CD48

  • Official Full Name

    CD48 CD48 molecule

  • Overview

    CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for 2B4. CD482B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk.The absence of functional 2B4 CD48 interactions impairs NK cell cytotoxic response and IFN-release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by a 2B4CD48-dependent mechanism.
  • Synonyms

    CD48; CD48 molecule; BCM1, CD48 antigen (B cell membrane protein) , CD48 molecule; CD48 antigen; BLAST; hCD48; mCD48; SLAMF2; TCT.1; BCM1 surface antigen; leukocyte antigen MEM-102; B-lymphocyte activation marker BLAST-1; CD48 antigen (B-cell membrane protein); BCM1; BLAST1; MEM-102;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Antibody
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • CHO cells
  • E. coli
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Rabbit
  • Wheat Germ
  • Yeast
  • C
  • Fc
  • hFc
  • His
  • Avi
  • Fc|His
  • His(C
  • ter)
  • GST
  • His (Fc)
  • His|T7
  • human|IgG1|Fc
  • Mouse|IgG2a|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD48-680H Active Recombinant Human CD48, Fc-tagged, Biotinylated Human Cell Fc
Human CD48-3255H Active Recombinant Human CD48 protein(Met1-Ser220), His&Avi-tagged, Biotinylated HEK293 C-His&Avi
Human CD48-051H Active Recombinant Human CD48 protein, His/Avi-tagged, Biotinylated CHO cells His/Avi
Human CD48-10960H Recombinant Human CD48 Protein, GST-tagged E. coli GST
Human CD48-0828H Recombinant Human CD48 Protein, GST-Tagged Wheat Germ GST
Human CD48-234H Recombinant Human CD48 protein, Fc-tagged HEK293 human/IgG1/Fc
Human CD48-654H Recombinant Human CD48 protein, His-tagged HEK293 His
Human CD48-1871H Recombinant Human CD48 protein, His & T7-tagged E.coli His/T7
Human CD48-719H Recombinant Human CD48 Protein CHO N/A
Human CD48-838H Recombinant Human CD48 Protein, Fc/His-tagged HEK293 Fc/His
Human CD48-26635TH Recombinant Human CD48 Wheat Germ N/A
Human CD48-252H Active Recombinant Human CD48 protein, hFc-tagged HEK293 hFc
Human CD48-3044HCL Recombinant Human CD48 cell lysate Human Cell N/A
Human CD48-646H Recombinant Human CD48 Protein HEK293
Human CD48-357H Recombinant Human CD48 protein, Mouse IgG2a Fc-tagged, low endotoxin HEK293 Mouse/IgG2a/Fc
Human CD48-654HAF488 Recombinant Human CD48 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Human CD48-5369H Recombinant Human CD48 protein, hFc-tagged Yeast hFc
Human CD48-200H Recombinant Human CD48 Protein, C-His-tagged E.coli C-His
Human CD48-252HF Recombinant Human CD48 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Human CD48-252HAF647 Recombinant Human CD48 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Human CD48-63HF Recombinant Full Length Human CD48 Protein In Vitro Cell Free System
Human CD48-654HAF647 Recombinant Human CD48 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Human CD48-654HF Recombinant Human CD48 Protein, His-tagged, FITC conjugated HEK293 His
Human CD48-2998HF Recombinant Full Length Human CD48 Protein, GST-tagged In Vitro Cell Free System GST
Human CD48-34H Recombinant Human CD48 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter)
Human CD48-2638H Active Recombinant Human CD48 protein, hFc&His-tagged HEK293 hFc&His
Human CD48-509H Recombinant Human CD48 Protein (Gln27-Ser220), C-hFc-tagged HEK293 C-hFc
Human CD48-0263H Active Recombinant Human CD48 protein, hFc&Avi-tagged, Biotinylated HEK293 hFc&Avi
Human CD48-35H Recombinant Human CD48 Protein (ECD), His-tagged(C-ter) HEK293 His(C-ter)
Human CD48-1416H Recombinant Human CD48 Protein (Gln27-Ser220), N-His tagged E.coli N-His
Human CD48-2179H Active Recombinant Human CD48 protein, His-tagged HEK293 His
Human CD48-5356H Recombinant Human CD48 Protein (Met1-Ser220), C-His tagged Mammalian cells C-His
Human CAB11502RH Rabbit Anti-Human CD48 Molecule Monoclonal Antibody Rabbit N/A
Human CD48-5357H Recombinant Human CD48 Protein (Met1-Ser220), C-Fc tagged Mammalian cells C-Fc
Human CD48-252HAF555 Recombinant Human CD48 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Human CD48-2042H Recombinant Human CD48 Protein, Fc/His-tagged HEK293 Fc/His
Human CD48-654HAF555 Recombinant Human CD48 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Human CD48-204HG Active GMP Recombinant Human CD48 protein HEK293
Human CD48-151H Recombinant Human CD48 Protein, His-tagged Human Cells His
Human CD48-252HAF488 Recombinant Human CD48 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Mouse CD48-867M Active Recombinant Mouse CD48 Protein, His-tagged HEK293 His
Mouse Cd48-459M Active Recombinant Mouse Cd48, His-tagged Mammalian cells His
Mouse CD48-867MAF555 Active Recombinant Mouse CD48 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Mouse CD48-867MAF488 Active Recombinant Mouse CD48 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Mouse CD48-867MF Active Recombinant Mouse CD48 Protein, His-tagged, FITC conjugated HEK293 His
Mouse CD48-867MAF647 Active Recombinant Mouse CD48 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Mouse Cd48-1872M Recombinant Mouse Cd48 protein, His & T7-tagged E.coli His/T7
Mouse CD48-720M Recombinant Mouse CD48 Protein CHO N/A
Mouse Cd48-3293M Recombinant Mouse CD48 Antigen, His-tagged Human Cell His
Mouse Cd48-486M Recombinant Mouse Cd48, Fc-tagged Human Cell Fc
Mouse CD48-2468MCL Recombinant Mouse CD48 cell lysate Human Cell N/A
Mouse CD48-867MB Recombinant Mouse CD48 protein, His-tagged, Biotinylated HEK293 His
Mouse Cd48-486MAF488 Recombinant Mouse Cd48 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Mouse Cd48-486MAF555 Recombinant Mouse Cd48 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Mouse Cd48-486MAF647 Recombinant Mouse Cd48 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Mouse Cd48-1464M Recombinant Mouse Cd48 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cd48-486MF Recombinant Mouse Cd48 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Mouse Cd48-1464M-B Recombinant Mouse Cd48 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cd48-6807M Recombinant Mouse Cd48 Protein (Phe23-Arg216), C-His tagged Mammalian cells C-His
Rat Cd48-8763R Recombinant Rat Cd48 protein, His-tagged HEK293 His
Rat Cd48-8762R Recombinant Rat Cd48 protein(Met1-Arg216), hFc-tagged HEK293 C-hFc
Rat CD48-1256R Recombinant Rat CD48 Protein Mammalian Cell His
Rat Cd48-1873R Recombinant Rat Cd48 protein, His & T7-tagged E.coli His/T7
Rat CD48-1258RCL Recombinant Rat CD48 cell lysate Human Cell N/A
Rat CD48-914R-B Recombinant Rat CD48 Protein Pre-coupled Magnetic Beads HEK293
Rat Cd48-8762RAF555 Recombinant Rat Cd48 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc
Rat CD48-914R Recombinant Rat CD48 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cd48-8763RAF488 Recombinant Rat Cd48 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His
Rat Cd48-8762RAF488 Recombinant Rat Cd48 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc
Rat Cd48-8763RAF555 Recombinant Rat Cd48 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His
Rat Cd48-8762RAF647 Recombinant Rat Cd48 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc
Rat Cd48-8763RAF647 Recombinant Rat Cd48 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His
Rat Cd48-8762RF Recombinant Rat Cd48 Protein, Fc-tagged, FITC conjugated HEK293 Fc
Rat Cd48-8763RF Recombinant Rat Cd48 Protein, His-tagged, FITC conjugated HEK293 His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CD48 Related Articles
  • CD48 Related Gene Family
  • CD48 Related Research Area

CD48 involved in several pathways and played different roles in them. We selected most pathways CD48 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD48 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Natural killer cell mediated cytotoxicityRAET1E;IFNA8;KIR2DS2;IFNA5;KLRC4-KLRK1;NRAS;PRF1;CD48;FCGR3A

CD48 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD48 itself. We selected most functions CD48 had, and list some proteins which have the same functions with CD48. You can find most of the proteins on our site.

Function Related Protein
protein bindingDCTN1;PPIA;RPS6;PHAX;SLC4A1AP;UBE2L6;MICU1;PLXNC1;HMG20B

CD48 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD48 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD48.

CD244; EEF1D; yapA; BXDC2

Meazza, R; Tuberosa, C; et al. XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1526-1534(2014).
Hashmi, FK; Cail, R; et al. Adaptation of WM-68 Hybridoma Cell-line in Minimal Serum and Serum Free Culture Conditions. PAKISTAN JOURNAL OF ZOOLOGY 46:355-362(2014).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
Could the expression level of CD48 protein be modulated to treat disease? 11/02/2022

There is currently no treatment that directly regulates CD48 protein expression levels. However, by regulating the function of the immune system, the expression level of CD48 protein can be indirectly affected to treat some diseases.

How does the expression level of CD48 protein relate to the prognosis of tumors? 10/06/2022

Expression level of CD48 protein is associated with the prognosis of certain tumors. In some cancers, high levels of CD48 protein expression may predict a poor prognosis.

How does CD48 protein relate to the immune system? 04/16/2022

CD48 protein is an important molecule in the immune system that is involved in the activation and differentiation of lymphocytes and phagocytes, as well as inflammation and tissue repair. Its expression levels may affect the function of the immune system.

Does the level of CD48 protein expression correlate with vaccine efficacy? 06/09/2020

Studies have shown that the expression level of CD48 protein may affect the effectiveness of vaccination. In some cases, high levels of CD48 protein expression may suppress the immune response, thus affecting the effectiveness of vaccination.

Can CD48 protein be used as a biomarker for tumors? 03/26/2020

Yes, the CD48 protein can be used as a biomarker for some tumors. Studies have shown that in some cancers, high levels of CD48 protein expression may predict tumor growth and metastasis.

How does the expression level of CD48 protein relate to the occurrence and progression of the disease? 12/02/2019

Studies have shown that the expression level of CD48 protein may be associated with the occurrence and progression of certain diseases. For example, in some cancers, the expression level of the CD48 protein may affect the growth and metastasis of the tumor.

Customer Reviews (3)

Write a review
Reviews
09/25/2022

    The anti-interference ability in Western blot is very strong, which can effectively resist the influence of endogenous interference factors.

    05/14/2021

      High safety, high expression level, ideal for laboratory and practical applications.

      02/18/2021

        Low preparation cost, high cost performance, saving funds, very suitable for our research.

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