Recombinant Human DHFR Protein, GST-tagged
Cat.No. : | DHFR-2586H |
Product Overview : | Human DHFR full-length ORF ( XP_937759.1, 1 a.a. - 187 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2014] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 47.9 kDa |
AA Sequence : | MVGSLNCIVAVSQNMGIGKNGDLPW PPLRNEFRYFQRMTTTSSVEGKQNL VIMGKKTWFSIPEKNRPLKGRINLV LSRELKEPPQGAHFLSRSLDDALKL TEQPELANKVDMVWIVGGSSVYKEA MNHPGHLKLFVTRIMQDFESDTFFP EIDLEKYKLLPEYPGVLSDVQEEKG IKYKFEVYEKND |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | DHFR dihydrofolate reductase [ Homo sapiens ] |
Official Symbol : | DHFR |
Synonyms : | DHFR; dihydrofolate reductase; DYR; DHFRP1; |
Gene ID : | 1719 |
mRNA Refseq : | NM_000791 |
Protein Refseq : | NP_000782 |
MIM : | 126060 |
UniProt ID : | P00374 |
Products Types
◆ Recombinant Protein | ||
DHFR-2354M | Recombinant Mouse DHFR Protein, His (Fc)-Avi-tagged | +Inquiry |
DHFR-0618H | Recombinant Human DHFR Protein (M1-D187), His tagged | +Inquiry |
Dhfr-2545M | Recombinant Mouse Dhfr Protein, Myc/DDK-tagged | +Inquiry |
DHFR-755H | Recombinant Human DHFR Protein, His (Fc)-Avi-tagged | +Inquiry |
DHFR-0617H | Recombinant Human DHFR Protein (M1-D187), Tag Free | +Inquiry |
◆ Lysates | ||
DHFR-6946HCL | Recombinant Human DHFR 293 Cell Lysate | +Inquiry |
DHFR-353HCL | Recombinant Human DHFR cell lysate | +Inquiry |
◆ Assay kits | ||
Kit-2100 | Dihydrofolate Reductase Inhibitor Screening Kit | +Inquiry |
Kit-2097 | Dihydrofolate Reductase Colorimetric Activity Kit | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
- Q&As
- Reviews
Q&As (5)
Ask a questionMethotrexate is a common DHFR inhibitor drug used in cancer treatment.
Yes, scientists continue to research and develop new DHFR inhibitors with improved efficacy and reduced side effects for various clinical applications.
Yes, drug-resistant strains have emerged due to mutations in DHFR genes, reducing the effectiveness of DHFR inhibitor drugs.
Yes, common side effects of DHFR inhibitors include nausea, vomiting, decreased blood cell counts, and liver toxicity.
Trimethoprim is an antibiotic that inhibits DHFR in bacteria.
Customer Reviews (3)
Write a reviewThe DHFR protein offered by the manufacturer is of exceptional quality, making it an ideal choice to fulfill my experimental needs.
Another crucial aspect where the manufacturer excels is their efficient supply chain management.
The technical support provided by the manufacturer is invaluable in overcoming experimental hurdles and optimizing the utilization of DHFR protein.
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