GP1BB

  • Official Full Name

    glycoprotein Ib (platelet), beta polypeptide

  • Overview

    Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described; however, the authenticity of this product has been questioned. Yet another less abundant GPIb beta mRNA species of 3.5 kb, expressed in nonhematopoietic tissues such as endothelium, brain and heart, was shown to result from inefficient usage of a non-consensus polyA signal in the neighboring upstream gene (SEPT5, septin 5). In the absence of polyadenylation from its own imperfect site, the SEPT5 gene produces read-through transcripts that use the consensus polyA signal of this gene.
  • Synonyms

    GP1BB; glycoprotein Ib (platelet), beta polypeptide; platelet glycoprotein Ib beta chain; CD42c; Antigen CD42b beta; CD_antigen=CD42c; Flags: Precursor; Glycoprotein Ib (platelet) beta polypeptide; Glycoprotein Ib beta polypeptide; GP Ib beta; GP Ib beta subunit; GP1bbeta; GPIb beta; Nuclear localization signal deleted in velocardiofacial syndrome; Platelet glycoprotein Ib beta polypeptide; GPIb-beta; GP-Ib beta; antigen CD42b-beta; BS; GPIBB; BDPLT1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • Papio cynocephalus (Yellow baboon)
  • Rat
  • Zebrafish
  • E.coli
  • E.coli expression system
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • In vitro E. coli expression system
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • Myc
  • His|T7
  • SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human GP1BB-2247H Recombinant Human GP1BB protein, His-tagged HEK293 His
Human GP1BB-2588HCL Recombinant Human GP1BB cell lysate Human Cell N/A
Human GP1BB-5132H Recombinant Human GP1BB Protein Wheat Germ N/A
Human GP1BB-5463HF Recombinant Full Length Human GP1BB Protein In Vitro Cell Free System
Human GP1BB-2723H Recombinant Human GP1BB Full Length Transmembrane protein (26-206 aa), His-SUMO-Myc-tagged In vitro E. coli expression system His-SUMO-Myc
Human GP1BB-15H Active Recombinant Human GP1BB Protein (26-147aa), C-His-tagged HEK293 C-His
Human GP1BB-4206H Recombinant Human GP1BB Protein (Met1-Cys147), C-His tagged Mammalian cells C-His
Mouse Gp1bb-5729M Recombinant Mouse Gp1bb protein, His & T7-tagged E.coli His/T7
Rat GP1BB-2625R Recombinant Rat GP1BB Protein Mammalian Cell His
Rat Gp1bb-5730R Recombinant Rat Gp1bb protein, His & T7-tagged E.coli His/T7
Rat Gp1bb-8805R Recombinant Rat Gp1bb, Fc tagged Human Cell Fc
Rat GP1BB-1243RCL Recombinant Rat GP1BB cell lysate Human Cell N/A
Rat GP1BB-2280R Recombinant Rat GP1BB Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat GP1BB-2280R-B Recombinant Rat GP1BB Protein Pre-coupled Magnetic Beads HEK293
Homo sapiens (Human) RFL7798HF Recombinant Full Length Human Platelet Glycoprotein Ib Beta Chain(Gp1Bb) Protein, His&Myc-Tagged E.coli expression system His&Myc
Mus musculus (Mouse) RFL15947MF Recombinant Full Length Mouse Platelet Glycoprotein Ib Beta Chain(Gp1Bb) Protein, His-Tagged E.coli expression system His
Papio cynocephalus (Yellow baboon) RFL22769PF Recombinant Full Length Papio Cynocephalus Platelet Glycoprotein Ib Beta Chain(Gp1Bb) Protein, His-Tagged E.coli expression system His
Zebrafish GP1BB-7296Z Recombinant Zebrafish GP1BB Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • GP1BB Related Articles
  • GP1BB Related Research Area

GP1BB involved in several pathways and played different roles in them. We selected most pathways GP1BB participated on our site, such as ECM-receptor interaction, Platelet activation, Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with GP1BB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
ECM-receptor interactionCOL27A1A;COL6A2;COL4A3;ITGA5;LAMB2;COL2A1;IBSP;LAMB1;LAMB1A
Platelet activationPLCB4;VASP;PLA2G4D;FYN;PRKG2;GUCY1A3;PRKACA;FGG;PRKACG
Hematopoietic cell lineageCD59;CD5;IL4R;HLA-DRB1;CD59A;Cd24a;CD1D2;CD14;CD3E

GP1BB has several biochemical functions, for example, protein binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GP1BB itself. We selected most functions GP1BB had, and list some proteins which have the same functions with GP1BB. You can find most of the proteins on our site.

Function Related Protein
protein bindingTMEM139;RAPGEF6;ZBTB7A;PRSS8;OGT;VPS25;DHX36;INPP4B;TRPC2
transmembrane signaling receptor activityOR103-4;EVI2A;TLR10;KLRC2;TLR18;TNFRSF10D;LGR4;FZD1;FZD7A

GP1BB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GP1BB here. Most of them are supplied by our site. Hope this information will be useful for your research of GP1BB.

GP1BA; ezrA; GP9; VCAM1

Morales, LD; Martin, C; et al. The interaction of von Willebrand factor-A1 domain with collagen: mutation G1324S (type 2M von Willebrand disease) impairs the conformational change in A1 domain induced by collagen. JOURNAL OF THROMBOSIS AND HAEMOSTASIS 4:417-425(2006).
Peng, YD; Berndt, MC; et al. The alpha 1 helix beta 13 strand spanning Leu214 to Val229 of platelet glycoprotein Ib alpha facilitates the interaction with von Willebrand factor: evidence from characterization of the epitope of monoclonal antibody AP1. BLOOD 104:3971-3978(2004).
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