CD247

  • Official Full Name

    CD247 Molecule

  • Overview

    The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
  • Synonyms

    CD247; CD247 molecule; T3Z; CD3H; CD3Q; CD3Z; TCRZ; CD3-ZETA; Preferred; T-cell surface glycoprotein CD3 zeta chain; OTTHUMP00000032543; OTTHUMP00000032544; CD247 antigen, zeta subunit; T-cell receptor T3 zeta chain; CD3Z antigen, zeta polypeptide (TiT3 complex); T-cell antigen receptor complex, zeta subunit of CD3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Ovis aries (Sheep)
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD247-27869TH Recombinant Human CD247 Wheat Germ N/A
Human CD247-10931H Recombinant Human CD247, GST-tagged E.coli GST
Human CD247-7090H Recombinant Human CD247, His-tagged E.coli His
Human CD247-0757H Recombinant Human CD247 Protein, GST-Tagged Wheat Germ GST
Human CD247-7679HCL Recombinant Human CD247 293 Cell Lysate HEK293 N/A
Human CD247-222H Recombinant Human CD247 Protein, His-tagged Human Cells His
Human CD247-171H Recombinant Human CD247 Protein, C-His-tagged E.coli C-His
Human CD247-2726H Recombinant Human CD247 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD247-1291HFL Recombinant Full Length Human CD247 Protein, C-Flag-tagged Mammalian cells Flag
Human CD247-151H Recombinant Human CD247 Protein, His-tagged Human Cells His
Human CD247-536H Recombinant Human CD247 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD247-0290H Recombinant Human CD247 protein, GST-tagged E.coli GST
Human CD247-0944H Recombinant Human CD247 Protein (Arg52-Arg164), N-GST tagged E.coli N-GST
Human CD247-56HF Recombinant Full Length Human CD247 Protein In Vitro Cell Free System
Human CD247-7091H Recombinant Human CD247 protein, His-tagged E. coli His
Human CD247-3088HF Recombinant Full Length Human CD247 Protein, GST-tagged In Vitro Cell Free System GST
Human CD247-536H-B Recombinant Human CD247 Protein Pre-coupled Magnetic Beads HEK293
Human CD247-5292H Recombinant Human CD247 Protein (Met1-Lys30), C-His tagged Mammalian cells C-His
Mouse CD247-3062M Recombinant Mouse CD247 Protein Mammalian Cell His
Mouse Cd247-840M Recombinant Mouse Cd247 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse CD247-1446M-B Recombinant Mouse CD247 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd247-665M Recombinant Mouse Cd247 Protein, His-tagged E.coli N-His
Mouse CD247-1446M Recombinant Mouse CD247 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CD247-386C Recombinant Cynomolgus CD247 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CD247-134C Recombinant Cynomolgus Monkey CD247 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CD247-134C-B Recombinant Cynomolgus Monkey CD247 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL24008HF Recombinant Full Length Human T-Cell Surface Glycoprotein Cd3 Zeta Chain(Cd247) Protein, His-Tagged E.coli expression system His
Ovis aries (Sheep) RFL36234OF Recombinant Full Length Sheep T-Cell Surface Glycoprotein Cd3 Zeta Chain(Cd247) Protein, His-Tagged E.coli expression system His
Rhesus Macaque CD247-730R Recombinant Rhesus monkey CD247 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CD247-556R-B Recombinant Rhesus Macaque CD247 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CD247-556R Recombinant Rhesus Macaque CD247 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish CD247-5889Z Recombinant Zebrafish CD247 Mammalian Cell His
Chicken CD247-7091C Recombinant Chicken CD247 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD247 Related Articles
  • CD247 Related Research Area

CD247 involved in several pathways and played different roles in them. We selected most pathways CD247 participated on our site, such as Natural killer cell mediated cytotoxicity, T cell receptor signaling pathway, Chagas disease (American trypanosomiasis), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD247 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Natural killer cell mediated cytotoxicityITGAL;TNF;IFNAR2;PPP3R2;TNFRSF10D;IFNA5;Raet1c;KLRD1;FCGR4
T cell receptor signaling pathwayCD8B1;SOS1;DLG1;PTPN6;NFKBIA;SLA1;ZAP70;KRAS;PIK3R1
Chagas disease (American trypanosomiasis)C1QA;CD3G;MAPK12;MAPK3;PPP2CB;IFNGR2;CD247;CASP8;AKT2

CD247 has several biochemical functions, for example, identical protein binding, protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD247 itself. We selected most functions CD247 had, and list some proteins which have the same functions with CD247. You can find most of the proteins on our site.

Function Related Protein
identical protein bindingGOT1;TPCN2;CBX3;FHIT;TYSND1;SH3BP4;BAIAP2;ADIPOR2;TNN
protein bindingABCG8;RAB5C;NDC80;IL6;RAD9B;C1orf51;IL32;CFL1;GRASP
protein homodimerization activityCAT;CADM2A;CSF1;FAM109A;RNF17;TWIST1;TPD52;Pdgfa&Pdgfb;SRGAP2
transmembrane signaling receptor activityGPR113;ENG;NPC1;GPR133;SLAMF1;LILRB3;LGR4;BCAM;Cd79a, Cd79b

CD247 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD247 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD247.

ZAP70

Martins, M; Williams, AH; et al. Genetic association of CD247 (CD3 zeta) with SLE in a large-scale multiethnic study. GENES AND IMMUNITY 16:142-150(2015).
Miyazawa, K; Yoda, K; et al. Influence of orally administered Lactobacillus GG on respiratory immune response in a murine model of diet-induced obesity. MICROBIOLOGY AND IMMUNOLOGY 59:99-103(2015).
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