|Official Full Name||deoxyribonuclease I|
|Background||This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.|
|Synonyms||DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; Deoxyribonuclease 1; Deoxyribonuclease1; DeoxyribonucleaseI; DNASE 1; DNase I lysosomal; DNaseI; DNL 1; DRNI; FLJ38093; Human urine deoxyribonuclease I; DNase I, lysosomal|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
dnase1 involved in several pathways and played different roles in them. We selected most pathways dnase1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dnase1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
dnase1 has several biochemical functions, for example, actin binding, deoxyribonuclease I activity, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dnase1 itself. We selected most functions dnase1 had, and list some proteins which have the same functions with dnase1. You can find most of the proteins on our site.
|actin binding||MAEA; SMYHC3; WASB; PDLIM5; CAPZA1; WASH; WASL; EPB41L2; MICAL2B; MTAP1B|
|deoxyribonuclease I activity||DNASE1; DICER1|
|endodeoxyribonuclease activity||RPS3; DNASE1L2; MRE11A; ERCC5; DNASE1L3L; ERCC4; DNASE1L1; DNASE2A; DNASE1L3; DNASE1|
|protein binding||C10orf33; MYL6; WIF1; RNF10; RIN1; C5orf30; CCDC109A; GRB2; CCDC155; AGRN|
dnase1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dnase1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dnase1.