Native Human Coagulation Factor II (thrombin)

• Cat.No.: F2-5285H
• Product Overview: Native Human F2 was expressedin human plasma.

Specification

• Species: Human
• Source: Human Plasma
• Tag: Non
• Description: F2is proteolytically cleaved to form thrombin in the first step of thecoagulation cascade which ultimately results in the stemming of blood loss.F2 also plays a role in maintaining vascular integrity during development andpostnatal life. Mutations in F2 lead to various forms of thrombosis anddysprothrombinemia.
• Form: Liquidin 0.1 M NaH2PO4, pH 6.5.
• Concentration: 5.0mg/ml
• Molecular Weight: 34.3 kDa
• Specific Activity: Determinedusing a fibrinogen clotting assay.
• Storage: Store in workingaliquots at -20°C. Avoid repeated freeze-thaw cycles.
• Pathways: Angiopoietinreceptor Tie2-mediated signaling; Blood Clotting Cascade; Cell surfaceinteractions at the vascular wall; Class A/1(Rhodopsin-like receptors); CommonPathway; Complement and Coaqulation Cascades; Diabetes pathways; FOXA2 andFOXA3 transcription factor networks; Extrinsic Pathway; Formation of FibrinClot (Clotting Cascade); Hemostasis; Intrinsic Pathway; Regulation of actincytoskeleton; Selenium Pathway; Signal Transduction

Gene Information

• Gene Name: F2 coagulation factor II (thrombin) [ Homosapiens ]
• Official Symbol: F2
• Synonyms: F2; coagulation factor II (thrombin); PT; prothrombin; serineprotease; OTTHUMP00000197117; OTTHUMP00000197118; OTTHUMP00000233661;prothrombin B-chain; EC 3.4.21.5; EC 3.4.21; Prothrombin; Coagulation factorII; Activation peptide fragment 1; Activation peptide fragment 2; Thrombinlight chain; Thrombin heavy chain
• Gene ID: 2147
• mRNA Refseq: NM_000506
• Protein Refseq: NP_000497
• MIM: 176930
• UniProt ID: P00734
• Chromosome Location: 11p11
• Function: peptidaseactivity;protein binding; serine-type endopeptidase activity; heparin binding;calcium ion binding; growth factor activity; receptor binding; contributes toreceptor binging; thrombospondin receptor activity