Recombinant Human IL37 protein IL37-142H

Recombinant Human IL37 protein

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Cat.No. : IL37-142H Optional Service: Optional requirements on this protein
Product Overview : Recombinant Human IL37 was expressed in E. coli.
Description : Member of the IL-1 family, IL-37 functions to curb excessive inflammation. In partnership with SMAD3, IL-37 suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Out of the five isoforms for IL-37 (a-e), this product represents isoform B that is expressed in testis, colon, placenta, lung and lymph node similar to isoform A and C but is the only one found in kidneys.
Source : E. coli
Species : Human
Form : Lyophilized from a 0.2 μm filtered solution in PBS and DTT
Molecular Mass : 19.5 kDa
Endotoxin : <1.0 EU/μg of recombinant protein as determined by the LAL method.
Purity : >95%
Applications : Cell Assay
Storage : The lyophilized protein is stable for at least one year from date of receipt at -70 centigrade. Upon reconstitution, this cytokine can be stored in working aliquots at 2 centigrade - 8 centigrade for one month, or at -20 centigrade for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Reconstitution : Reconstitute at 100 μg/mL in sterile PBS
Figure :

Gene Name : IL37 interleukin 37 [ Homo sapiens ]
Official Symbol : IL37
Synonyms : IL37; interleukin 37; IL1F7, interleukin 1 family, member 7 (zeta); interleukin-37; FIL1; FIL1(ZETA); FIL1Z; IL 1F7; IL 1H4; IL 1RP1; interleukin 1; zeta; interleukin 1 homolog 4; interleukin 1 related protein; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1;
Gene ID : 27178
mRNA Refseq : NM_014439
Protein Refseq : NP_055254
MIM : 605510
UniProt ID : Q9NZH6
Chromosome Location : 2q12-q14.1
Function : cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 receptor binding;
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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