Recombinant Human CLEC7A Protein (T66-M247), His tagged
Cat.No. : | CLEC7A-0624H |
Product Overview : | Recombinant Human 6His-MBP-TEV-Dectin-1(T66-M247 end)-Flag Protein was expressed in E. coli. |
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Description : | Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein length : | T66-M247 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | CLEC7A C-type lectin domain family 7, member A [ Homo sapiens (human) ] |
Official Symbol : | CLEC7A |
Synonyms : | CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12, CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; BGR; CANDF4; DECTIN1; CLECSF12; |
Gene ID : | 64581 |
mRNA Refseq : | NM_022570 |
Protein Refseq : | NP_072092 |
MIM : | 606264 |
UniProt ID : | Q9BXN2 |
Products Types
◆ Recombinant Protein | ||
CLEC7A-2686H | Recombinant Human CLEC7A Protein, His (Fc)-Avi-tagged | +Inquiry |
CLEC7A-130H | Recombinant Human CLEC7A Protein, C-His-tagged | +Inquiry |
CLEC7A-1697H | Recombinant Human CLEC7A protein, hFc-tagged | +Inquiry |
CLEC7A-732R | Recombinant Rhesus Macaque CLEC7A Protein, His (Fc)-Avi-tagged | +Inquiry |
CLEC7A-131H | Recombinant Human CLEC7A Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CLEC7A-760HCL | Recombinant Human CLEC7A cell lysate | +Inquiry |
CLEC7A-001HCL | Recombinant Human CLEC7A cell lysate | +Inquiry |
CLEC7A-2455MCL | Recombinant Mouse CLEC7A cell lysate | +Inquiry |
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