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Ccl4

  • Official Full Name

    chemokine (C-C motif) ligand 4

  • Overview

    CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.
  • Synonyms

    Ccl4; chemokine (C-C motif) ligand 4; MIP-1b; MIP 1 beta; Secreted protein G 26; ACT 2; ACT-2; ACT2; AT744.1; CC chemokine ligand 4; CCL4; CCL4_HUMAN; ccl4l 1; CCL4L1; Chemokine CC Motif Ligand 4; G 26 T lymphocyte secreted protein; G-26 T-lymphocyte-secreted protein; HC21; LAG 1; LAG-1; LAG1; Lymphocyte activation gene 1; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1 beta; Macrophage inflammatory protein 1-beta; MGC104418; MGC126025; MGC126026; MIP-1-beta; MIP-1-beta(1-69); MIP-1-beta(3-69); MIP1 beta; MIP1B; MIP1B1; PAT 744; Protein H400; SCYA2; SCYA4; Secreted protein G26; SIS gamma; SIS-gamma; Small inducible cytokine A4; Small-inducible cytokine A4; T cell activation protein 2; T-cell activation protein 2; MIP-1β; Macrophage inflammatory protein-1β;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Atlantic Salmon
  • Canine
  • Cattle
  • Chicken
  • Cotton Rat
  • Cynomolgus Monkey
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • Mammalian Cell
  • S.frugiperda
  • Wheat Germ
  • yeast
  • Yeast
  • Biotin
  • DYKDDDDK
  • Fc
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc
  • DDK
  • N/A
  • N
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCL4-119H Active Recombinant Human Chemokine (C-C Motif) Ligand 4, MIgG2a Fc-tagged CHO Fc
Human CCL4-16H Active Recombinant Human CCL4 yeast N/A
Human CCL4-183H Recombinant Human CCL4 Protein, Mature chain, Tag Free, Biotinylated E.coli Tag Free Mature chain
Human CCL4-185H Active Recombinant Human Chemokine (C-C Motif) Ligand 4, HIgG1 Fc-tagged CHO Fc
Human CCL4-074C Active Recombinant Human CCL4 Protein (69 aa) E.coli 69
Human CCL4-134H Recombinant Human CCL4, Fc-tagged CHO Fc
Human CCL4-10850H Recombinant Human CCL4, GST-tagged E.coli GST 37-74a.a.
Human CCL4-294H Recombinant Human CCL4 protein E.coli N/A 69
Human CCL4-290H Recombinant Human CCL4, StrepII-tagged Human Cell Strep II 24-92, 69 a.a.
Human CCL4-247H Recombinant Human CCL4, His-tagged Yeast His Ala24-Gln92
Human CCL4-159H Recombinant Human Chemokine (C-C motif) Ligand 4 S.frugiperda N/A
Human CCL4-77H Recombinant Human CCL4 Yeast N/A
Human CCL4-710H Recombinant Human CCL4 protein, His & GST-tagged E.coli His/GST Ala24~Asn92 (Accession # P13236)
Human CCL4-0640H Recombinant Human CCL4 Protein, GST-Tagged Wheat Germ GST
Human CCL4-7721HCL Recombinant Human CCL4 293 Cell Lysate HEK293 N/A
Human CCL4-151H Recombinant Human CCL4 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CCL4-2936H Recombinant Human CCL4 Protein E.coli N/A
Human CCL4-6531H Recombinant Human CCL4 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CCL4-79H Recombinant Human CCL4 Protein, Biotin-tagged E.coli Biotin
Human CCL4-1110H Recombinant Human CCL4 Protein, His-tagged HEK293F N-His Ala24-Asn92
Human CCL4-2149H Recombinant Human CCL4 Protein, His-tagged E.coli N-His Ala24-Asn92
Human CCL4-2150H Recombinant Human CCL4 Protein, His-tagged E.coli N-His Ala24-Asn92
Human CCL4-219C Active Recombinant Human CCL4 Protein (69 aa) CHO 69
Human CCL4-1111H Recombinant Human CCL4 Protein, His-tagged HEK293F N-His Ala24-Asn92
Human CCL4-1143H Recombinant Human CCL4 Protein (Met26-Asn92), GST tagged E.coli GST Met26-Asn92
Human CCL4-25H Recombinant Human CCL4 Protein E.coli
Human CCL4-1282H Recombinant Human CCL4 Protein (Ala24-Asn92), N-GST tagged E.coli N-GST Ala24-Asn92
Human CCL4-71H Recombinant Human CCL4 Protein E.coli 70 amino acid
Human CCL4-269H Active Recombinant Human CCL4 Protein (Ala24-Asn92), Animal-free, Carrier-free E.coli Tag Free Ala24-Asn92
Human CCL4-329C Active Recombinant Human CCL4 Protein (69 aa) E.coli 69
Human CCL4-022H Recombinant Human CCL4 Protein 92
Human CCL4-023H Recombinant Human CCL4 Protein, Biotinylated 92
Mouse Ccl4-01M Active GMP Recombinant Mouse Ccl4 Protein, His-Tagged E.coli His
Mouse Ccl4-2038M Active Recombinant Mouse Ccl4 Protein E. coli
Mouse Ccl4-77M Active Recombinant Mouse Ccl4 Protein (Ala24-Asn92), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala24-Asn92
Mouse Ccl4-615M Recombinant Mouse Ccl4 protein E.coli N/A 69
Mouse Ccl4-711M Recombinant Mouse Ccl4 protein, His-tagged E.coli His Ala24~Asn92 (Accession # P14097)
Mouse Ccl4-105M Recombinant Murine Chemokine (C-C Motif) Ligand 4 E.coli N/A
Mouse CCL4-75M Recombinant Mouse CCL4 Yeast N/A
Mouse Ccl4-26M Active Recombinant Mouse CCL4 Protein E.coli
Rat CCL4-1214R Recombinant Rat CCL4 Protein Mammalian Cell His
Rat CCL4-74R Recombinant Rat CCL4 Yeast N/A
Rat Ccl4-634R Recombinant Rat Ccl4 protein E.coli N/A 69
Rat Ccl4-712R Recombinant Rat Ccl4 protein, His-tagged E.coli His Ala24~Asn92 (Accession # P50230)
Rat Ccl4-106R Recombinant Rat Chemokine (C-C Motif) Ligand 4 E.coli N/A
Rat CCL4-872R-B Recombinant Rat CCL4 Protein Pre-coupled Magnetic Beads HEK293
Rat CCL4-872R Recombinant Rat CCL4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CCL4-934R Recombinant Rat CCL4 Protein (Ala24-Asn92), His-tagged Yeast His Ala24-Asn92
Rabbit CCL4-713R Recombinant Rabbit CCL4 protein, His & GST-tagged E.coli His/GST Ala24~Asn92 (Accession# P46632)
Dog CCL4-709D Recombinant Dog CCL4 protein, His & GST-tagged E.coli His/GST Met1~Asn92 (Accession # Q68AZ0)
Atlantic Salmon CCL4-4396A Recombinant Atlantic Salmon CCL4 Protein Yeast N/A 77aa
Canine CCL4-421C Active Recombinant Canine Chemokine (C-C motif) Ligand 4 E.coli N/A
Canine CCL4-631C Active Recombinant Canine CCL4 E.coli N/A
Canine CCL4-76C Recombinant Canine CCL4 Yeast N/A
Cattle CCL4-708C Recombinant Cattle CCL4 protein, His & GST-tagged E.coli His/GST Met1~Asn92 (Accession # Q17QA1)
Cotton Rat Ccl4-386C Active Recombinant Cotton Rat Ccl4 E.coli N/A
Cynomolgus Monkey CCL4-4390C Recombinant Cynomolgus Monkey CCL4 Protein Yeast N/A 69aa
Pig CCL4-146S Recombinant Swine Chemokine (C-C motif) Ligand 4 Yeast N/A
Chicken CCL4-2235C Recombinant Chicken CCL4 Mammalian Cell His
Chicken CCL4-137C Recombinant Chicken Chemokine (C-C motif) Ligand 4 Yeast N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Ccl4 Related Articles
  • Ccl4 Related Gene Family
  • Ccl4 Related Research Area

Ccl4 involved in several pathways and played different roles in them. We selected most pathways Ccl4 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ccl4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFSF18;TNFRSF10C;Ccl21c;CNTF;IFNB;TNFRSF1B;IL1R1;IFNG1-2;IL6
Chemokine signaling pathwayCCL27;CDC42;DOCK2;CCL21;PIK3R1;NFKBIA;GNG11;HRAS;ADRBK2
NF-kappa B signaling pathwayMAP3K7IP3;TNFAIP3;GM13304;LCK;TNFRSF11A;TRAF3;TNF;LRDD;TNFSF14
Toll-like receptor signaling pathwayCCL5;MAPK8A;MAP2K6;MAP2K7;MAP2K2B;RIPK1L;PIK3R1;IFNA10;SPP1
Cytosolic DNA-sensing pathwayPOLR3GL;POLR3GLB;NFKBIA;POLR1C;IRF3;IRF7;POLR1D;POLR2E;POLR3B
Salmonella infectionKLC1A;MAPK9;CDC42L2;KLC4;IL8L2;RAC1;IL1B;MAPK12;CXCL3

Ccl4 has several biochemical functions, for example, CCR1 chemokine receptor binding, CCR5 chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ccl4 itself. We selected most functions Ccl4 had, and list some proteins which have the same functions with Ccl4. You can find most of the proteins on our site.

Function Related Protein
CCR1 chemokine receptor bindingCREB3;CCL4;CCL7;CCL3;CCL23;CCL5
CCR5 chemokine receptor bindingSTAT3;CNIH4;CCL4;CCL3;JAK1;CCL5
chemokine activityCCL11;CCL5;CCL25B;CXCL9;IL-8;XCL2;CCL6;CCL8;CCL21
cytokine activityIFNG1-1;MSTNA;BMP5;THPO;Ccl9;IL37;IL26;IFNE;BMP3
identical protein bindingTMEM115;S100A4;AKT1;ZHX2;APP;MAP1S;NUDT16;TK1;ATL1
protein bindingLINGO1;C7orf50;CTBP2;RFC4;CCDC141;RECQL;CTU2;EIF2B2;CLC

Ccl4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ccl4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ccl4.

SLC30A2; IDE; glgX; rnb

Pauta, M; Ribera, J; et al. Overexpression of angiopoietin-2 in rats and patients with liver fibrosis. Therapeutic consequences of its inhibition. LIVER INTERNATIONAL 35:1383-1392(2015).
He, JB; Wang, H; et al. Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy. JOURNAL OF OPHTHALMOLOGY :-(2015).
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