Recombinant Human CLEC7A Protein, His-tagged

• Cat.No.: CLEC7A-131H
• Product Overview: Recombinant Human CLEC7A Protein with His tag was expressed in E. coli.

Specification

• Description: Dectin-1 is a C-type lectin receptor expressed by macrophages, monocytes, dendrtic cells, neutrophils, and a subset of γδ T cells. Dectin-1 is a glycoprotein with eight different isoforms, generated through alternative splicing. It plays an important role in anti-fungal immunity by acting as a pattern recognition receptor for β-glucans found on the cell wall of fungi and some bacteria. Dectin-1 is composed of a short amino-terminal cytoplasmic domain containing an ITAM-like motif, a transmembrane domain, and an extracellular carboxy-terminal C-type lectin domain. Dectin-1 recognizes β-glucans through its C-type lectin domain and transduces signals through its ITAM-like motif by recruiting and activating Syk. Dendritic cells activated through Dectin-1 promote differentiation of Th17 cells by producing IL-6 and IL-23.
• Source: E. coli
• Species: Human
• Tag: His
• Molecular Mass: ~21 kDa
• AA Sequence: TMAIWRSNSGSNTLENGYFLSRNKE NHSQPTQSSLEDSVTPTKAVKTTGV LSSPCPPNWIIYEKSCYLFSMSLNS WDGSKRQCWQLGSNLLKIDSSNELG FIVKQVSSQPDNSFWIGLSRPQTEV PWLWEDGSTFSSNLFQIRTTATQEN PSPNCVWIHVSVIYDQLCSVPSYSI CEKKFSM
• Purity: Transferred into competent cells and the supernatant was purified by NI column affinity chromatography and the purity is > 85% (by SDS-PAGE).
• Notes: For research use only, not for use in diagnostic procedure.
• Storage: Store at 4 centigrade short term. Aliquot and store at -20 centigrade long term. Avoid freeze-thaw cycles.
• Concentration: ≥0.5 mg/mL
• Storage Buffer: PBS, 4M Urea, pH7.4

Gene Information

• Gene Name: CLEC7A C-type lectin domain family 7, member A [ Homo sapiens (human) ]
• Official Symbol: CLEC7A
• Synonyms: CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; BGR; CANDF4; DECTIN1; CLECSF12
• Gene ID: 64581
• mRNA Refseq: NM_022570
• Protein Refseq: NP_072092
• MIM: 606264
• UniProt ID: Q9BXN2