Recombinant Human CCL22 Protein, Biotin-tagged
|Product Overview :||Recombinant Human CCL22 Protein, fused to Biotin-tag, was expressed in E. coli.|
- Gene Information
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|Description :||This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology.|
|Source :||E. coli|
|AA Sequence :||GPYGANMEDS VCCRDYVRYR LPLRVVKHFY WTSDSCPRPG VVLLTFRDKE ICADPRVPWV KMILNKLSQ + Linker|
|tmpcolum67 :||C-C motif chemokine ligand 22|
|Gene Name :||CCL22 C-C motif chemokine ligand 22 [ Homo sapiens (human) ]|
|Official Symbol :||CCL22|
|Synonyms :||MDC; ABCD-1; SCYA22; STCP-1; DC/B-CK; A-152E5.1|
|Gene ID :||6367|
|mRNA Refseq :||NM_002990|
|Protein Refseq :||NP_002981|
|UniProt ID :||O00626|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.
Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.
A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.
The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.
There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.
Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.
Customer Reviews (3)Write a review
The catalytic activity of CCL22 is very strong, which can significantly improve the selectivity and yield of chemical reactions, and has high application value. -
This repeatability of CCL22 is very good, which can ensure the safety of the experiment and avoid unnecessary risks. -
CCL22 were well suited for our research needs due to their simple storage conditions and long-term preservation. -
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