• Official Full Name

    chemokine (C-C motif) receptor 7

  • Overview

    The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor.
  • Synonyms

    CCR7; chemokine (C-C motif) receptor 7; CMKBR7, EBI1; C-C chemokine receptor type 7; BLR2; CD197; CDw197; CCR-7; CC-CKR-7; C-C CKR-7; MIP-3 beta receptor; CC chemokine receptor 7; chemokine (C-C) receptor 7; Epstein-Barr virus induced gene 1; EBV-induced G protein-coupled receptor 1; EBV-induced G-protein coupled receptor 1; Epstein-Barr virus induced G-protein coupled receptor; lymphocyte-specific G protein-coupled peptide receptor; epstein-Barr virus-induced G-protein coupled receptor 1; EBI1; CMKBR7;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CCR7-853H Active Recombinant Human CCR7 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CCR7-0696H Recombinant Human CCR7 Protein Wheat Germ N/A
Human CCR7-471H Recombinant Human CCR7 Mammalian Cell His
Human CCR7-213H Recombinant Human CCR7 Protein, His-tagged Human Cells His
Human CCR7-4640H Recombinant Human CCR7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CCR7-3045H Recombinant Human CCR7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CCR7-875HFL Recombinant Full Length Human CCR7 Protein, C-Flag-tagged Mammalian cells Flag
Human CCR7-645H Recombinant Human CCR7 Protein, His-tagged E.coli N-His Asn290-Pro378
Human CCR7-527H Recombinant Human CCR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CCR7-1177H Recombinant Human CCR7 protein, His&Myc-tagged E.coli His&Myc 332-378aa
Human CCR7-1077HFL Recombinant Human CCR7 protein, His&Flag-tagged HEK293 His&Flag 1-378 aa
Human CCR7-3021HF Recombinant Full Length Human CCR7 Protein In Vitro Cell Free System 742 amino acids
Human CCR7-527H-B Recombinant Human CCR7 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ccr7-646M Recombinant Mouse Ccr7 Protein, His-tagged E.coli N-His Asn290-Pro378
Mouse Ccr7-906M Recombinant Mouse Ccr7 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Cynomolgus Monkey CCR7-379C Recombinant Cynomolgus CCR7 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CCR7-127C Recombinant Cynomolgus Monkey CCR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CCR7-127C-B Recombinant Cynomolgus Monkey CCR7 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL24918HF Recombinant Full Length Human C-C Chemokine Receptor Type 7(Ccr7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-378)
Mus musculus (Mouse) RFL8205MF Recombinant Full Length Mouse C-C Chemokine Receptor Type 7(Ccr7) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (25-378)
Rhesus Macaque CCR7-710R Recombinant Rhesus monkey CCR7 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CCR7-537R Recombinant Rhesus Macaque CCR7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CCR7-537R-B Recombinant Rhesus Macaque CCR7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish CCR7-5705Z Recombinant Zebrafish CCR7 Mammalian Cell His
Chicken CCR7-4223C Recombinant Chicken CCR7 Mammalian Cell His
Kit-0874 HPRT Assay Kit N/A
Kit-1161 cAMP CCR7 CHO-K1 GPCR Assay Kit N/A
Kit-1050 Factor XIa Activity Assay Kit (Colorimetric) N/A
Kit-1159 CCR7 HEK 293 β-Arrestin GPCR Assay Kit N/A
Kit-1160 CCR7 CHO-K1 β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CCR7 involved in several pathways and played different roles in them. We selected most pathways CCR7 participated on our site, such as Chemokine receptors bind chemokines, Chemokine signaling pathway, Class A/1 (Rhodopsin-like receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine receptors bind chemokinesACKR4;CCR1;AMCF-II;CCRL2;CCR5;CX3CR1;CCL27;CCL35.2;CCR3
Chemokine signaling pathwayELMO1;CCL1;ROCK2;AMCF-II;CXCL13;RLN1;STAT2;GM13306;CCL18
Class A/1 (Rhodopsin-like receptors)RLN3;GPR120;CNR2;FPR-RS3;HCRT;CXCR6;HCAR1-2;RGS1;GPR68
Cytokine-cytokine receptor interactionCCL27B;TNFSF9;PDGFB;IL1R2;CXCL8B.3;CCR5;IL23R;CXCR4;IL25
G alpha (i) signalling eventsCCL19A.2;CCR9;CCR7;PENK;OPN1MW2;ADRA2B;PENKB;LPAR2B;PMCH

CCR7 has several biochemical functions, for example, C-C chemokine receptor activity, C-C motif chemokine 19 receptor activity, C-C motif chemokine 21 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CCR7 itself. We selected most functions CCR7 had, and list some proteins which have the same functions with CCR7. You can find most of the proteins on our site.

Function Related Protein
C-C chemokine receptor activityCCR10;CCR6;CCR8;CCR6A;CCR7;CCR1;CCR3;CCR1L1;CCBP2
C-C motif chemokine 19 receptor activity
C-C motif chemokine 21 receptor activity
G-protein coupled receptor activityAPLNR;OR6K3;VMN1R41;AGTR1B;TAAR12H;ADRB2B;GNRHR4;GPR6;CCR9A
chemokine (C-C motif) ligand 19 binding
chemokine (C-C motif) ligand 21 binding

CCR7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR7 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR7.

Gene Family

Chemokines Cytokines

Research Area

Related articles

Jensen, SS; Hartling, HJ; et al. HIV-Specific ADCC Improves After Antiretroviral Therapy and Correlates With Normalization of the NK Cell Phenotype. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:103-111(2015).
Stepensky, P; Rensing-Ehl, A; et al. Early-onset Evans syndrome, immunodeficiency, and premature immunosenescence associated with tripeptidyl-peptidase II deficiency. BLOOD 125:753-761(2015).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
How does CCR7 contribute to lymphocyte trafficking and homing? 01/23/2022

It directs T cells and dendritic cells to lymph nodes, ensuring proper immune surveillance.

What therapeutic strategies are being explored targeting CCR7 for disease treatment? 12/24/2021

Therapeutic strategies include targeting CCR7 to modulate immune responses in autoimmune diseases and cancer.

How is CCR7 implicated in cancer progression and metastasis? 07/08/2021

CCR7 can facilitate tumor cell invasion and metastasis to lymph nodes.

What role does CCR7 play in the formation of immune synapses? 03/15/2021

CCR7 helps form immune synapses for effective T cell activation.

What is the main function of CCR7 in the immune system? 03/01/2021

CCR7 guides the migration of various immune cells to lymphoid tissues, aiding in immune responses.

In which cells or tissues is CCR7 predominantly expressed? 06/27/2020

CCR7 is predominantly expressed in T cells, dendritic cells, and various other immune cells.

Are there known genetic mutations or alterations in CCR7 associated with specific diseases? 07/14/2019

Genetic alterations in CCR7 have been linked to certain autoimmune diseases and cancers.

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