Recombinant Human Chemokine (C-C motif) Ligand 4

• Cat.No.: CCL4-159H
• Product Overview: Recombinant human macrophage inflammatory protein-1β was expressed inS. frugiperdainsect cells. A low molecular weight chemokine involved in inflammation, hematopoiesis, and immunoregulation. Exhibits chemoattractant activity on monocytes and chemoattractant and proadhesive effects on lymphocytes. MW = 7800.

Specification

• Species: Human
• Source: S.frugiperda
• Tag: Non
• Description: Macrophage Inflammatory Proteins belong to the family of chemotactic cytokines known as chemokines. In humans, there are two major forms, MIP-1a and MIP-1b that are now also named CCL3 and CCL4. Both factors are produced by macrophages after they are stimulated with bacterial endotoxins. MIP-1a and MIP-1b activate human granulocytes (neutrophils, eosinophils and basophils) which can lead to acute neutrophilic inflammation. MIP-1a and MIP-1b induce synthesis and release of other pro-inflammatory cytokines such as interleukin-1 (IL-1), IL-6 and TNF-alpha from fibroblasts and macrophages. CCL3 and CCL4 genes are both located on human chromosome 17.
• Purity: ≥97% by SDS-PAGE.
• Form: Lyophilized from sterile-filtered 30% acetonitrile, 0.1% TFA, 50 µg BSA/µg MIP-1β.
• Biological activity: ED50 = 40-60 ng/ml as measured by its ability to inhibit mouse hematopoietic stem cell proliferation in an in vitro colony assay that detects primitive cells.
• Endotoxin: ≤100 pg/µg MIP-1β.
• Solubility: Sterile PBS containing ≥0.1% HSA or BSA.
• Storage: ≤ -70°C.

Gene Information

• Gene Name: CCL4 chemokine (C-C motif) ligand 4 [ Homo sapiens ]
• Synonyms: CCL4; chemokine (C-C motif) ligand 4; ACT2; ACT-2; G-26; LAG1; MIP1B; SCYA2; SCYA4; MIP1B1; AT744.1; MGC104418; MGC126025; MGC126026; MIP-1-beta; chemokine C-C motif ligand 4; CC chemokine ligand 4; secreted protein G-26; lymphocyte-activation gene 1; small inducible cytokine A4 (homologous to mouse Mip-1b); MIP-1-beta(1-69); HC21; LAG-1; LAG1; G-26 T-lymphocyte-secreted protein; Lymphocyte activation gene 1 protein; Macrophage inflammatory protein 1-beta; PAT 744; Protein H400; Small-inducible cytokine A4; T-cell activation protein 2; chemokine C-C motif ligand 4; ymphocyte-activation gene 1; small inducible cytokine A4 (homologous to mouse Mip-1b)
• Gene ID: 6351
• mRNA Refseq: NM_002984
• Protein Refseq: NP_002975
• MIM: 182284
• UniProt ID: P13236
• Chromosome Location: 17q12
• Pathway: Cytokine-cytokine receptor interaction; Toll-like receptor signaling pathway
• Function: chemokine activity; receptor signaling protein; tyrosine kinase activity