The protein encoded by this gene is expressed on the surface of T cells. It regulates B cell function by engaging CD40 on the B cell surface. A defect in this gene results in an inability to undergo immunoglobulin class switch and is associated with hyper-IgM syndrome.
CD40LG involved in several pathways and played different roles in them. We selected most pathways CD40LG participated on our site, such as Cytokine-cytokine receptor interaction, NF-kappa B signaling pathway, Cell adhesion molecules (CAMs), which may be useful for your reference. Also, other proteins which involved in the same pathway with CD40LG were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CD40LG has several biochemical functions, for example, CD40 receptor binding, cytokine activity, tumor necrosis factor receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD40LG itself. We selected most functions CD40LG had, and list some proteins which have the same functions with CD40LG. You can find most of the proteins on our site.
CD40LG has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD40LG here. Most of them are supplied by our site. Hope this information will be useful for your research of CD40LG.
Research Area
Related articles
Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
Strickland, FM; Hewagama, A; et al. Diet Influences Expression of Autoimmune-Associated Genes and Disease Severity by Epigenetic Mechanisms in a Transgenic Mouse Model of Lupus. ARTHRITIS AND RHEUMATISM 65:1872-1881(2013).
The reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.
01/01/2022
Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.
11/16/2020
Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.
Are there any ongoing clinical trials targeting CD40LG for autoimmune diseases?
11/01/2022
Yes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.
Can CD40LG be a potential target for the treatment of infectious diseases?
02/27/2021
Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.
How does the interaction between CD40LG and its receptor CD40 influence antibody production?
11/20/2020
The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.
How is CD40LG involved in the regulation of inflammatory responses?
08/26/2020
CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.
In what ways is CD40LG being explored for its potential in vaccine development?
04/20/2020
CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.
