CD48 is a glycosylphosphatidylinositol-anchored protein belonging to the CD2 subfamily. It is expressed mainly on hematopoietic cells and exists in both membrane-associated and soluble forms. It is a low-affinity ligand for CD2 and is implicated as an important costimulatory molecule in lymphocyte activation. Indeed, CD48 has been described as facilitating cell adhesion, innate responses to bacterial infection, and graft rejection. In addition, CD48 is a high-affinity ligand for 2B4. CD482B4 interactions can modulate T cell, B cell, and natural killer (NK) cell functions and cross-talk.The absence of functional 2B4 CD48 interactions impairs NK cell cytotoxic response and IFN-release on tumor target exposure. Furthermore, activated NK cells significantly increase the CD3-dependent proliferation of CD8+ and CD4+ T cells by a 2B4CD48-dependent mechanism.
CD48 involved in several pathways and played different roles in them. We selected most pathways CD48 participated on our site, such as Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD48 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
CD48 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD48 itself. We selected most functions CD48 had, and list some proteins which have the same functions with CD48. You can find most of the proteins on our site.
CD48 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD48 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD48.
CD244; EEF1D; yapA; BXDC2
Meazza, R; Tuberosa, C; et al. XLP1 inhibitory effect by 2B4 does not affect DNAM-1 and NKG2D activating pathways in NK cells. EUROPEAN JOURNAL OF IMMUNOLOGY 44:1526-1534(2014).
Hashmi, FK; Cail, R; et al. Adaptation of WM-68 Hybridoma Cell-line in Minimal Serum and Serum Free Culture Conditions. PAKISTAN JOURNAL OF ZOOLOGY 46:355-362(2014).
Could the expression level of CD48 protein be modulated to treat disease?
There is currently no treatment that directly regulates CD48 protein expression levels. However, by regulating the function of the immune system, the expression level of CD48 protein can be indirectly affected to treat some diseases.
How does the expression level of CD48 protein relate to the prognosis of tumors?
Expression level of CD48 protein is associated with the prognosis of certain tumors. In some cancers, high levels of CD48 protein expression may predict a poor prognosis.
How does CD48 protein relate to the immune system?
CD48 protein is an important molecule in the immune system that is involved in the activation and differentiation of lymphocytes and phagocytes, as well as inflammation and tissue repair. Its expression levels may affect the function of the immune system.
Does the level of CD48 protein expression correlate with vaccine efficacy?
Studies have shown that the expression level of CD48 protein may affect the effectiveness of vaccination. In some cases, high levels of CD48 protein expression may suppress the immune response, thus affecting the effectiveness of vaccination.
Can CD48 protein be used as a biomarker for tumors?
Yes, the CD48 protein can be used as a biomarker for some tumors. Studies have shown that in some cancers, high levels of CD48 protein expression may predict tumor growth and metastasis.
How does the expression level of CD48 protein relate to the occurrence and progression of the disease?
Studies have shown that the expression level of CD48 protein may be associated with the occurrence and progression of certain diseases. For example, in some cancers, the expression level of the CD48 protein may affect the growth and metastasis of the tumor.