CXCR5

  • Official Full Name

    chemokine (C-X-C motif) receptor 5

  • Overview

    This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitts lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
  • Synonyms

    CXCR5; chemokine (C-X-C motif) receptor 5; BLR1; CD185; MDR15; C-X-C chemokine receptor type 5; CXC-R5; CXCR-5; MDR-15; monocyte-derived receptor 15; Burkitt lymphoma receptor 1, GTP-binding protein; Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif) receptor 5);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Chicken
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Rat
  • Rattus norvegicus (Rat)
  • E.coli
  • E.coli expression system
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Flag
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCR5-912H Active Recombinant Human CXCR5 Full Length Transmembrane protein(VLPs) HEK293 N/A Asn 2 - Phe 372
Human CXCR5-395H Active Recombinant Human CXCR5 Full Length Transmembrane protein(Nanodisc) HEK293 N/A
Human CXCR5-426HCL Recombinant Human CXCR5 cell lysate N/A
Human CXCR5-110HF Recombinant Full Length Human CXCR5 Protein In Vitro Cell Free System
Human CXCR5-1084HFL Recombinant Human CXCR5 protein, His&Flag-tagged HEK293 His&Flag 1-372 aa
Human CXCR5-111HF Recombinant Full Length Human CXCR5 Protein, GST-tagged In Vitro Cell Free System GST 1-372aa
Human CXCR5-3349H Recombinant Human CXCR5 protein, His-tagged E.coli His Val101~Phe372
Human CXCR5-3350H Recombinant Human CXCR5 protein, His-GST-tagged E.coli His/GST Met1~Pro55
Human CXCR5-3351H Recombinant Human CXCR5 protein, His-tagged E.coli His Met1~Pro55
Mouse CXCR5-4111M Recombinant Mouse CXCR5 Protein Mammalian Cell His
Mouse CXCR5-2102M-B Recombinant Mouse CXCR5 Protein Pre-coupled Magnetic Beads HEK293
Mouse CXCR5-2102M Recombinant Mouse CXCR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCR5-1695R Recombinant Rat CXCR5 Protein Mammalian Cell His
Rat CXCR5-1354R Recombinant Rat CXCR5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCR5-1354R-B Recombinant Rat CXCR5 Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL23597HF Recombinant Full Length Human C-X-C Chemokine Receptor Type 5(Cxcr5) Protein, His-Tagged E.coli expression system His Full Length (1-372)
Rattus norvegicus (Rat) RFL32348RF Recombinant Full Length Rat C-X-C Chemokine Receptor Type 5(Cxcr5) Protein, His-Tagged E.coli expression system His Full Length (1-374)
Chicken CXCR5-2601C Recombinant Chicken CXCR5 Mammalian Cell His
Kit-1200 CXCR5 (BLR1) CHO-K1 β-Arrestin GPCR Assay Kit N/A
Kit-1201 CHO-K1 CXCR5 Bioassay Kit N/A
Kit-1060 HIV-1 Protease Assay Kit N/A
Kit-1202 cAMP CXCR5 (BLR1) CHO-K1 GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CXCR5 involved in several pathways and played different roles in them. We selected most pathways CXCR5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCR5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL12A;Il2;GH1;TNFRSF6B;IL2RB;IL18R1;CCL21;BMPR1A;CCL20B
Chemokine signaling pathwayARRB1;SRC;CDC42;Ccl21a;CCL21;HRAS;PIK3R1;PLCB4;GNB1

CXCR5 has several biochemical functions, for example, C-X-C chemokine receptor activity, G-protein coupled receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCR5 itself. We selected most functions CXCR5 had, and list some proteins which have the same functions with CXCR5. You can find most of the proteins on our site.

Function Related Protein
C-X-C chemokine receptor activityCCBP2;CXCR2;CXCR6;CXCR5;CXCR4;CXCR4A;CXCR3.1;CCR9A;CXCR7
G-protein coupled receptor activityOLFCW1;TAS2R103;GPR6;TAAR12E;TAAR14J;NPFFR1L1;RGR;FZD2;TAAR6
protein bindingAnks6;TRPV6;TMSB4Y;OSBPL6;FAM111A;LBR;PI4KA;PDCD6;DNASE1

CXCR5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCR5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCR5.

GNAI2; GNAO1; GNB3; GNAQ; CXCR4; GNA13

Gene Family

Chemokines Cytokines

Research Area

Related articles

Klimatcheva, E; Pandina, T; et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC IMMUNOLOGY 16:-(2015).
Spaan, M; Kreefft, K; et al. CD4(+)CXCR5(+) T cells in chronic HCV infection produce less IL-21, yet are efficient at supporting B cell responses. JOURNAL OF HEPATOLOGY 62:303-310(2015).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
01/25/2022

    Such support ensures researchers have access to reliable tools and expertise, facilitating their investigations into the functions, mechanisms, and disease relevance of CXCR5 protein.

    10/12/2021

      Using CXCR5 protein in trials provides advantages such as its involvement in cellular processes and its disease associations.

      09/27/2021

        A manufacturer can serve as a collaborative partner, engaging in discussions, and exchanging knowledge with researchers.

        Q&As (5)

        Ask a question
        Are there any clinical studies targeting CXCR5 protein for therapeutic purposes? 12/21/2022

        Yes, there are ongoing clinical studies investigating the use of CXCR5 inhibitors for the treatment of autoimmune diseases.

        Is there a genetic component to variations in CXCR5 protein expression? 07/01/2022

        Yes, genetic variations can influence the expression and function of CXCR5 protein, contributing to individual differences in immune responses.

        Are there any diagnostic tests that measure CXCR5 protein levels? 05/20/2018

        Yes, there are research-based diagnostic tests that measure CXCR5 protein levels, but they are not yet widely used in clinical practice.

        How is CXCR5 protein involved in the development of lymphoid tissues? 06/27/2017

        CXCR5 protein is critical for the organization and development of lymphoid tissues, such as lymph nodes and spleen.

        Can CXCR5 protein be used as a biomarker for disease activity? 12/03/2016

        Research suggests that CXCR5 protein levels may serve as a biomarker for disease activity in certain autoimmune and inflammatory conditions.

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