CCR7
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Official Full Name
chemokine (C-C motif) receptor 7
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Overview
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. -
Synonyms
CCR7; chemokine (C-C motif) receptor 7; CMKBR7, EBI1; C-C chemokine receptor type 7; BLR2; CD197; CDw197; CCR-7; CC-CKR-7; C-C CKR-7; MIP-3 beta receptor; CC chemokine receptor 7; chemokine (C-C) receptor 7; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; lymphocyte-specific G protein-coupled peptide receptor; epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; CMKBR7;
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CCR7 involved in several pathways and played different roles in them. We selected most pathways CCR7 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine receptors bind chemokines | CX3CR1;CCL27;CCR6;CCR9;CCR3;CXCR6;CCL19A.2;CXCL13;CCL35.2 |
| Chemokine signaling pathway | GNG11;GNGT2;Cxcl15;Ccl12;WASL;RHOA;NFKBIA;GNG3;IKBKG |
| Class A/1 (Rhodopsin-like receptors) | AMCF-II;GPR77;FPR-RS4;SSTR1;OPN1SW1;HRH3;CXCR7B;RHOL;NPSR1 |
| Cytokine-cytokine receptor interaction | IL2RB;IL7;IFNL3;CCL26;CD40LG;IFNGR2;IL3RA;TNFSF14;CCL17 |
| G alpha (i) signalling events | CCR9;OPN1LW;NMUR1;RGS21;CCR8;ADRA2B;GPR55A;CXCR6;GPR18 |
| GPCR downstream signaling | RAMP3;UTS2;OR10A5;CRHR2;ADM2;PTH;PYYA;GCGB;LPAR5A |
| GPCR ligand binding | ACKR4;GAL;EDN3;QRFP;PTGDR2;INSL3;GPR132;GRP;OPN5 |
| GPCRs, Class A Rhodopsin-like | SSTR1;GPR45;ACKR4;HRH3;CNR2;GPR3;CCR1;SSTR2;GPR17 |
CCR7 has several biochemical functions, for example, C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR7 itself. We selected most functions CCR7 had, and list some proteins which have the same functions with CCR7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| C-C chemokine receptor activity | CCR10;CCR8;CCR5;CCR9;CCR7;CCR1;CCBP2;GPR75;CCR1L1 |
| C-C motif chemokine 19 receptor activity | |
| C-C motif chemokine 21 receptor activity | |
| G-protein coupled receptor activity | OXGR1;V2RH7;GPR78;RXFP3;TAAR10B;OLFCG1;OLFR482;GPR128;OPRD1B |
| chemokine (C-C motif) ligand 19 binding | |
| chemokine (C-C motif) ligand 21 binding |
CCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR7.
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Q&As (7)
Ask a questionIt directs T cells and dendritic cells to lymph nodes, ensuring proper immune surveillance.
Therapeutic strategies include targeting CCR7 to modulate immune responses in autoimmune diseases and cancer.
CCR7 can facilitate tumor cell invasion and metastasis to lymph nodes.
CCR7 helps form immune synapses for effective T cell activation.
CCR7 guides the migration of various immune cells to lymphoid tissues, aiding in immune responses.
CCR7 is predominantly expressed in T cells, dendritic cells, and various other immune cells.
Genetic alterations in CCR7 have been linked to certain autoimmune diseases and cancers.
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