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Official Full Name CD247 Molecule
Background The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Synonyms CD247; CD247 molecule; T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; Preferred; T-cell surface glycoprotein CD3 zeta chain; OTTHUMP00000032543; OTTHUMP00000032544; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD247-151H Recombinant Human CD247 Protein, His-tagged Human Cells His
    Human CD247-222H Recombinant Human CD247 Protein, His-tagged Human Cells His
    Human CD247-0757H Recombinant Human CD247 Protein, GST-Tagged Wheat Germ GST
    Human CD247-10931H Recombinant Human CD247, GST-tagged E.coli GST
    Human CD247-2726H Recombinant Human CD247 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CD247-27869TH Recombinant Human CD247 Wheat Germ N/A
    Human CD247-7090H Recombinant Human CD247, His-tagged E.coli His
    Human CD247-7091H Recombinant Human CD247 protein, His-tagged E. coli His
    Human CD247-7679HCL Recombinant Human CD247 293 Cell Lysate HEK293 N/A
    Mouse CD247-3062M Recombinant Mouse CD247 Protein Mammalian Cell His
    Mouse Cd247-840M Recombinant Mouse Cd247 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Cynomolgus Monkey CD247-386C Recombinant Cynomolgus CD247 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CD247-730R Recombinant Rhesus monkey CD247 Protein, His-tagged Mammalian Cell His
    Chicken CD247-7091C Recombinant Chicken CD247 Mammalian Cell His
    Zebrafish CD247-5889Z Recombinant Zebrafish CD247 Mammalian Cell His

    cd247 involved in several pathways and played different roles in them. We selected most pathways cd247 participated on our site, such as Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with cd247 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Natural killer cell mediated cytotoxicity NFATC2; IFNGR1; IFNAR1; SOS1; GRB2; RAET1L; IFNAR2; BID; TNFSF10; PRKCB
    T cell receptor signaling pathway DLG1; VAV3; NRAS; CD247; SLA1; IFNG; CD28; OXSR1A; SHB; IL5
    Chagas disease (American trypanosomiasis) CFLAR; C3; PIK3CG; IRAK1; PPP2CB; TLR4; GNAL; MAPK11; TGFBR2; FOS

    cd247 has several biochemical functions, for example, identical protein binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cd247 itself. We selected most functions cd247 had, and list some proteins which have the same functions with cd247. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding ADIPOR2; DNM1; C1QTNF6; COIL; VWA2; CORO1B; MAPK1IP1; CLDN3; SMURF2; ATF3
    protein binding NIP7; GATA1A; PARN; ZNF34; RPP30; CRX; RNF144B; CLIP4; GRAMD3; BAZ1A
    protein homodimerization activity ATIC; CEBPE; SMAGP; AGR2; ACTN1; PON1; TCF4; SNX6; LMLN; GSTA4
    transmembrane signaling receptor activity GABRQ; LGR6; IL11RA; LGR4; CD79A; CD97; TNFRSF8; CD27; SPN; TLR2-2

    cd247 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cd247 here. Most of them are supplied by our site. Hope this information will be useful for your research of cd247.


    Martins, M; Williams, AH; et al. Genetic association of CD247 (CD3 zeta) with SLE in a large-scale multiethnic study. GENES AND IMMUNITY 16:142-150(2015).
    Miyazawa, K; Yoda, K; et al. Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet-induced obesity. MICROBIOLOGY AND IMMUNOLOGY 59:99-103(2015).

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