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Official Full Name glutaredoxin 2
Background The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. GRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage.
Synonyms GLRX2; glutaredoxin 2; bA101E13.1; bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); GRX2; mitochondrial; CGI133; GLRX2_HUMAN; Glutaredoxin-2; OTTHUMP00000033766; OTTHUMP00000033767; CGI-133; TTR1; Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress; YDR513W
    • Species :
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Yeast
    • Zebrafish
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GLRX2-153H Recombinant Human GLRX2 Protein
    Human GLRX2-013H Recombinant Human GLRX2 Protein E.coli
    Human GLRX2-13312H Recombinant Human GLRX2, GST-tagged E.coli GST
    Human GLRX2-1828H Recombinant Human Glutaredoxin 2, His-tagged E.coli His
    Human GLRX2-19H Recombinant Human GLRX2 protein E.coli N/A
    Human GLRX2-27693TH Recombinant Human GLRX2 E.coli N/A
    Human GLRX2-27694TH Recombinant Human GLRX2, His-tagged E.coli His
    Human GLRX2-4976H Recombinant Human GLRX2 Protein, GST-tagged Wheat Germ GST
    Human GLRX2-5547H Recombinant Human GLRX2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human GLRX2-714HCL Recombinant Human GLRX2 cell lysate N/A
    Mouse Glrx2-3230M Recombinant Mouse Glrx2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat GLRX2-2571R Recombinant Rat GLRX2 Protein Mammalian Cell His
    Cynomolgus Monkey GLRX2-550C Recombinant Cynomolgus GLRX2 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque GLRX2-1875R Recombinant Rhesus monkey GLRX2 Protein, His-tagged Mammalian Cell His
    Zebrafish GLRX2-541Z Recombinant Zebrafish GLRX2 Mammalian Cell His
    Yeast GRX2-76Y Recombinant Yeast Glutaredoxin 2, His-tagged E.coli His

    glrx2 involved in several pathways and played different roles in them. We selected most pathways glrx2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with glrx2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    glrx2 has several biochemical functions, for example, 2 iron, 2 sulfur cluster binding, arsenate reductase (glutaredoxin) activity, electron carrier activity. Some of the functions are cooperated with other proteins, some of the functions could acted by glrx2 itself. We selected most functions glrx2 had, and list some proteins which have the same functions with glrx2. You can find most of the proteins on our site.

    Function Related Protein
    2 iron, 2 sulfur cluster binding NDUFV2; ISCUB; CIAPIN1; SDHB; FECH; FDX1; AOX3; AOX3L1; RFESD; UQCRFS1
    arsenate reductase (glutaredoxin) activity GLRX2
    electron carrier activity NDUFS2; HSD17B6; COX7A1; PTGESL; CYBA; GRX2; HAAO; NQO2; GCDHA; ME1
    glutathione disulfide oxidoreductase activity GLRX; GLRX2
    metal ion binding TRIM8A; Car14; ZIC2; EBF4; TPH1A; STAC; ZNHIT3; ZSCAN4C; ZNF397; DNAJA3A
    protein disulfide isomerase activity QSOX1; TXNDC11; PDIA2; PDIA5; ZNF169; PIGK; TMX4; PDIP5; ERP44; ITGB3
    protein disulfide oxidoreductase activity TXN2; TXNL1; PTGESL; ERO1LB; TXNRD1; GLRX2; ERO1L; CCS; GFER; CHCHD4

    glrx2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with glrx2 here. Most of them are supplied by our site. Hope this information will be useful for your research of glrx2.

    Upadhyaya, B; Tian, XL; et al. Expression and distribution of thiol-regulating enzyme glutaredoxin 2 (GRX2) in porcine ocular tissues. EXPERIMENTAL EYE RESEARCH 130:58-65(2015).
    Zhang, J; Yan, H; et al. Ultraviolet Radiation-Induced Cataract in Mice: The Effect of Age and the Potential Biochemical Mechanism. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 53:7276-7285(2012).

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