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Recombinant Human IL37, His-tagged

Cat.No. : IL37-370H
Product Overview : Human IL-37 (aa Val46-Asp218) is fused at the C-terminus to a His-tag.
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Description : IL-37 (IL-1F7; IL-1H4) belongs to the IL-1 family of proteins. It binds to the interleukin-18 receptor (IL-18R) but not to the IL-1 receptor. It plays an important role as a link between innate and adaptive immunity. IL-37 is a new player in inflammatory and immune responses, mediated by the IL-18/IL-18R axis. It was shown to inhibit tumor growth.
Source : E. coli
Species : Human
Tag : His
Form : Lyophilized from 0.2μm-filtered solution in 55mM TRIS-Cl, pH 8.2, containing 150mM NaCl.
Molecular Mass : ~20kDa (SDS-PAGE)
Endotoxin : <0.1eu g purified protein (lal test; lonza).>
Purity : ≥95% (SDS-PAGE)
Stability : Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Storage : Short Term Storage: +4°C; Long Term Storage: -20°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.
Gene Name : IL37 interleukin 37 [ Homo sapiens ]
Official Symbol : IL37
Synonyms : IL37; interleukin 37; IL1F7, interleukin 1 family, member 7 (zeta); interleukin-37; FIL1; FIL1(ZETA); FIL1Z; IL 1F7; IL 1H4; IL 1RP1; interleukin 1; zeta; interleukin 1 homolog 4; interleukin 1 related protein; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonical product IL-1F7b); IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1;
Gene ID : 27178
mRNA Refseq : NM_014439
Protein Refseq : NP_055254
MIM : 605510
UniProt ID : Q9NZH6
Chromosome Location : 2q12-q14.1
Function : cytokine activity; interleukin-1 receptor antagonist activity; interleukin-1 receptor binding; interleukin-1 receptor binding;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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Can IL37 be used in children? 12/22/2022

The safety and efficacy of recombinant IL37 in children have not been established and need to be validated in further studies.

What is the action mechanism of IL37? 03/01/2022

The IL37 works by inhibiting the release of inflammatory mediators and regulating immune cell levels, thereby reducing the inflammatory response.

How long is the course of IL37? 10/13/2021

The length of treatment for IL37 varies depending on the severity of the disease and the patient's response, and generally requires long-term treatment.

Can IL37 be used to prevent inflammatory diseases? 08/04/2020

At present, there is not enough evidence to show that IL37 can be used to prevent inflammatory diseases, and further studies are needed to verify it.

Is IL37 suitable for the treatment of allergic diseases? 07/04/2019

IL37 has anti-inflammatory and immunomodulatory effects, and may have a certain effect on allergic diseases, but further studies are needed to verify it.

Can IL37 be taken orally? 05/30/2019

IL37 is currently mainly administered by injection, and oral administration studies are still under way.

Customer Reviews (3)

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Reviews
01/16/2021

    IL37 has a long half-life and is able to maintain stability and reliability during experiments.

    02/28/2020

      When using IL37 protein for experiments, it can meet specific experimental requirements and research purposes.

      03/15/2019

        IL37 products have a complete range of specifications and are suitable for experimental designs of different sizes and needs.

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