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Official Full Name deoxyribonuclease I
Background This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Synonyms DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; Deoxyribonuclease 1; Deoxyribonuclease1; DeoxyribonucleaseI; DNASE 1; DNase I lysosomal; DNaseI; DNL 1; DRNI; FLJ38093; Human urine deoxyribonuclease I; DNase I, lysosomal
    • Species :
    • Bovine
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • Bovine
    • CHO
    • CHO Cell
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Pancreas
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human DNASE1-10H Recombinant Human DNASE1 protein CHO Cell N/A
    Human DNASE1-12094H Recombinant Human DNASE1, GST-tagged E.coli GST
    Human DNASE1-1529H Recombinant Human DNASE1 protein, His-tagged E.coli His
    Human DNASE1-195H Recombinant Human DNASE1 Mammalian Cell His
    Human DNASE1-207H Recombinant Human DNASE1, His tagged Human Cell Fc
    Human DNASE1-2774H Recombinant Human DNASE1 Protein, GST-tagged Wheat Germ GST
    Human DNASE1-775H Recombinant Human DNASE1 Protein, GST-His-tagged E.coli GST/His
    Human DNASE1-866HCL Recombinant Human DNASE1 cell lysate Human Cell N/A
    Human DNASE1-P001H Recombinant Human DNASE1 therapeutic protein CHO N/A
    Mouse DNASE1-4726M Recombinant Mouse DNASE1 Protein Mammalian Cell His
    Rat DNASE1-1917R Recombinant Rat DNASE1 Protein Mammalian Cell His
    Cynomolgus Monkey IL6ST-144C Recombinant Cynomolgus DNASE1, Fc tagged Human Cell Fc/His
    Cynomolgus Monkey IL6ST-145C Recombinant Cynomolgus DNASE1, His tagged Human Cell His
    Bovine DNASE1-1227B Recombinant Bovine Deoxyribonuclease I Bovine N/A
    Bovine DNASE1-711B Recombinant bovine DNASE1 Protein CHO N/A
    Bovine DNASE1-8333B Native Bovine DNASE1 Pancreas N/A
    Chicken DNASE1-7097C Recombinant Chicken DNASE1 Mammalian Cell His
    Zebrafish DNASE1-781Z Recombinant Zebrafish DNASE1 Mammalian Cell His
    CMC04 DNase I E.coli N/A

    dnase1 involved in several pathways and played different roles in them. We selected most pathways dnase1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with dnase1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    dnase1 has several biochemical functions, for example, actin binding, deoxyribonuclease I activity, endodeoxyribonuclease activity. Some of the functions are cooperated with other proteins, some of the functions could acted by dnase1 itself. We selected most functions dnase1 had, and list some proteins which have the same functions with dnase1. You can find most of the proteins on our site.

    Function Related Protein
    deoxyribonuclease I activity DNASE1; DICER1
    endodeoxyribonuclease activity RPS3; DNASE1L2; MRE11A; ERCC5; DNASE1L3L; ERCC4; DNASE1L1; DNASE2A; DNASE1L3; DNASE1
    protein binding C10orf33; MYL6; WIF1; RNF10; RIN1; C5orf30; CCDC109A; GRB2; CCDC155; AGRN

    dnase1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with dnase1 here. Most of them are supplied by our site. Hope this information will be useful for your research of dnase1.

    Vogel, B; Frantz, S; et al. Determination of DNase activity by degradation of ethidium bromide-DNA complexes using a fluorescence plate reader. ANALYTICAL BIOCHEMISTRY 471:73-79(2015).
    Fragoulis, GE; Vakrakou, AG; et al. Impaired degradation and aberrant phagocytosis of necrotic cell debris in the peripheral blood of patients with primary Sjogren's syndrome. JOURNAL OF AUTOIMMUNITY 56:12-22(2015).

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