Recombinant Rabbit CD40LG Protein

• Cat.No.: CD40LG-02R
• Product Overview: The Rabbit CD40LG recombinant protein without tag was produced in yeast and therefore does not have endotoxin, is naturally folded, and post-translationally modified.

Specification

• Description: CD40 Ligand (CD40LG) is a transmembrane protein that is a member of the TNF superfamily. In addition to existing in a membrane bound form, CD40LG can also be released as a soluble molecule (sCD40LG), which has been shown to have biological functions.
  CD40 interacts with CD40 ligand (aka CD40LG, TNFSF5 or CD154), which is predominantly expressed on activated CD4+ T-cells. CD40LG is transiently expressed on activated T-cells and plays a crucial role in B-cell function. Activated T-cells expressing CD40LG can also interact with CD40 on endothelial cells to induce production of inflammatory cytokines. The transient expression of CD40LG allows T-cells to stimulate selected CD40-bearing cells to participate in the immune response. Increased levels of sCD40LG have been measured in patients with SLE, RA, inflammatory bowel diseases, systemic sclerosis, and Sjogren's syndrome. In culture, canine sCD40LG was shown to promote the maturation and activation of canine monocyte derived Dendritic cells.
• Source: Yeast
• Species: Rabbit
• Molecular Mass: 16.2 kDa
• AA Sequence: MQKGDQDPQIAAHLISEASSKSSSV LQWAKKGYYTMSNTLVTLENGKQLK VKRQGFYYIYAQVTFCSNQEPSSQA PFIASLCLKSSGGSERILLRAANAR SSSKTCEQQSIHLGGVFELQADASV FVNVTDASQVNHGTGFTSFGLLKL(149)
• Applications: The Rabbit CD40LG endotoxin-free recombinant protein can be used in cell culture, as an ELISA Standard, and as a Western Blot Control.

Gene Information

• Gene Name: CD40LG CD40 ligand [ Oryctolagus cuniculus (rabbit) ]
• Official Symbol: CD40LG
• Synonyms: CD40LG; CD40 ligand; TNLG8B; CD40 ligand; tumor necrosis factor ligand 8B
• Gene ID: 100358388
• mRNA Refseq: NM_001256781
• Protein Refseq: NP_001243710
• UniProt ID: G1SKP7

Reviews

10/17/2022

The reliable performance of the CD40LG protein in ELISA and its compatibility with protein electron microscopy structure analysis make it an excellent choice for a wide range of research studies.

01/01/2022

Its reliable and accurate performance ensures dependable results, contributing to the advancement of scientific knowledge in various fields of study.

11/16/2020

Their knowledgeable and responsive team assists in troubleshooting and finding solutions to any experimental challenges that may arise.

Q&As

Are there any ongoing clinical trials targeting CD40LG for autoimmune diseases?

Yes, there are clinical trials investigating the modulation of CD40LG in autoimmune diseases, exploring its potential role in regulating immune responses that contribute to autoimmunity.

Can CD40LG be a potential target for the treatment of infectious diseases?

Yes, research suggests that CD40LG modulation might be a viable strategy in the development of treatments for infectious diseases by enhancing immune responses.

How does the interaction between CD40LG and its receptor CD40 influence antibody production?

The interaction between CD40LG and CD40 is crucial for the activation of B cells, leading to the production of antibodies and the development of an effective immune response.

How is CD40LG involved in the regulation of inflammatory responses?

CD40LG is involved in modulating inflammatory responses by influencing the activation and function of immune cells, contributing to the regulation of the immune system.

In what ways is CD40LG being explored for its potential in vaccine development?

CD40LG is being investigated as an adjuvant in vaccine development, aiming to enhance the immune response and improve the efficacy of vaccines against various diseases.