Recombinant Cattle CCL22 protein, His & GST-tagged
|Product Overview :||Recombinant Cattle CCL22 aa. (Met1~Gln93 (Accession # NM_001099162.1)) fused with N-terminal His & GST tag was produced in E. coli cells.|
- Gene Information
- Related Products
|Source :||E. coli|
|Tag :||His & GST|
|Form :||Freeze-dried powder|
|Molecular Mass :||Predicted Molecular Mass: 43.0kDa|
|Protein length :||Met1~Gln93 (Accession # NM_001099162.1)|
|Endotoxin :||<1.0EU per 1µg (determined by the LAL method)|
|Characteristic :||The isoelectric point is 7.6.|
|Applications :||SDS-PAGE; WB; ELISA; IP.|
|Stability :||The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.|
|Storage :||Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.|
|Storage buffer :||Supplied as lyophilized form in PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl.|
|Reconstitution :||Reconstitute in sterile PBS, pH7.2-pH7.4.|
|Gene Name :||CCL22 C-C motif chemokine ligand 22 [ Bos taurus (cattle) ]|
|Official Symbol :||CCL22|
|Synonyms :||small inducible cytokine A22; C-C motif chemokine 22|
|Gene ID :||616996|
|mRNA Refseq :||NM_001099162.2|
|Protein Refseq :||NP_001092632.1|
|UniProt ID :||A5PKF1|
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Q&As (6)Ask a question
The expression of CCL22 gene is regulated by a variety of signaling pathways, including inflammatory factor-mediated signaling pathways, cytokine-mediated signaling pathways, and transcription factors.
Studies have shown that by interfering with the interaction of the CCL22 protein and its receptor CCR4, tumor growth, improve inflammatory response, and regulate autoimmune diseases can be inhibited. These findings provide potential application value for the development of corresponding therapeutic strategies.
A number of inhibitors or antagonists that interact with CCL22 proteins have been developed that block the binding of CCL22 to its receptor CCR4, thereby interfering with its biological function.
The mechanism of action of CCL22 protein in specific diseases can be studied through cell culture experiments, animal models, clinical samples, and related biochemical techniques.
There are complex interactions between CCL22 proteins and other chemokines. They may influence the migration and localization of immune cells by competing for receptors, mutual regulation of expression, etc.
Some studies have shown that in tumor immunotherapy, inhibiting the expression of CCL22 or interfering with its interaction with CCR4 can enhance the effect of immunotherapy and improve the survival rate of patients.
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