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Official Full Name C-type lectin domain family 7, member A
Background This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded;glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a;cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition;receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this;way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms,;have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the;natural killer gene complex region.
Synonyms CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; Beta GR; BGR; C type calcium dependent carbohydrate recognition domain lectin superfamily member 12; C type lectin domain family 7 member a; CLEC7A protein; Clecsf12; DECTIN 1 receptor; Dectin1; Dendritic cell associated C type lectin 1; Lectin like receptor 1; Putative transmembrane protein dectin 1; dectin-1; OTTHUMP00000164964; OTTHUMP00000164965; OTTHUMP00000164966; OTTHUMP00000233744; OTTHUMP00000233745; OTTHUMP00000233746; OTTHUMP00000233748; OTTHUMP00000233749; beta-glucan receptor; lectin-like receptor 1; DC-associat; CANDF4
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Rhesus monkey
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • mFc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CLEC7A-001HCL Recombinant Human CLEC7A cell lysate Human Cell N/A
    Human CLEC7A-11322H Recombinant Human CLEC7A, His-tagged E.coli His
    Human CLEC7A-1473H Recombinant Human CLEC7A Protein, GST-tagged Wheat Germ GST
    Human CLEC7A-260H Recombinant Human CLEC7A Human Cell N/A
    Human CLEC7A-261H Recombinant Human CLEC7A, Fc-tagged Human Cell Fc
    Human CLEC7A-262H Recombinant Human CLEC7A protein (Thr66-Met201), mFc-tagged HEK293 mFc
    Human CLEC7A-746H Recombinant Human CLEC7A Protein, His-tagged Mammalian cells His
    Human CLEC7A-760HCL Recombinant Human CLEC7A cell lysate Human Cell N/A
    Mouse Clec7a-2204M Recombinant Mouse Clec7a, His tagged Human Cell His
    Mouse CLEC7A-2455MCL Recombinant Mouse CLEC7A cell lysate Human Cell N/A
    Rhesus monkey CLEC7A-1793R Recombinant Rhesus Monkey CLEC7A Protein HEK293 N/A
    Rhesus Macaque CLEC7A-907R Recombinant Rhesus monkey CLEC7A Protein, His-tagged Mammalian Cell His

    clec7a involved in several pathways and played different roles in them. We selected most pathways clec7a participated on our site, such as Phagosome, Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with clec7a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Phagosome THBS3; ATP6V1A; ATP6V0B; THBS4B; FCGR2B; TLR2-1; RAC1; ATP6V0C; ATP6V1C1; ATP6V1E2
    Tuberculosis MAPK10; CAMP; LBP; RAB7A; IFNA8; PPP3CC; PPP3CB; IFNB1; RAB5B; CD14

    clec7a has several biochemical functions, for example, (1->3)-beta-D-glucan binding, (1->3)-beta-D-glucan receptor activity, MHC protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by clec7a itself. We selected most functions clec7a had, and list some proteins which have the same functions with clec7a. You can find most of the proteins on our site.

    Function Related Protein
    (1->3)-beta-D-glucan binding PTX3; CD209B; CLEC7A
    (1->3)-beta-D-glucan receptor activity CLEC7A
    MHC protein binding CLEC7A; MARCH1; TRGV3
    carbohydrate binding CLEC4F; CHIA; PYGM; LGALS2B; CLEC1B; ZG16; PRG3; GALNT14; LGALS7B; FBXO6
    metal ion binding ATP2B3A; ZNF683; CYP27C1; NUDT10; CYP2AA2; LIG4; ZKSCAN1; ZNF215; LMTK3; DTD1
    opsonin binding ITGAM; CLEC7A; Itgam&Itgb2
    protein binding FAM151B; PMM2; GRIK3; HSPA6; CAMTA2; HTR6; PDLIM3; BATF; TCOF1; PNKP
    signaling pattern recognition receptor activity TLR2; COLEC12; MARCO; DMBT1; CLEC7A; FCN1; TRIM5

    clec7a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with clec7a here. Most of them are supplied by our site. Hope this information will be useful for your research of clec7a.


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