CD69

  • Official Full Name

    CD69 antigen

  • Overview

    CD69 is a phosphorylated disulphide-linked dimmer composed of two chains of 27 kDa and 33 kDa, and also known as activation inducer molecule (AIM). CD69 is the earliest inducible surface antigen expressed on lymphocytes after T and B cell activation. CD69 is absent from resting lymphocytes (Sanchez-Madrid, 1995). Other cells, including epidermal Langerhans cells, natural killer (NK) cells, eosinophils, neutrophils, and platelets may also express CD69 (Poggi, 2002). In vitro studies have demonstrated a transient expression of CD69 on activated T cells. After activation, surface expression can be detected within 2-4 hours, reaching a maximum after 18-24 hours followed by a gradual decrease (Hara, 1986). CD69 is thus detectable prior to other activation antigens like CD25 and CD71. CD69 is believed to be involved in signal transduction, since cross-linking with anti-CD69 induces activation (Testi, 1989).
  • Synonyms

    CD69; CD69 antigen; early activation antigen CD69; Very Early Activation Antigen; AIM; VEA; AI452015; 5830438K24Rik;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Rat
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CD69-0844H Recombinant Human CD69 Protein, GST-Tagged Wheat Germ GST
Human CD69-27505TH Recombinant Human CD69 Wheat Germ N/A 110 amino acids
Human CD69-2225H Recombinant Human CD69 protein, His-tagged HEK293 His Ser62-Lys199
Human CD69-142H Recombinant Human CD69 Mammalian Cell His
Human CD69-34H Recombinant Human CD69 Protein, His-tagged Insect Cell His
Human CD69-2573HCL Recombinant Human CD69 cell lysate Human Cell N/A
Human CD69-151H Recombinant Human CD69 Protein, His-tagged Human Cells His
Human CD69-2032H Recombinant Human CD69 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CD69-3101H Recombinant Human CD69 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CD69-2636H Recombinant Human CD69 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CD69-694H Recombinant Human CD69 Protein, His-tagged E.coli N-His Ser62-Lys199
Human CD69-3028HF Recombinant Full Length Human CD69 Protein, GST-tagged In Vitro Cell Free System GST 199 amino acids
Human CD69-1101H Recombinant Human CD69 Protein (Ser62-Lys199), His tagged E.coli His Ser62-Lys199
Human CD69-2636H-B Recombinant Human CD69 Protein Pre-coupled Magnetic Beads HEK293
Human CD69-203M CD69 protein-coupled magnetic MicroBeads
Human CD69-205H Recombinant Human CD69 Protein, C-His-tagged E.coli C-His
Human CD69-5364H Recombinant Human CD69 Protein (Ser62-Lys199), C-His tagged Mammalian cells C-His Ser62-Lys199
Human CD69-168H Recombinant Human CD69 Protein, His-tagged HEK293 His 199
Mouse Cd69-903M Recombinant Mouse Cd69 Protein, His-tagged HEK293 His
Mouse Cd69-902M Recombinant Mouse Cd69 Protein, Fc-tagged HEK293 Fc
Mouse Cd69-846M Recombinant Mouse Cd69 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Cd69-5811R Recombinant Rat Cd69 protein, His-tagged E.coli His Cys43~Glu187
Rat Cd69-695R Recombinant Rat Cd69 Protein, His-tagged E.coli N-His Ser62-Leu199
Rhesus monkey CD69-1801R Recombinant Rhesus Monkey CD69 Protein HEK293 N/A
Rhesus monkey CD69-1802R Recombinant Rhesus Monkey CD69 Protein, hIgG1-tagged HEK293 hIgG1
Rhesus monkey CD69-1803R Recombinant Rhesus Monkey CD69 Protein, hIgG4-tagged HEK293 hIgG4
Mus musculus (Mouse) RFL27501MF Recombinant Full Length Mouse Early Activation Antigen Cd69(Cd69) Protein, His-Tagged E.coli expression system His Full Length (1-199)
Chicken CD69-3609C Recombinant Chicken CD69 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CD69 involved in several pathways and played different roles in them. We selected most pathways CD69 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CD69 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

CD69 has several biochemical functions, for example, calcium ion binding, carbohydrate binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD69 itself. We selected most functions CD69 had, and list some proteins which have the same functions with CD69. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingLDLRA;RAB11FIP4A;DSG2.1;SCUBE1;ITSN2A;ANXA13;ANXA5A;ANXA3A;TBC1D8B
carbohydrate bindingLMAN1L;CLEC4A2;CANX;MAN2A1;CD69;SIGLEC6;GRIFIN;CLEC4E;GALNT12
protein bindingCPSF6;C15orf23;BRAF;FOXD3;THEMIS;PTGIS;CARKD;NR3C2;C22orf28
transmembrane signaling receptor activityNRXN3;GHRHR2;CLEC4A;ERBB2;HIST2H3C2;CLDN3;IL4R.1;EGFR;FZD3B

CD69 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD69 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD69.

TMEM190; secA2

Research Area

Related articles

Tomescu, C; Seaton, KE; et al. Innate Activation of MDC and NK Cells in High-Risk HIV-1-Exposed Seronegative IV-Drug Users Who Share Needles When Compared With Low-Risk Nonsharing IV-Drug User Controls. JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES 68:264-273(2015).
Suzuki, S; Konnai, S; et al. Increased expression of the regulatory T cell-associated marker CTLA-4 in bovine leukemia virus infection. VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY 163:115-124(2015).
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