Recombinant Human F2 Protein, GST-tagged
Cat.No. : | F2-3610H |
Product Overview : | Human F2 full-length ORF ( NP_000497.1, 1 a.a. - 622 a.a.) recombinant protein with GST-tag at N-terminal. |
- Specification
- Gene Information
- Related Products
Description : | Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
Source : | Wheat Germ |
Species : | Human |
Tag : | GST |
Molecular Mass : | 96.4 kDa |
AA Sequence : | MAHVRGLQLPGCLALAALCSLVHSQ HVFLAPQQARSLLQRVRRANTFLEE VRKGNLERECVEETCSYEEAFEALE SSTATDVFWAKYTACETARTPRDKL AACLEGNCAEGLGTNYRGHVNITRS GIECQLWRSRYPHKPEINSTTHPGA DLQENFCRNPDSSTTGPWCYTTDPT VRRQECSIPVCGQDQVTVAMTPRSE GSSVNLSPPLEQCVPDRGQQYQGRL AVTTHGLPCLAWASAQAKALSKHQD FNSAVQLVENFCRNPDGDEEGVWCY VAGKPGDFGYCDLNYCEEAVEEETG DGLDEDSDRAIEGRTATSEYQTFFN PRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMS PWQVMLFRKSPQELLCGASLISDRW VLTAAHCLLYPPWDKNFTENDLLVR IGKHSRTRYERNIEKISMLEKIYIH PRYNWRENLDRDIALMKLKKPVAFS DYIHPVCLPDRETAASLLQAGYKGR VTGWGNLKETWTANVGKGQPSVLQV VNLPIVERPVCKDSTRIRITDNMFC AGYKPDEGKRGDACEGDSGGPFVMK SPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE |
Applications : | Enzyme-linked Immunoabsorbent Assay Western Blot (Recombinant protein) Antibody Production Protein Array |
Notes : | Best use within three months from the date of receipt of this protein. |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer. |
Gene Name : | F2 coagulation factor II (thrombin) [ Homo sapiens ] |
Official Symbol : | F2 |
Synonyms : | F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1; |
Gene ID : | 2147 |
mRNA Refseq : | NM_000506 |
Protein Refseq : | NP_000497 |
MIM : | 176930 |
UniProt ID : | P00734 |
Products Types
◆ Recombinant Protein | ||
F2-1356R | Recombinant Rhesus Macaque F2 Protein, His (Fc)-Avi-tagged | +Inquiry |
F2-069H | Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
F2-1450R | Recombinant Rat F2 Protein, His-tagged | +Inquiry |
F2-789H | Recombinant Human F2 Protein | +Inquiry |
F2-995M | Recombinant Mouse F2 Protein, MYC/DDK-tagged | +Inquiry |
◆ Native Protein | ||
F2-275B | Active Native Bovine α-Thrombin-DFP | +Inquiry |
F2-5286R | Native Rat Coagulation Factor II | +Inquiry |
F2-303R | Native Rat Thrombin | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (5)
Ask a questionThe F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.
Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.
The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.
Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.
Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.
Customer Reviews (3)
Write a reviewQuality control is evident. This product ensures accuracy in our studies.
Our lab swears by this protein. Fast shipping is a definite bonus.
Consistently reliable. The shipping speed is appreciated in our fast-paced lab.
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