Recombinant Swine Chemokine (C-C motif) Ligand 4

• Cat.No.: CCL4-146S
• Product Overview: Recombinant Swine CCL4 protein was expressed inYeastand purified by using Ion-exchange chromatography, 7.8 kDa (69 aa).

Specification

• Cat. No.: CCL4-146S
• Description: CCL4 is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.
• Source: Yeast.
• Sequences Of Amino Acids: APMGSDPPTS CCFTYTVRKL PRNFVTDYYE TSSLCSQPAV VFQTKKGRQV CANPSDDWVQ EYMDDLELN.
• Formulation/Reconstitution: Lyophilized. Reconstitute with sterile phosphate-buffered saline containing at least 0.1% carrier protein.
• Purity: >95% as visualized by SDS-PAGE analysis.
• Purification: Ion-exchange chromatography.
• Biological Activity: The biological activity of recombinant swine CCL4 was determined in a chemotaxis assay using a Boyden chamber with freshly isolated swine PBMC monocytes using a Percoll gradient enrichment method. Biological activity typically peaks at 10 ng/mL.
• Storage: Stable for up to twelve months from date of receipt at -20°C. Stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. Avoid repeated freeze/thaw cycles.
• Pathways: Chemokine signaling pathway; Cytokine-cytokine receptor interaction; Cytosolic DNA-sensing pathway

Gene Information

• Gene Name: CCL4 chemokine (C-C motif) ligand 4 [ Sus scrofa ]
• Synonyms: CCL4; chemokine (C-C motif) ligand 4; MIP1b; SCY4A; MIP-1BETA; MIP-1-beta; C-C motif chemokine 4; small-inducible cytokine A4; macrophage inflammatory protein 1-beta
• Gene ID: 396668
• mRNA Refseq: NM_213779
• Protein Refseq: NP_998944
• UniProt ID: Q711P4