Recombinant Human Coagulation Factor II (F2) protein, His-tagged
Cat.No. : | F2-305H |
Product Overview : | Recombinant Human Coagulation Factor II (F2) protein (Gln25-Glu622), fused to His tag at C-terminus, was expressed in human 293 cells (HEK293). |
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Description : | Prothrombin is also known as coagulation factor II (F2),which can be cleaved into the following 4 chains: activation peptide fragment 1, activation peptide fragment 2, thrombin light chain and thrombin heavy chain. Coagulation factor II (F2) is able to form a heterodimer with SERPINA5. The mutations of F2 gene can result in a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. Furthermore, thrombin converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Coagulation factor II (F2) can also play an important role in blood homeostasis, inflammation and wound healing. |
Source : | HEK293 |
Species : | Human |
Tag : | His |
Form : | Lyophilized from 0.22 um filtered solution in PBS, pH7.4, 10% trehalose. |
Molecular Mass : | The protein has a calculated MW of 69.5 kDa. The protein migrates as 85-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Protein length : | 598 |
Endotoxin : | Less than 1.0 EU per ug by the LAL method. |
Purity : | >95% as determined by reduced SDS-PAGE. |
Storage : | For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower. Please avoid repeated freeze-thaw cycles. This product is stable after storage at: -20 centigrade to -70 centigrade for 12 months in lyophilized state; -70 centigrade for 3 months under sterile conditions after reconstitution. |
Reconstitution : | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents. |
Gene Name : | F2 |
Official Symbol : | F2 |
Synonyms : | F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1 |
Gene ID : | 2147 |
mRNA Refseq : | NM_000506 |
Protein Refseq : | NP_000497 |
MIM : | 176930 |
UniProt ID : | P00734 |
Products Types
◆ Recombinant Protein | ||
F2-366R | Recombinant Rat F2 Protein, His-tagged | +Inquiry |
F2-955H | Recombinant Human F2 Protein, MYC/DDK-tagged | +Inquiry |
F2-069H | Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
F2-3610H | Recombinant Human F2 Protein, GST-tagged | +Inquiry |
F2-1186M | Active Recombinant Mouse F2 protein(Met1-Gly618), His-tagged | +Inquiry |
◆ Native Protein | ||
F2-5287M | Native Mouse Coagulation Factor II | +Inquiry |
Prothrombin-270B | Active Native Bovine Prothrombin | +Inquiry |
F2-1882H | Native Human Coagulation Factor II | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
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