IL9
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Official Full Name
interleukin 9 -
Overview
The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. -
Synonyms
IL9;interleukin 9;P40;HP40;IL-9;interleukin-9;cytokine P40;p40 cytokine;TTHUMP00000159423;T-cell growth factor p40;p40 T-cell and mast cell growth factor;homolog of mouse T cell and mast cell growth factor 40
Recombinant Proteins
- Human
- Mouse
- Rat
- Cynomolgus
- Chicken
- Rhesus macaque
- E.coli
- Insect Cells
- CHO
- Mammalian Cells
- Hordeum Vulgare
- C-His
- HEK293
- Sf21 Cells
- Mouse
- Human Cells
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Fc
- Non
- HQ
- T7
- Alexa Fluor
- Flag
- SUMO
- Avi
Involved Pathway
IL9 involved in several pathways and played different roles in them. We selected most pathways IL9 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway,Asthma, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asthma | IL13,FCER1A,HLA-DQA1,IL4,HLA-DMA,H2-AB1,HLA-DRB1,CD40LG,IL3,HLA-DRA |
| Jak-STAT signaling pathway | PRLRA,IL10RA,CCND3,IL21,GRB2,AOX3,CISHB,IL11RA2,IL3,SOCS2 |
| Cytokine-cytokine receptor interaction | CD70,BMPR1AB,EGFRA,IL2RGB,IL29,IL12B,TNFRSF19,TGFB1A,KITLG,CRFB16 |
Protein Function
IL9 has several biochemical functions, for example, cytokine activity,growth factor activity,interleukin-9 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL9 itself. We selected most functions IL9 had, and list some proteins which have the same functions with IL9. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine activity | IL17B,IL17C,BMP4,CMTM1,TGFB3,IFNA4,CMTM5,SCGB3A1,C1QTNF4,IFNL3 |
| growth factor activity | CTGF,VEGFAA,CSF1A,PDGFAA,AMBN,GDF10,FGF12A,LIF,TGFB1A,CSF1 |
Interacting Protein
IL9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL9 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL9.
Resources
Research Area
Common gamma Chain Receptor Family LigandsTh2 Cells
Th9 Cells
Common gamma Chain Family Ligands
Related Services
Related Products
References
- Venetz, D; Hess, C; et al. Glycosylation profiles determine extravasation and disease-targeting properties of armed antibodies. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2000-2005(2015).
- Hoelzinger, DB; Dominguez, AL; et al. Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges. CANCER RESEARCH 74:6845-6855(2014).
