Active Recombinant Human IL9 Protein

• Cat.No.: IL9-230I
• Product Overview: Recombinant Human IL9 Protein without tag was expressed in CHO.

Specification

• Description: Interleukin 9, also known as IL9, is a cytokine (cell signalling molecule) belonging to the group of interleukins. The protein encoded by this gene is a cytokine produced by T-cells and specifically by CD4+ helper cells that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin-9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness.
• Source: CHO
• Species: Human
• Form: Sterile Filtered White lyophilized (freeze-dried) powder.
• Bio-activity: ED50 < 1 ng/mL, measured in a cell proliferation assay using MO7e cells, corresponding to a specific activity of > 1 × 10^6 units/mg.
• Molecular Mass: 25-40 kDa, observed by non-reducing SDS-PAGE.
• AA Sequence: QGCPTLAGILDINFLINKMQEDPAS KCHCSANVTSCLCLGIPSDNCTRPC FSERLSQMTNTTMQTRYPLIFSRVK KSVEVLKNNKCPYFSCEQPCNQTTA GNALTFLKSLLEIFQKEKMRGMRGK I
• Endotoxin: < 0.2 EU/μg, determined by LAL method.
• Purity: > 95% as analyzed by SDS-PAGE and HPLC.
• Storage: Lyophilized recombinant human Interlerkin 9 (IL-9) remains stable up to 6 months at -80 centigrade from date of receipt. Upon reconstitution, rhIL-9 should be stable up to 1 week at 4 centigrade or up to 2 months at -20 centigrade.
• Storage Buffer: Lyophilized after extensive dialysis against PBS.
• Reconstitution: Reconstituted in ddH2O or PBS at 100 μg/mL.

Gene Information

• Gene Name: IL9 interleukin 9 [ Homo sapiens ]
• Official Symbol: IL9
• Synonyms: IL9; interleukin 9; interleukin-9; homolog of mouse T cell and mast cell growth factor 40; HP40; IL 9; P40; p40 cytokine; p40 T cell and mast cell growth factor; T cell growth factor p40; cytokine P40; T-cell growth factor p40; p40 T-cell and mast cell growth factor; IL-9
• Gene ID: 3578
• mRNA Refseq: NM_000590
• Protein Refseq: NP_000581
• MIM: 146931
• UniProt ID: P15248

Reviews

08/04/2022

The anti-interference ability of IL9 was excellent in Western blot, which avoided the interference problem in the experiment.

04/14/2019

This protein has high catalytic efficiency, high safety and high expression level, and is a precious resource in the field of scientific research.

02/28/2019

The reproducibility of IL9 is very good, which can reduce the error in the experiment and improve the repeatability of the experiment.

Q&As

How is the clinical trial of IL9 progressing?

Several clinical trials are currently underway to evaluate the safety and effectiveness of IL9 in treating conditions such as asthma and allergies. However, the research is still in its early stages and more data are needed.

How to obtain IL9?

IL9 can be synthesized in the laboratory by biotechnological methods. Before clinical use, it needs to go through strict quality control and testing.

What is the action mechanism of IL9?

By binding to specific receptors, IL9 can activate relevant signaling pathways and regulate the development and function of immune cells. It can affect the activity of a variety of immune cells, such as T cells and macrophages.

Howthe relationship between IL9 and other related cytokines?

IL9 has cross-action with other cytokines, which can regulate the expression and function of each other. For example, IL9 can promote the production of IL4 and IL13, and IL4 and IL13 can also promote the secretion of IL9.

What are the clinical applications of IL9?

IL9 can be used to treat certain inflammatory diseases, such as asthma and skin allergies. It can regulate the response of the immune system and reduce the symptoms of related diseases.

What is the mechanism of action of IL9 in the treatment of asthma?

The mechanism of action of IL9 in asthma treatment is not fully understood, but studies have shown that it can reduce the infiltration of inflammatory cells and the release of inflammatory mediators, thereby reducing the symptoms of asthma.