IL9

  • Official Full Name

    interleukin 9

  • Background

    The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
  • Synonyms

    IL9; interleukin 9; P40; HP40; IL-9; interleukin-9; cytokine P40; p40 cytokine; TTHUMP00000159423; T-cell growth factor p40; p40 T-cell and mast cell growth factor; homolog of mouse T cell and mast cell growth factor 40;
    • Type:
    • Recombinant Proteins
    • Transfected Stable Cell Lines
    • Antibody
    • Cell & Tissue Lysates
    • GMP Proteins
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus monkey
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Hordeum Vulgare
    • Human Cells
    • Insect Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Alexa Fluor 647
    • Biotin
    • DYKDDDDK
    • Fc
    • GST
    • His
    • His (Fc)
    • Avi
    • His(N
    • ter)
    • His|T7
    • HQ
    • N/A
    • N
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken IL9-3294C Recombinant Chicken IL9 Mammalian Cell His
    Human IL9-28162TH Recombinant Human IL9, His-tagged His
    Human IL9-115H Human Interleukin-9 (rDNA derived) Reference standard N/A
    Human DMABT-H19268 Mouse Anti-IL9 Monoclonal Antibody Mouse Biotin
    Human IL9-618HCL Recombinant Human IL9 cell lysate Insect Cell N/A
    Human IL9-003H Active Recombinant Human IL9, MIgG2a Fc-tagged CHO Fc
    Human DMABT-H19269 Mouse Anti-IL9 Monoclonal Antibody Mouse Alexa Fluor 647
    Human DMABT-H19270 Mouse Anti-IL9 Monoclonal Antibody Mouse Biotin
    Human IL9-14214H Recombinant Human IL9, GST-tagged E.coli GST
    Human IL9-8866H Active Recombinant Human IL9,His-tagged Hordeum Vulgare N/A
    Human Il9-001H Active Recombinant Human Il9, HIgG1 Fc-tagged, mutant CHO Fc
    Human Il9-002H Active Recombinant Human Il9, HIgG1 Fc-tagged CHO Fc
    Human IL9-4324HG GMP Recombinant Human IL9 protein E.coli N/A
    Human IL9-67H Recombinant Human IL9 protein E.coli N/A
    Human IL9-374H Recombinant Human IL9, His tagged Insect Cell His
    Human IL9-476H Active Recombinant Human Interleukin 9 E.coli N/A
    Human IL9-5342H Recombinant Human Interleukin 9, HQ-tagged Hordeum Vulgare HQ
    Human IL9-216H Recombinant Human Interleukin 9 Sf21 Insect Cell N/A
    Human IL9-668H Recombinant Human IL9 protein, His & T7-tagged E.coli His/T7
    Human IL9-5165H Recombinant Human IL9 Protein, GST-tagged Wheat Germ GST
    Human IL9-2327H Recombinant Human IL9 Protein, His-tagged E.coli N-His
    Human IL9-151H Recombinant Human IL9 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human IL9-192H Recombinant Human IL9 Protein E.coli
    Human IL9-230I Recombinant Human IL9 Protein CHO
    Human IL9-218H Recombinant Active Human IL9 Protein, His-tagged(N-ter) E.coli His(N-ter)
    Human IL9-0312H Recombinant Human IL9 protein, His-tagged HEK293 His
    Mouse Il9-2175M Recombinant Mouse Il9 Protein E.coli N/A
    Mouse IL9-858M Recombinant Mouse IL9 Protein (Met1-Pro144), His-tagged Insect Cell His
    Mouse Il9-1059M Recombinant Mouse Il9 Protein, His-tagged HEK293F N-His
    Mouse IL9-8181M Recombinant Mouse IL9 Protein Mammalian Cell His
    Mouse Il9-119M Recombinant Mouse Il9 Protein E.coli
    Mouse Il9-219M Recombinant Active Mouse IL9 Protein, His-tagged(N-ter) E.coli His(N-ter)
    Mouse Il9-01M Active Recombinant Mouse Il9 Protein, His-Tagged E.coli His
    Mouse IL9-4521M Recombinant Mouse IL9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il9-225M Recombinant Mouse Interleukin 9 Sf21 Insect Cell N/A
    Mouse IL9-4521M-B Recombinant Mouse IL9 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Il9-002M Active Recombinant Mouse Il9, MIgG2a Fc-tagged CHO Fc
    Mouse Il9-001M Active Recombinant Mouse Il9, MIgG2a Fc-tagged, mutant CHO Fc
    Mouse Il9-78M Recombinant Mouse Il9 protein E.coli N/A
    Mouse Il9-477M Active Recombinant Mouse Interleukin 9 E.coli N/A
    Rat Il9-6385R Recombinant Rat Il9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat Il9-676R Active Recombinant Rat Il9 Mammalian cells N/A
    Rat Il9-2171R Recombinant Rat Il9 protein E.coli N/A
    Rat Il9-6385R-B Recombinant Rat Il9 Protein Pre-coupled Magnetic Beads HEK293
    Rat Il9-1117R Active Recombinant Rat Il9 Protein, His-tagged Insect Cell His
    Rat Il9-1060R Recombinant Rat Il9 Protein, His-tagged HEK293F N-His
    Rat Il9-1685R Recombinant Rat Il9 Protein, His-tagged E.coli N-His
    Rhesus monkey IL9-2328R Recombinant Rhesus monkey IL9 Protein, His-tagged E.coli N-His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • IL9 Related Articles
    • IL9 Related Gene Family
    • IL9 Related Research Area

    IL9 involved in several pathways and played different roles in them. We selected most pathways IL9 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionVEGFAB;CSF1R;CXCL8;AMH;CCL14;IL19;TNFSF12;TNFRSF25;TNFSF18
    Jak-STAT signaling pathwayOSMR;BCL2L1;Il23a; Il12b;Il4ra;IL12RB2;PRL2;JAK2A;STAT1;IL12B
    AsthmaIL10;HLA-DMB;HLA-DQA2;IL5;IL3;RNASE3;HLA-DRB3;HLA-DOB;FCER1G

    IL9 has several biochemical functions, for example, cytokine activity, growth factor activity, interleukin-9 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL9 itself. We selected most functions IL9 had, and list some proteins which have the same functions with IL9. You can find most of the proteins on our site.

    Function Related Protein
    cytokine activityFASLG;INHA;IL12BA;OSTN;Kitl;Il1f8;INHBAB;IL22;IL31
    growth factor activityTGFB3;NTF7;CDNF;FGF20A;FGF2;CLCF1;IGF2A;GFER;INHBA
    interleukin-9 receptor binding

    IL9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL9 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL9.

    Venetz, D; Hess, C; et al. Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2000-2005(2015).
    Hoelzinger, DB; Dominguez, AL; et al. Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges. CANCER RESEARCH 74:6845-6855(2014).
    IL
    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    How is the clinical trial of IL9 progressing? 09/05/2022

    Several clinical trials are currently underway to evaluate the safety and effectiveness of IL9 in treating conditions such as asthma and allergies. However, the research is still in its early stages and more data are needed.

    How to obtain IL9? 03/13/2022

    IL9 can be synthesized in the laboratory by biotechnological methods. Before clinical use, it needs to go through strict quality control and testing.

    What is the action mechanism of IL9? 09/22/2021

    By binding to specific receptors, IL9 can activate relevant signaling pathways and regulate the development and function of immune cells. It can affect the activity of a variety of immune cells, such as T cells and macrophages.

    Howthe relationship between IL9 and other related cytokines? 05/02/2020

    IL9 has cross-action with other cytokines, which can regulate the expression and function of each other. For example, IL9 can promote the production of IL4 and IL13, and IL4 and IL13 can also promote the secretion of IL9.

    What are the clinical applications of IL9? 09/26/2019

    IL9 can be used to treat certain inflammatory diseases, such as asthma and skin allergies. It can regulate the response of the immune system and reduce the symptoms of related diseases.

    What is the mechanism of action of IL9 in the treatment of asthma? 01/11/2019

    The mechanism of action of IL9 in asthma treatment is not fully understood, but studies have shown that it can reduce the infiltration of inflammatory cells and the release of inflammatory mediators, thereby reducing the symptoms of asthma.

    Customer Reviews (3)

    Write a review
    Reviews
    08/04/2022

      Widely used, IL-9 is related to the occurrence of many diseases, such as asthma, esophageal cancer, colon cancer, fatty liver, etc., and has a wide range of research and application prospects. -

      04/14/2019

        In tumor therapy, IL-9 has immunoenhancement and anti-tumor effects, which can induce tumor cell apoptosis, inhibit tumor cell proliferation, and promote the killing effect of immune cells. -

        02/28/2019

          Because IL-9 is associated with many immune cells, its therapeutic properties exhibit lower toxic side effects compared to other immunotherapy approaches. -

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