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Recombinant Human F2 Protein, GST-tagged

Cat.No. : F2-3610H
Product Overview : Human F2 full-length ORF ( NP_000497.1, 1 a.a. - 622 a.a.) recombinant protein with GST-tag at N-terminal.
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  • Gene Information
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Description : Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Source : Wheat Germ
Species : Human
Tag : GST
Molecular Mass : 96.4 kDa
AA Sequence : MAHVRGLQLPGCLALAALCSLVHSQ HVFLAPQQARSLLQRVRRANTFLEE VRKGNLERECVEETCSYEEAFEALE SSTATDVFWAKYTACETARTPRDKL AACLEGNCAEGLGTNYRGHVNITRS GIECQLWRSRYPHKPEINSTTHPGA DLQENFCRNPDSSTTGPWCYTTDPT VRRQECSIPVCGQDQVTVAMTPRSE GSSVNLSPPLEQCVPDRGQQYQGRL AVTTHGLPCLAWASAQAKALSKHQD FNSAVQLVENFCRNPDGDEEGVWCY VAGKPGDFGYCDLNYCEEAVEEETG DGLDEDSDRAIEGRTATSEYQTFFN PRTFGSGEADCGLRPLFEKKSLEDK TERELLESYIDGRIVEGSDAEIGMS PWQVMLFRKSPQELLCGASLISDRW VLTAAHCLLYPPWDKNFTENDLLVR IGKHSRTRYERNIEKISMLEKIYIH PRYNWRENLDRDIALMKLKKPVAFS DYIHPVCLPDRETAASLLQAGYKGR VTGWGNLKETWTANVGKGQPSVLQV VNLPIVERPVCKDSTRIRITDNMFC AGYKPDEGKRGDACEGDSGGPFVMK SPFNNRWYQMGIVSWGEGCDRDGKY GFYTHVFRLKKWIQKVIDQFGE
Applications : Enzyme-linked Immunoabsorbent Assay
Western Blot (Recombinant protein)
Antibody Production
Protein Array
Notes : Best use within three months from the date of receipt of this protein.
Storage : Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
Storage Buffer : 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.
Gene Name : F2 coagulation factor II (thrombin) [ Homo sapiens ]
Official Symbol : F2
Synonyms : F2; coagulation factor II (thrombin); prothrombin; serine protease; prothrombin B-chain; PT; THPH1;
Gene ID : 2147
mRNA Refseq : NM_000506
Protein Refseq : NP_000497
MIM : 176930
UniProt ID : P00734

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Can you discuss the role of the F2 gene in the synthesis of vitamin K-dependent clotting factors, and how disruptions in this process may lead to coagulation disorders? 04/10/2022

The F2 gene plays a crucial role in the synthesis of vitamin K-dependent clotting factors, including prothrombin. Disruptions in this process, often due to genetic or nutritional factors, can contribute to coagulation disorders, impacting hemostasis and blood clotting.

How is the F2 gene regulated at the transcriptional level, and what factors influence prothrombin synthesis in hepatocytes? 08/07/2021

Transcriptional regulation of the F2 gene involves factors like vitamin K-dependent gamma-carboxylation. Hepatocytes synthesize prothrombin under the influence of vitamin K and other coagulation factors.

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation. 04/07/2020

The F2 gene encodes prothrombin, a crucial factor in blood coagulation. Prothrombin is converted to thrombin, a key enzyme in the clotting cascade, facilitating fibrin formation.

What are the implications of genetic variations in the F2 gene, particularly polymorphisms, on prothrombin function and susceptibility to thrombotic or bleeding disorders? 11/20/2019

Genetic variations in F2, including polymorphisms, can influence prothrombin function. Certain variants may predispose individuals to thrombotic or bleeding disorders.

How does genetic variation in the F2 gene impact prothrombin levels, and what are the consequences for an individual's risk of thrombotic events? 04/16/2018

Genetic variations in the F2 gene can influence prothrombin levels, affecting an individual's propensity for thrombotic events. Certain variants may predispose individuals to a higher or lower risk of abnormal blood clot formation.

Customer Reviews (3)

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Reviews
01/01/2022

    Quality control is evident. This product ensures accuracy in our studies.

    01/27/2019

      Our lab swears by this protein. Fast shipping is a definite bonus.

      12/18/2018

        Consistently reliable. The shipping speed is appreciated in our fast-paced lab.

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