Recombinant Human F2 Protein, MYC/DDK-tagged

• Cat.No.: F2-955H
• Product Overview: Recombinant human F2 protein, fused to MYC/DDK tag at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 lead to various forms of thrombosis and dysprothrombinemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
• Molecular Mass: 67.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: coagulation factor II, thrombin[ Homo sapiens ]
• Official Symbol: F2
• Synonyms: PT; RPRGL2; THPH1
• Gene ID: 2147
• mRNA Refseq: NM_000506.4
• Protein Refseq: NP_000497
• MIM: 176930
• UniProt ID: P00734