DNASE1
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Official Full Name
deoxyribonuclease I
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Overview
This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. -
Synonyms
DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; Deoxyribonuclease 1; Deoxyribonuclease1; DeoxyribonucleaseI; DNASE 1; DNase I lysosomal; DNaseI; DNL 1; DRNI; FLJ38093; Human urine deoxyribonuclease I; DNase I, lysosomal;
- Recombinant Proteins
- Cell & Tissue Lysates
- Therapeutic Proteins
- Protein Pre-coupled Magnetic Beads
- Native Proteins
- Others
- Bovine
- Chicken
- Cynomolgus Monkey
- Human
- Mouse
- Rat
- Zebrafish
- Bovine
- CHO
- CHO Cell
- E. coli
- E.coli
- HEK293
- Human Cell
- In Vitro Cell Free System
- Mammalian Cell
- Pancreas
- Wheat Germ
- C
- His
- Fc
- Fc|His
- GST
- GST|His
- His (Fc)
- Avi
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- DNASE1 Related Articles
DNASE1 involved in several pathways and played different roles in them. We selected most pathways DNASE1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with DNASE1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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DNASE1 has several biochemical functions, for example, actin binding, deoxyribonuclease I activity, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNASE1 itself. We selected most functions DNASE1 had, and list some proteins which have the same functions with DNASE1. You can find most of the proteins on our site.
Function | Related Protein |
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actin binding | MARCKSL1;SPTBN2;DIAPH1;PARVAB;MYO1C;WASF3;CCDC88A;MSNB;ALDOA |
deoxyribonuclease I activity | DNASE1;DICER1 |
endodeoxyribonuclease activity | DNASE2A;ERCC5;APEX1;MBD4;MRE11A;ZRANB3;DNASE1L3;DNASE1L3L;ERCC4 |
protein binding | JAGN1;PIH1D3;PPM1G;NOL4;PPP3R2;TEAD2;MSTN;CLEC18A;UBASH3B |
DNASE1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNASE1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DNASE1.
- Q&As
- Reviews
Q&As (7)
Ask a questionDNASE1 helps degrade DNA in apoptotic cells, ensuring proper clearance and preventing inflammation.
DNASE1 deficiency can contribute to autoimmune diseases like SLE by allowing self-DNA accumulation.
DNASE1 regulates inflammation and immune responses by controlling extracellular DNA levels.
DNASE1 aids in resolving inflammation and promoting tissue repair by degrading DNA in damaged tissues.
DNASE1 maintains the stability and integrity of extracellular DNA, preventing inappropriate immune activation.
Changes in DNASE1 function can increase susceptibility to chronic inflammation and autoimmune disorders.
DNASE1 prevents the accumulation of self-DNA, reducing the risk of autoimmune reactions.
Customer Reviews (3)
Write a reviewDependable antibody validation, vital for our immunoprecipitation studies.
Top-quality protein purification service, essential for our lab's work.
Fast and reliable protein expression, a critical part of our projects.
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