAGE under reducing conditions.
Protein length : Gly 25-Gln 93
Endotoxin : < 1.0 EU per μg protein as determined by the LAL method.
Purity : > 90 % as determined by SDS-PAGE.
Storage : Samples are stable for up to twelve months from date of receipt at-70 centigrade. Store it under sterile conditions at-20 centigrade to-80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4ºC before opening to recover the entire contents.
Gene Name : CCL22 chemokine (C-C motif) ligand 22 [ Homo sapiens ]
Official Symbol : CCL22
Synonyms : CCL22; chemokine (C-C motif) ligand 22; SCYA22, small inducible cytokine subfamily A (Cys Cys), member 22; C-C motif chemokine 22; A 152E5.1; ABCD 1; DC/B CK; MDC; MGC34554; STCP 1; MDC(1-69); CC chemokine STCP-1; macrophage-derived chemokine; small inducible cytokine A22; small-inducible cytokine A22; stimulated T cell chemotactic protein 1; stimulated T-cell chemotactic protein 1; small inducible cytokine subfamily A (Cys-Cys), member 22; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1;
Gene ID : 6367
mRNA Refseq : NM_002990
Protein Refseq : NP_002981
MIM : 602957
UniProt ID : O00626

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