dhfr
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  • Official Full Name
  • dihydrofolate reductase
  • Background
  • Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014]
  • Synonyms
  • DHFR; dihydrofolate reductase; DYR; DHFRP1;
Cat.#:DHFR-2586HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human DHFR Protein, GST-tagged
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Cat.#:DHFR-11966HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DHFR, GST-tagged
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Cat.#:DHFR-28331THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human DHFR, His-tagged
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Cat.#:DHFR-42HTag:His
Source (Host):E.coliSpecies:Human
Product nameRecombinant Human DHFR protein, His-tagged
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Cat.#:DHFR-4556MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse DHFR Protein
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Cat.#:DHFR-1721CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken DHFR
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Cat.#:DHFR-9289ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish DHFR
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Cat.#:DHFR-375HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Dihydrofolate Reductase, His-tagged
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Cat.#:Dhfr-3422MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Dihydrofolate Reductase, His-tagged
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Cat.#:DHFR-6946HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human DHFR 293 Cell Lysate
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Cat.#:DHFR-353HCLTag:
Source (Host):Species:Hamster
Product nameRecombinant Human DHFR cell lysate
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Cat.#:Kit-2097Tag:
Source (Host):Species:
Product nameDihydrofolate Reductase Colorimetric Activity Kit
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Cat.#:Kit-2100Tag:
Source (Host):Species:
Product nameDihydrofolate Reductase Inhibitor Screening Kit
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Involved Pathway

Dhfr involved in several pathways and played different roles in them. We selected most pathways Dhfr participated on our site, such as Cell Cycle, Cell Cycle, Mitotic, E2F mediated regulation of DNA replication, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dhfr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cell Cycle
SFN; CTDNEP1A; FGFR1OP; BUB3; CCNE2; SETA; CKAP5; CENPQ; RAD17; MCM7
Cell Cycle, Mitotic
MAPRE1; WAPAL; MCM10; NDEL1; CTDNEP1B; NEDD1; RCC2; LEMD3; NIPBLB; CEP135
E2F mediated regulation of DNA replication
DHFR
E2F transcription factor network
RYBP; CDKN2C; HBP1; PRMT5; TRIM28; E2F6; RBBP8; CES5A; CES1; CES3
Fluoropyrimidine Activity
DPYS; DPYD; DHFR; TYMP; CES1; UPP2; SLC22A7
Folate biosynthesis
SPR; QDPR; SPRA; GCH1; GCH2; ALPL; ALPPL2; FPGS; MOCS1; PTS
G1/S Transition
CKS1B; MYCA; DHFR
G1/S-Specific Transcription
DHFR

Protein Function

Dhfr has several biochemical functions, for example, NADPH binding, dihydrofolate reductase activity, drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Dhfr itself. We selected most functions Dhfr had, and list some proteins which have the same functions with Dhfr. You can find most of the proteins on our site.
Function
Related Protein
Function NADPH binding
Related Protein CRYZ; HMGCR; DHFR; DECR1; TP53I3; KCNAB1; FASN; QDPR; MTRR; GRHPR
Function dihydrofolate reductase activity
Related Protein DHFR; DHFRL1
Function drug binding
Related Protein PNP; HMGCS1; DHODH; PPP3CA; GRIK1; P2RX1; FASN; PPARG; ABP1; RARB
Function folic acid binding
Related Protein FOLR3; GNMT; DAAM2; DHFR; TYMS; FTCD; FOLR1; FOLR2; MTHFS; SLC46A1
Function mRNA binding
Related Protein MRPS7; RPS26; CELF3; PURB; DHFR; RBFOX1L; RBMY1A1; CCDC55; SNRNP70; ITM2B
Function methotrexate binding
Related Protein DHFR; FOLR2; FOLR1; DAAM2

Interacting Protein

Dhfr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dhfr here. Most of them are supplied by our site. Hope this information will be useful for your research of Dhfr.
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Dhfr Related Articles

Ershler, MA; Olovnikova, NI; et al. Production of IgM monoclonal antibodies in DG44 cells. APPLIED BIOCHEMISTRY AND MICROBIOLOGY 50:819-828(2014).
Nasseri, SS; Ghaffari, N; et al. Increased CHO cell fed-batch monoclonal antibody production using the autophagy inhibitor 3-MA or gradually increasing osmolality. BIOCHEMICAL ENGINEERING JOURNAL 91:37-45(2014).