Recombinant Human CLEC7A Protein (T66-M247), His tagged
Cat.No. : | CLEC7A-0624H |
Product Overview : | Recombinant Human 6His-MBP-TEV-Dectin-1(T66-M247 end)-Flag Protein was expressed in E. coli. |
- Specification
- Gene Information
- Related Products
Description : | Lectin that functions as pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans. |
Source : | E. coli |
Species : | Human |
Tag : | His |
Form : | Liquid |
Protein Length : | T66-M247 |
Endotoxin : | < 0.01 EU per μg of the protein |
Purity : | 90% |
Stability : | Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. |
Storage : | Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles. |
Storage Buffer : | Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol |
Shipping : | It is shipped out with blue ice. |
Gene Name : | CLEC7A C-type lectin domain family 7, member A [ Homo sapiens (human) ] |
Official Symbol : | CLEC7A |
Synonyms : | CLEC7A; C-type lectin domain family 7, member A; C type (calcium dependent, carbohydrate recognition domain) lectin, superfamily member 12, CLECSF12; C-type lectin domain family 7 member A; dectin 1; hDectin 1; dectin-1; beta-glucan receptor; lectin-like receptor 1; DC-associated C-type lectin 1; C-type lectin superfamily member 12; dendritic cell-associated C-type lectin 1; dendritic cell-associated C-type lectin-1; C-type (calcium dependent, carbohydrate-recognition domain) lectin, superfamily member 12; BGR; CANDF4; DECTIN1; CLECSF12; |
Gene ID : | 64581 |
mRNA Refseq : | NM_022570 |
Protein Refseq : | NP_072092 |
MIM : | 606264 |
UniProt ID : | Q9BXN2 |
Products Types
◆ Recombinant Protein | ||
CLEC7A-2686H | Recombinant Human CLEC7A Protein, His (Fc)-Avi-tagged | +Inquiry |
Clec7a-2204M | Recombinant Mouse Clec7a protein(Phe69-Leu244), His-tagged | +Inquiry |
CLEC7A-1473H | Recombinant Human CLEC7A Protein, GST-tagged | +Inquiry |
CLEC7A-732R | Recombinant Rhesus Macaque CLEC7A Protein, His (Fc)-Avi-tagged | +Inquiry |
Clec7a-798M | Recombinant Mouse Clec7a Protein, His-tagged | +Inquiry |
◆ Lysates | ||
CLEC7A-2455MCL | Recombinant Mouse CLEC7A cell lysate | +Inquiry |
CLEC7A-001HCL | Recombinant Human CLEC7A cell lysate | +Inquiry |
CLEC7A-760HCL | Recombinant Human CLEC7A cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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