Recombinant Human DNASE1 Protein, GST-tagged

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Recombinant Human DNASE1 Protein, GST-tagged

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Cat.No. : DNASE1-2774H
Product Overview : Human DNASE1 full-length ORF ( NP_005214.2, 1 a.a. - 282 a.a.) recombinant protein with GST-tag at N-terminal.
Description : This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 57.8 kDa
AA Sequence : MRGMKLLGALLALAA LLQGAVSLKIAAFNI QTFGETKMSNATLVS YIVQILSRYDIALVQ EVRDSHLTAVGKLLD NLNQDAPDTYHYVVS EPLGRNSYKERYLFV YRPDQVSAVDSYYYD DGCEPCGNDTFNREP AIVRFFSRFTEVREF AIVPLHAAPGDAVAE IDALYDVYLDVQEKW GLEDVMLMGDFNAGC SYVRPSQWSSIRLWT SPTFQWLIPDSADTT ATPTHCAYDRIVVAG MLLRGAVVPDSALPF NFQAAYGLSDQLAQA ISDHYPVEVMLK
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Quality Control Testing :

12.5% SDS-PAGE Stained with Coomassie Blue.

Gene Name : DNASE1 deoxyribonuclease I [ Homo sapiens ]
Official Symbol : DNASE1
Synonyms : DNASE1; deoxyribonuclease I; DNL1; deoxyribonuclease-1; Dornase alfa; DNase I, lysosomal; human urine deoxyribonuclease I; DRNI; FLJ38093; FLJ44902; DKFZp686H0155;
Gene ID : 1773
mRNA Refseq : NM_005223
Protein Refseq : NP_005214
MIM : 125505
UniProt ID : P24855

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