gp1bb

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gp1bb

Official Full Name glycoprotein Ib (platelet), beta polypeptide
Background Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
Synonyms GP1BB; glycoprotein Ib (platelet), beta polypeptide; platelet glycoprotein Ib beta chain; CD42c; Antigen CD42b beta; CD_antigen=CD42c; Flags: Precursor; Glycoprotein Ib (platelet) beta polypeptide; Glycoprotein Ib beta polypeptide; GP Ib beta; GP Ib beta subunit; GP1bbeta; GPIb beta; Nuclear localization signal deleted in velocardiofacial syndrome; Platelet glycoprotein Ib beta polypeptide; GPIb-beta; GP-Ib beta; antigen CD42b-beta; BS; GPIBB; BDPLT1
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • Human Cell
    • in vitro E. coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • SUMO
    • Myc
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human GP1BB-2247H Recombinant Human GP1BB, His tagged Human Cell His
    Human GP1BB-2588HCL Recombinant Human GP1BB cell lysate Human Cell N/A
    Human GP1BB-2723H Recombinant Human GP1BB Protein (26-206 aa), His-SUMO-Myc-tagged in vitro E. coli His/SUMO/Myc
    Human GP1BB-5132H Recombinant Human GP1BB Protein Wheat Germ N/A
    Mouse Gp1bb-5729M Recombinant Mouse Gp1bb protein, His & T7-tagged E.coli His/T7
    Rat GP1BB-1243RCL Recombinant Rat GP1BB cell lysate Human Cell N/A
    Rat GP1BB-2625R Recombinant Rat GP1BB Protein Mammalian Cell His
    Rat Gp1bb-5730R Recombinant Rat Gp1bb protein, His & T7-tagged E.coli His/T7
    Rat Gp1bb-8805R Recombinant Rat Gp1bb, Fc tagged Human Cell Fc
    Zebrafish GP1BB-7296Z Recombinant Zebrafish GP1BB Mammalian Cell His

    gp1bb involved in several pathways and played different roles in them. We selected most pathways gp1bb participated on our site, such as ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with gp1bb were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ECM-receptor interaction COL27A1A; COL6A6; THBS4; ITGB3B; COL6A3; SV2C; DAG1; ITGB8; LAMB1A; LAMB4
    Platelet activation MYLK4; PPP1R12A; ITGA2B; MYLK3; ACTG1; TBXA2R; ITPR3; LYN; VWF; PIK3CD
    Hematopoietic cell lineage CD3D; IL2RA; CD1C; IL4; IL1A; CD8B1; GP1BB; CD3G; THPO; CD1E, B2M

    gp1bb has several biochemical functions, for example, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by gp1bb itself. We selected most functions gp1bb had, and list some proteins which have the same functions with gp1bb. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TPCN2; GAGE5; TRIM28; TCEB3; POP5; CTLA4; MYBPC3; MYRIP; NKX2; DCP1A
    transmembrane signaling receptor activity TLR6; CLDN3; OR4D2; ICAM1; FZD3A; ADCYAP1R1A; KIR2DS2; GHRHRA; NRXN1; TLR5

    gp1bb has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with gp1bb here. Most of them are supplied by our site. Hope this information will be useful for your research of gp1bb.

    GP1BA; ezrA; GP9; VCAM1

    Morales, LD; Martin, C; et al. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 4:417-425(2006).
    Peng, YD; Berndt, MC; et al. The alpha 1 helix beta 13 strand spanning Leu214 to Val229 of platelet glycoprotein Ib alpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1. BLOOD 104:3971-3978(2004).

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