Active Native Bovine α-Thrombin-FPRck (FPR-CMK*)
Cat.No. : | F2-276B |
- Specification
- Gene Information
- Related Products
Description : | Alpha-thrombin is a highly specific serine protease generated by proteolytic activation of the zymogen prothrombin. During coagulation, thrombin cleaves fibrinogen to form fibrin, leading to the ultimate step in coagulation, the formation of a fibrin clot. Thrombin is also responsible for feedback activation of the procofactors factor V and factor VIII. Thrombin has also been reported to activate factor XIII and platelets, and also functions as a vasoconstrictor protein. The procoagulant activity of thrombin is arrested in two ways: 1) inhibition by either heparin cofactor II or the antithrombin III/heparin complex; or 2) complex formation with thrombomodulin. Formation of the thrombin/thrombomodulin complex results in the inability of thrombin to cleave fibrinogen and activate factors V and VIII, but increases the efficiency of thrombin for activation of the anticoagulant, protein C. |
Source : | Plasma |
Species : | Bovine |
Form : | 20 mM Hepes, 150 mM NaCl, pH 7.4 |
Bio-activity : | Fibrinogen clotting or chromogenic assay |
Molecular Mass : | 36700 |
Purity : | >95% by SDS-PAGE. NOT tissue/cell culture grade. Not tested for endotoxin. |
Characteristic : | Extinction coefficient:19.5, Percent carbohydrate: approximately 5%, Structure: two subunits, approximately Mr=6,000 and 31,000 |
Storage : | -80°C |
Gene Name : | F2?coagulation factor II (thrombin) [?Bos taurus?(cattle) ] |
Official Symbol : | F2 |
Synonyms : | prothrombin; thrombin |
Gene ID : | 280685 |
mRNA Refseq : | NM_173877 |
Protein Refseq : | NP_776302 |
UniProt ID : | P00735 |
Chromosome Location : | chromosome: 15 |
Pathway : | Cell surface interactions at the vascular wall, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem |
Function : | calcium ion binding; fibrinogen binding |
Products Types
◆ Recombinant Protein | ||
F2-1450R | Recombinant Rat F2 Protein, His-tagged | +Inquiry |
F2-366R | Recombinant Rat F2 Protein, His-tagged | +Inquiry |
F2-069H | Recombinant Human F2 Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
F2-3610H | Recombinant Human F2 Protein, GST-tagged | +Inquiry |
F2-907P | Recombinant Pig F2 Protein, His-tagged | +Inquiry |
◆ Native Protein | ||
F2-274B | Active Native Bovine α-Thrombin | +Inquiry |
F2-5285H | Native Human Coagulation Factor II (thrombin) | +Inquiry |
F2-73R | Native Rat Prothrombin | +Inquiry |
◆ Lysates | ||
F2-2124MCL | Recombinant Mouse F2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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