Recombinant Human CLEC7A

• Cat.No.: CLEC7A-260H
• Product Overview: A DNA sequence encoding the extracellular domain of the human Dectin1 (NP_072092.2) (Thr66-Met201) was expressed.

Specification

• Species: Human
• Source: Human Cells
• Tag: Non
• Protein Length: Thr66-Met201
• Description: C-type lectin domain family 7 member A, also known as Dendritic cellassociated C-type lectin 1, Dectin-1, Beta-glucan receptor, C-type lectin superfamily member 12, BGR, CLECSF12, and CLEC7A, is a single-pass type I I membrane protein which contains one C-type lectin domain. CLEC7A (Dectin-1) belongs to the large family of pattern recognition receptors (PRRs) which recognize conserved pathogen-associated molecular patterns (PAMPs). CLEC7A (Dectin-1) is highly expressed in peripheral blood leukocytes and dendritic cells. It is also detected in spleen, bone marrow, lung, muscle, stomach and placenta. CLEC7A (Dectin-1) is a pattern-recognition receptor that predominantly recognizes beta-glucans from fungi, plants and bacteria. CLEC7A (Dectin-1) is implicated in immunological defenses against pathogens that have betaglucans. CLEC7A (Dectin-1) was identified as the most important receptor for beta-glucan. Recognition of beta-glucan by CLEC7A (Dectin-1) triggers effective immune response, including phagocytosis and proinflammatory factor production, to eliminate infecting fungi. CLEC7A (Dectin-1) is also involved in the adaptive immune response as well as autoimmune diseases and immune tolerance. CLEC7A (Dectin-1) is a small C-type lectin receptor for fungal cell wall beta-glucan. Its homologues in some species, including mouse and human. The sequence of mouse CLEC7A (Dectin-1) is found to be highly homologous to that of the rat. It possesses essential motifs for the recognition of betaglucan and signal transduction. Mouse CLEC7A (Dectin-1) plays essential roles in immune responses against fungi.
• Form: Lyophilized from sterile PBS, pH7.4.
• Molecular Mass: The recombinant human Dectin1 comprises 136 amino acids and has a predicted molecular mass of 15.5 kDa. The apparent molecular mass of the monomer is approximately 15 kDa in SDS-PAGE under reducing conditions.
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >90 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: CLEC7A C-type lectin domain family 7, member A [ Homo sapiens ]
• Official Symbol: CLEC7A
• Synonyms: CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12 , CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; BGR; CANDF4; DECTIN1; CLECSF12
• Gene ID: 64581
• mRNA Refseq: NM_022570
• Protein Refseq: NP_072092
• MIM: 606264
• UniProt ID: Q9BXN2
• Chromosome Location: 12p13.2-p12.3
• Pathway: Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem
• Function: (1->3)-beta-D-glucan binding; MHC protein binding; binding; metal ion binding; opsonin binding; pattern recognition receptor activity; sugar binding; sugar binding